/ Hiring

Scientist - Small Molecule Discovery Toxicology

Who We Are

At the Roche Group, about 80,000 people across 150 countries are pushing back the frontiers of healthcare. Working together, we've become one of the world's leading research-focused healthcare groups. A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 30 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. The headquarters for Roche pharmaceutical operations in the United States, Genentech has multiple therapies on the market for cancer and other serious illnesses. Please take this opportunity to learn about Genentech, where we believe that our employees are our most important asset and are dedicated to remaining a great place to work.

The Position

The Department of Safety Assessment at Genentech providesscientific leadership and plays an active role in the process of drugdevelopment from late-stage discovery through marketed products. We are seeking an Associate Scientist/Scientist in the Department of Safety Assessment to supportdrug discovery and development.   This role will involve working in acollaborative team environment as part of the comprehensive safety assessmentof Genentech therapeutics by providing discovery and investigative toxicologysupport to early stage small molecule research programs.  

Responsibilities

Proactive risk assessment ofpotential toxicity issues related to undesired or exaggerated pharmacology,investigation or characterization of potential toxicity issues to enable smallmolecule lead optimization and candidate nomination.

 

In this role, the toxicologist willprovide representation to discovery project teams, which will include safetytarget assessments, strategic planning and designing, implementing andsupervising  toxicology studies in support of compound lead optimization(e.g. in vitro toxicity screening, counter-assay development) and mechanisticinvestigations (development of hypothesis-driven research plans, in vitro or invivo model development and qualification, and scientific projectmanagement).  This position will include staff supervision as needed andcontributing to the continued refinement of lead optimization andinvestigational strategies and identification of new technologies.  Thediscovery toxicologist will interact closely with research scientists andSafety Assessment development toxicologists and pathologists to ensure thatdiscovery teams consider all of the appropriate strategic needs for candidateidentification with regard to toxicology issues, thus providing bettercandidate selection and characterization of toxicology issues at the time oftransition to early development.

Who You Are

A PhD and post-doctorate orequivalent experience in immunology, neurobiology, infectious disease,cellular/ molecular biology, toxicology or related field is required.  2-4 years relevant experience in the pharmaceutical/biotechnology/CROindustry related to toxicology.  The candidate should also have a strongscientific aptitude and problem-solving skills; relevant experience in leadoptimization strategies and investigation of safety issues and havedemonstrated significant accomplishments in the area of relevanthypothesis-driven work and impact; strong communication, interpersonal andmanagerial skills; team-based drug discovery/development experience

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The next step is yours. To apply today, click on the "Apply online" button below.

Genentech is an Equal Opportunity Employer.