/ Hiring

Postdoctoral Research Fellow, Late Stage Pharmaceutical Development

Who We Are

At the Roche Group, about 80,000 people across 150 countries are pushing back the frontiers of healthcare. Working together, we've become one of the world's leading research-focused healthcare groups. A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 30 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. The headquarters for Roche pharmaceutical operations in the United States, Genentech has multiple therapies on the market for cancer and other serious illnesses. Please take this opportunity to learn about Genentech, where we believe that our employees are our most important asset and are dedicated to remaining a great place to work.

The Position

A post-doctoral research fellow position isavailable in the Late Stage Pharmaceutical Development group to investigate thetemperature and concentration dependence of protein interactions in solutionand cryogenic conditions. Many monoclonal antibody (MAb) products are developedas high concentration solutions, and have been observed to present a range ofissues (aggregation, precipitation, phase separation) on storage. Thetemperature dependence of intermolecular interactions between proteins andother solution components remains poorly understood, in particular in cyro-concentratedconditions. The objective of the post-doctoral research fellow will be to characterizethe temperature dependent interactions of antibodies in both liquid and frozen glassystates, using a variety of biophysical techniques and novel experimentalapproaches to gain understanding of the underlying molecular basis of theprotein and solvent interactions that result in a variety of bulk solutionbehaviors.

Who You Are

A Ph.D. in biophysics, biochemistry, biomaterials, materials science, chemical engineering, or a related discipline is required. The candidate must have a strongscientific background and excellent analytical / problem solving skills. Experiencein more than one of the following subjects is highly desirable: general proteinlaboratory methods, static light scattering, small angle x-ray scattering, solutionthermodynamic theory, and mathematical modeling/ simulation software (i.e. MATLab,PyMol). The candidate will be responsible for devising and carryingout experimental strategies, presenting data at internal forums and externalmeetings when appropriate.  The successfulapplicant must be self-motivated, have excellentorganization, communication and collaborative skills, and be able to work bothindependently and as a member of a team.

** 2 yr position with an option for a 3rd yr  **

*LI-KO1

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Genentech is an Equal Opportunity Employer.