Position Purpose:

To provide high quality management, coaching and functional expertise to individuals so that they maximally contribute, deliver and develop.

 

To contribute to Study Management function to develop as a Centre of Excellence for either insourced or outsourced studies and ensure effective implementation at the Site.

Major Responsibilities and Accountabilities:

 

1.     People Development and Management

 

·       Manage, coach and develop people in order to maximize their capability and contribution to provide high quality deliverables.

·       Create a positive work environment by encouraging mutual respect, innovation and accountability at all levels (local, global, functional, projects/programs).

·       Ensure that employees are appropriately trained, developed and coached to comply with Company and regulatory standards.

·       Ensure that communication is managed consistently in a timely manner with the appropriate context.

·       Support management and staff in a matrix environment.

·       Conduct ongoing performance management dialogue. Complete the required steps of the performance management cycle.

·       Conduct individual development plans/career discussions.

·       Actively contribute to the performance calibration, talent management and succession planning process.

 

2. Functional Expertise and Oversight

·       Maintain an oversight of execution of work and deliverables.

·        Ensure that standards and processes are implemented locally to create consistency, efficiency and high standards of compliance.

·        Work effectively with the relevant local and global management to ensure that sufficient, appropriately qualified resources are identified, made available and allocated.

·        Lead/contribute to regular functional forums (at all levels) to ensure knowledge sharing and consistency.

·        Advocate/drive changes within the organization and lead by example.

·        Ensure adherence to company and departmental policies, procedures, guidelines and training compliance (including time reporting, travel approvals, expense reports, conference attendance, etc.)

·       Escalate issues when needed and encourage resolution at the lowest appropriate level.

·       Contribute to the development of global standards, processes and functional initiatives.

·       Proactively manage key stakeholders.

...

The Position

We have an opening for a bioinformatics scientist to support development, regulatory, and discovery needs for infectious disease therapeutics. These include deep sequencing of viral and bacterial pathogen DNA from clinical trials to discover and analyze resistance mutations, analysis of host-pathogen interactions in clinical samples and preclinical models, and genomic analysis of both individual bacterial species and bacterial communities. Contribution to regulatory filings will be expected. Close interactions with bioinformatics and infectious disease scientists will be required to achieve these goals. The successful candidate will become an important member of teams developing breakthrough and life-saving therapies. High levels of drive, innovation, attention to detail, independence, and accountability will be required for success, along with flexibility to work with diverse teams that encompass all aspect of drug development. There will be opportunity and expectation to develop new computational methods, discover fundamental new understand and actively publish research results.
...

Genentech seeks a talented and highly motivated Computational Biologist to pursue research projects in collaboration with our Department of Oncology Biomarker Development. The primary focus is translation of complex biomarker data into useful diagnostic tools that can guide our understanding of drug activity in patient tumors and identify subsets of patients who may benefit from specific therapeutic interventions.

A successful candidate will work with interdisciplinary teams (including biomarker, clinical, biostatistics and bioinformatics scientists), will carry out data analysis and integration across various domains, and will develop novel methods for identifying diagnostic and prognostic biomarkers. Regular publication of scientific and methodological results is strongly encouraged. Finally, the successful candidate must be able to effectively present complex results in a clear and concise manner — to other bioinformaticians as well as to audiences without a computational or statistical background.
...

Requirements:

• Provide statistical expertise to multiple nonclinical areas, including projects in research, preclinical studies, assay development, bioprocess development, quality control, and manufacturing.
• Propose experimental design and analysis strategies, perform statistical analyses, and collaborate with investigators to ensure the statistical integrity of nonclinical reports.
• Support regulatory submissions and investigations.
• Build strategic partnerships with collaborators and promote statistical thinking in decision making in nonclinical areas of drug development.
• Provide advice and training on the use of statistical methods and software packages to nonclinical investigators within the company.
• Develop and deliver statistics courses to nonclinical audiences
  Collaborate with scientists in support of external publications.
• Keep abreast of new developments in statistics, drug development, and regulatory guidance through literature review, conference attendance, and professional activities.

...

Job Description (gRED ECD Onc Clinical Science Specialist [E4a])

Genentech is seeking a Clinical Science Specialist (CSS) with clinical and drug development experience in oncology to join the Genentech Research and Early Clinical Development (gRED) Oncology ECD organization and support Clinical Science deliverables for clinical trials and programs associated with the exploratory clinical development of novel anti-cancer agents within the Genentech portfolio. These programs span first-in-human Phase I studies through proof-of-concept Phase II studies in a variety of malignant disorders, and may involve collaborations with other Clinical Development teams at Genentech, corporate development partners, and external scientific/academic/clinical organizations. The optimal candidate will have the desire to proactively participate within a multi-disciplinary team of internal clinical and commercial colleagues and have the ability to interact with external experts and investigators.

Job Duties and Responsibilities:

Scientific Writing

• Draft Strategic Context Documents (SCD), Clinical Protocols, and Investigator Brochures, and coordinate the successful completion of documents with medical editing.
• Conduct literature searches, draft abstracts, draft safety narratives, draft background sections of clinical documents, and ensure that standardized disease/molecule protocol language is incorporated (e.g., eligibility, dose-modification criteria, risk language, key scientific statements). Track items for inclusion in protocols and ICF amendments and work with Medical Editing to ensure the completion of the protocol and any subsequent amendments.

Functional Activities

• Serve as a Clinical Science representative on cross-functional teams as assigned (i.e., Protocol Execution Team, Safety Sub-Team, Biomarker Sub-Team, cross-functional initiatives).
• Identify and implement processes to share clinical information across teams/molecules/indications.
• Develop study-specific listings with data management representatives and conduct frequent clinical data listing reviews.
• Working closely with the gRED medical monitor, serve as primary point of contact for, and triage, clinical study inquiries from site staff, CROs and site monitors regarding the study protocol, modifications to informed consent, and patient-specific questions. .
• Partner with Data Management for CRF design, instructions for unique CRFs, and data quality plan.
• In conjunction with a Medical Director, create and or review clinical slides for internal and external meetings (i.e. Investigator meetings, PSSV and SIVs, Study Coordinator and CRA training, Advisory Boards, scientific meetings). Develop and QC data tables with biostatisticians to support these activities.
• Participate in tracking/analysis of any potential safety events within a given trial and across trials for assigned program(s).
• In conjunction with Biostats and Medical Director review appropriate analysis and reporting documents (i.e. clinical study report, analysis plan, etc.).
• As assigned, participate in development of the long-range strategic plans for the assigned program(s).
• As assigned, participate in Clinical Science assessment of in-licensing opportunities.
• As assigned, mentor and/or train new Clinical Science Specialists

...

The Department of Bioinformatics and Computational Biology in
Genentech Research is seeking a motivated individual to lead the
development of software methods and infrastructure for the analysis of
high-throughput biological data. This work will be in close
collaboration with other computational researchers, as well as the
broader community of Genentech scientists, who are together seeking
novel therapies for unmet medical needs. Much of the software will be
developed in R, as it is our primary data analysis
environment. Interesting challenges include the scale of the data and
the need for agility in a fast-paced, dynamic research
environment. Publishing of methods and software is encouraged, and
there is potential for collaboration with open-source projects. There
is also opportunity for investigating open scientific problems in
computational biology, such as variant calling, functional assessment
of non-coding transcripts, and the relationship between copy number
variation and expression....

Global Competitive Intelligence Manager/Sr Manager, Infectious Deceases

Based in South San Francisco or Basel

Global Competitive Intelligence Manager/Sr Manager - Key Activities:

¿ As a member of the Global Strategic Analytics Team, the successful candidate will be an important strategic business partner to the global marketing teams; International Business, Lifecycle, Disease Area Strategy teams and Roche Partnering.
¿ Works in close collaboration with the International Business Analyst, generating synergies within Strategic Analytics for GPS and the Roche organization
¿ Responsible for cross-functional collaboration to determine competitive landscape for both development and marketed products
¿ Defines and frames business challenges and decision requirements with key stakeholders based on a clear understanding of client needs and priorities. Works with key internal stakeholders and International Business Analyst (IBA) to develop, update and answer key intelligence topics and questions
¿ Leads the collection of competitor information and competitive intelligence from internal and external sources (both published and unpublished) and undertakes the synthesis, analysis and dissemination of this information to support strategic decision making.
¿ You will be responsible for conducting international Competitor Intelligence projects using a variety of methodologies.
¿ Monitors key competitors and ensures timely dissemination of critical intelligence and associated recommendations to appropriate stakeholders.
¿ Leads the coordination, planning and execution competitive coverage at conferences
¿ Proactively promote best CI practice within Roche
Creates an environment of strong team spirit, excellent communication, high motivation and inspires other team members to achieve goals in line with Roche strategies

...

Provides the operational expertise and leadership to one or more clinical operations teams to ensure the effective and efficient delivery of all operational aspects of one or more studies through all phases of Clinical Study Management (Plan, Initiate, Conduct, Close), in accordance with the appropriate quality standards including ICH/GCP and applicable regulations.

Main Responsibilities and Accountabilities:

• Provides direction and leadership to one or more clinical operations teams
• Develops operational plans including site monitoring strategies, risk mitigation strategies, trial budgets, site selection, and clinical supplies management.
• Builds effective and efficient high performing operations teams and ensures team members are aware of their accountabilities, responsibilities and deliverables.
• Creates team culture and promotes team spirit.
• Develops and maintains effective working relationships with SMT members, with particular focus on affiliate teams, external CRO (for outsourced teams) and co-development partner study teams.
• In collaboration with functional management, coaches, mentors, supports, and provides study specific direction to Study Management team members.
• Oversees the development and maintenance of study specific manuals created by the GSA.
• Contributes to the development and management of the study timelines, resources, budget, risk and quality plans
• Ensures operational tracking tools are identified, including systems to meet the needs of the operations team and ensures reporting to the GSL.
• Develops and manages clinical study budgets (including HQ budget) and contributes to staffing/resourcing plans.  Communicates variances in the budget and action plan for resolution to the GSL.
• Establishes study milestones and ensures accurate tracking and reporting of study metrics. 
• Provides operational input into the development of protocol feasibility questionnaires. 
• Provides clinical operations expertise to ensure operational feasibility and delivery
• Leads the development and finalization of site feasibility questionnaires.
• Leads the creation of the study level patient recruitment plan and retention strategies based on feasibility data and input from the affiliate teams and consultation with the GSL and OPL.
• Provides operational input and insight into all study related documentation (including protocol and informed consent form) and processes.
• Analyzes the feasibility data across countries with input from the affiliates and makes recommendations to the GSL for the strategic country and site distribution and patient numbers.
• Oversees forecasting of clinical/non-clinical supplies
• Designs drug assumption and supply chain process in partnership with Pharma Technical Drug Supplies, affiliates and GSL.
• Oversees the forecasting and management of non-clinical supplies to ensure sites have supplies to run clinical study.
• Delivers the operational elements of the study plan
• Chairs operations team meeting and organizes the investigator meetings, monitor training, CRO kick-off meetings.
• Ensures that reporting of SUSARs is established and maintained for the duration of the study.
• Proactively manages actual study level recruitment versus planned patient recruitment status and communicates variance to the GSL and implements contingencies in consultation with the GSL.
• Primary contact with affiliates to maintain oversight of performance, issues, and their resolution and identify systematic issues and coordinates any corrective action.
• Ensures the completion and finalization of any corrective and preventative action plans resulting from internal site audits.
• Oversees the maintenance of drug supplies and resolution of issues with input from the Pharma Technical Drug Supplies.
• Coordinates responses to study questions or issues from Health Authorities or IRBs/IECs.
• Provides operational input into the development and tracking of SMT goals.
• Provides the day-to-day operational management of CROs and vendors to ensure delivery against contracted scope of work
• Performs ongoing vendor management (e.g., CROs, Central Labs, IVRS, Reading Centers), including independent negotiation of scope of work, budgets, performance management, and issue resolution.
• Develops and executes appropriate site and CRO/vendor audit and quality plans.
• Identifies areas of best practice and process improvements
• Participates in Pharma Development Operations initiatives and programs as assigned.
• Maintains oversight and ensures consistency of the operational aspects across studies within a project.
• Ensures study adherence to ICH/GCP and SOPs
  

...

Group Market Planning Manager Global Product Strategy

Leads a team of 3 International Business Analysts (IBA) that participates actively in global commercial planning efforts by providing unbiased, objective, in-depth information about current and future markets, product performance, customers, and competitors. Additionally, he or she identifies critical business issues and opportunities for growth, collaborates with Roche/Genentech teams, and works to embed an external market point-of view into the strategic direction of the company. This individual will be both a manager and an individual contributor.
This role is a global role based in South San Francisco and he or she is required to travel nationally and internationally.

Key Accountabilities

• Provide an objective commercial viewpoint based on an in-depth understanding and analysis of commercial information.
• Lead team to proactively assess external marketplace/other related factors to support strategic decision-making
• Define/oversee various Strategic Analytics projects and other work completed by team
• Ensure provision of strategic insights/recommendations; enabling business¿partners/stakeholders to make the best-informed decisions regarding their strategies, plans, etc.
• Develop/manage operating budgets and other resource requirements
• Hire, develop and oversee the work of direct/indirect reports
• Comply with all laws, regulations and policies that govern the conduct of Roche/Genentech ¿activities
• Business travel, by air or car, is required for regular internal and external business meetings¿
Capabilities:
• Effectively manage a team of highly driven professionals. Motivate, develop, and retain top talent.
• Grasps key issues quickly, understands the "big picture" and links market research findings to larger issues.
• Uses rigorous logic and methods to solve difficult problems with effective solutions.
• Can see hidden problems; looks beyond the obvious and doesn't stop at the first answers.
• Uses creativity and ingenuity to develop solutions to complex problems, formulates strategies and approaches which may fall outside historical norms.
• Strong commitment to quality. Consistently and thoroughly reviews work for accuracy before sharing with a wider audience. Delivers final products that are well vetted and reliable.
• Demonstrates persuasive written and verbal communication skills. Is effective in a variety of presentation settings. Is comfortable around higher management.
• Can deal with ambiguity and act without having the total picture, is able to effectively pose questions in order to “tease out” information required for decision-making. Can handle risk and uncertainty
...

Market Planning Manager, Oncology - Global Product Strategy

Participate actively in global commercial planning efforts by providing objective, in-depth analyses on current and future markets, product performance, customers, and competitors. Additionally, identify critical business issues and opportunities for growth, collaborate with Genentech/Roche teams, and work to embed an external market point-of view into the strategic direction of the company.

This Global Market Planning Manager / International Business Analyst position is a global role based in South San Francisco. This individual will be a member of a global cross-functional team focusing on development of our pipeline products and will be required to travel domestically and internationally.

KEY ACCOUNTABILITIES:
*Proactively and continuously assess the relevant marketplace and its dynamics, customers and competitors to enable strategic decision making regarding brands and business operations.
*Business partner within assigned cross-functional teams: developing strategic insights and providing in-depth product and marketplace knowledge.
*Ensures alignment across internal partners, stakeholders, and senior management.
*Leads initiatives to facilitate growth and development of the Global Strategic Analytics team
*Responsible for new market and product opportunity assessments.
*Creates, manages, validates, and refines forecasts (product and market)
*Communicates revenue forecasts and assumptions to internal partners, stakeholders, and senior management.
*Develops and implements market research plans, in conjunction with cross-functional teams.
*Provides analytical input to the Disease Area Director during due diligence for in-license opportunities and liaises with partnering groups.
*Actively contributes to cross-functional or other project teams, helping the overall business evolve, improve & excel.
...

S3

Who we are

At the RocheGroup, about 80,000 people across 150 countries are pushing back the frontiersof healthcare. Working together, we've become one of the world's leadingresearch-focused healthcare groups. A member of the Roche Group, Genentech hasbeen at the forefront of the biotechnology industry for more than 30 years, usinghuman genetic information to develop novel medicines for serious andlife-threatening diseases. The headquarters for Roche pharmaceutical operationsin the United States, Genentech has multiple therapies on the market for cancerand other serious illnesses. Please take this opportunity to learn aboutGenentech, where we believe that our employees are our most important asset andare dedicated to remaining a great place to work.

 

The Position

The successful candidate will participate in cross-functionalproject teams discovering antibodies with high therapeutic potential to addressmajor unmet medical needs across different therapeutic areas.  This hire will lead a group discoveringantibodies from immunized sources. Research by this group will included enhancing understanding andoptimizing the immune response in immunized mice plus isolation and culturingof antigen-specific B cells.  Thisindividual is expected to collaborate closely with colleagues in other antibodydiscovery groups and other departments.

...

We are seeking a highly qualified and motivated individual to join the Small Molecule Pharmaceutics and Delivery group at Genentech. The candidate will be responsible for conducting pre-formulation and formulation evaluation of research molecules and clinical development compounds, such as solubility measurement, stability test, recrystallization, granulation evaluation, tablet development. He/she will also work on characterizing salts and polymorphs of small-molecule compounds; developing pre-clinical dosing formulations and supporting Discovery Biology, Efficacy, and Safety Evaluation of new chemical entities. The individual will be involved in formulation development in support of Clinical trials, such as excipient screening, prototype and market formulation development and technical transfer, and solid state stability monitoring.
...

The Department of Small MoleculePharmaceutics in Genentech Research and Early Development is seeking a highlymotivated Senior Scientific Manager to lead an effort in pharmaceuticalprofiling and development, during preclinical and early clinical assessment, ofnovel small molecule therapeutics for unmet medical needs. The successfulcandidate will head a small group of scientists, and is expected to:

• Provide exceptional scientific leadership within Small Molecule Pharmaceutics, as well as to other functions, subteams and teams at Genentech

• Develop and effectively manage a small laboratory group focusing on selection, profiling and advancing small molecule clinical candidates in a scientifically rigorous, phase-appropriate manner 

• Drive scientific and technical innovation collaboratively with other members of the Department

• Develop and execute preformulation and formulation strategies based on strong scientific rationale and pharmaceutical/biopharmaceutical properties of the molecule for one or more projects

• Author development reports and relevant CMC sections for regulatory filings

• Publish in high quality scientific and pharmaceutical journals

• Participate and thrive in an interactive, team oriented culture, interfacing with discovery and early development functions

...

Weare seeking one or more seasoned and dynamic thought leaders in oncologytranslational sciences / medicine to join the Oncology Biomarker Development(OBD) group at Genentech.

The AD/D of predictive diagnostics will provideexceptional scientific and strategic leadership for therapeutic franchises and/ or disease-based biomarker activities in support of a large number ofoncology molecules in late-stage clinical development and/or FDA-approved.

Leading a team of lab-enabled scientists / Sr. scientists, the incumbent willbe responsible for development and oversight of the Franchise biomarkerstrategies and ensuring successful execution of drug-diagnostic co-developmentin collaboration with the Companion Diagnostics Development group within OBD.

The successful candidate may also serve as a Biomarker Subteam leader for oneor more molecules within their Franchise area. This role requires an individualwith outstanding communication and leadership skills, as well as the ability tobuild strong relationships with key stakeholders in product development andother relevant functions and navigate challenging situations.

The individualmust also be viewed as a strong scientific and strategic leader, one who canreadily bridge between a cutting edge Research environment and a fast-pacedclinical and product development organization. The successful candidate isexpected to drive the publication of biomarker data in high quality scientific,technical or medical journals, to represent the department and programs at externalmeetings, to be a key representative to our investigators, and to promotecollaborative efforts to forward the biomarker sciences field in general. Thisis an important leadership role with substantial visibility within Genentech /Roche organization.

 

As an AD/D, you areexpected to:

• Provideexceptional scientific leadership across multiple molecule teams, to your peerswithin OBD and to the organization in general with a particular focus on latestage development
• Provideleadership, visibility and expertise to the oncology product developmentorganization on all biomarker related question for a specific therapeuticfranchise
• Leadbiomarker strategies at a franchise level, and lead one or more biomarkersubteams
• Representbiomarker related strategies and plans to late stage development review forums,decision committees and project teams.
• Leadbiomarker related regulatory strategies and interactions with healthauthorities around the globe including review of relevant regulatory documents
• Bean active member of the OBD Leadership Team, contributing to the continuingstrategic development of our Department and our people
• Leadand drive scientific and technical innovation collaboratively with othermembers of the Department
• Drivehigh quality publications in high impact scientific, technical or medicaljournals
• RepresentOBD externally through presentations at key National / International meetings,interactions with our key investigators
• Participateand thrive in an interactive, team oriented culture

...

We seek a highly motivated Scientist / Sr. Scientist to lead biomarker development efforts in support of Genentech’s Oncology pipeline. The incumbent will lead a small laboratory group focusing on predictive and pharmacodynamic biomarker development efforts, as well as lead and support biomarker subteams for programs in clinical development. All of the Scientists in OBD are encouraged to develop a focus in one of several areas that advance our understanding of specific diseases or enable advanced biomarker assessments through exploration of innovative, cutting-edge technologies.  For this particular position, a strong background in cancer cell signaling and cancer genomics, evidenced by peer reviewed publications in top tier journals, is required.  Practical experience with predictive or pharmacodynamic biomarker development in an industry setting would be an important asset.  The successful candidate is expected to effectively lead cross functional teams, to publish innovative biomarker or disease focused research in high quality scientific, technical or medical journals, present to our key investigators and at meetings and promote collaborative efforts to push biomarker sciences forward. Scientists / Sr. Scientists in OBD are expected to be, or develop into, externally recognized leaders in clinical translational sciences.

 

 

As a Scientist / Sr. Scientist, you are expected to:

• Provide exceptional scientific leadership within OBD, as well as to other functions, subteams / teams at Genentech / Roche
• Develop and effectively manage a small laboratory group, predominantly focused on scientific support for molecule programs
• Drive scientific and technical innovation collaboratively with other members of the Department
• Lead one or more biomarker subteams
• Develop and execute on lead and exploratory biomarker strategies for one or more projects
• Participate in, or lead, disease focused translational biomarker programs, or develop a key focus on novel technologies that advance clinical biomarker assessment
• Publish in high quality scientific, technical or medical journals
• Represent OBD externally through presentations at key National / International meetings, interactions with our key investigators
• Participate and thrive in an interactive, team oriented culture

...

We are seeking a highly motivated individuals to join the Oncology Biomarker Development Dept. to lead companion diagnostic (CDx) development programs in support of the Roche / Genentech early and late stage Oncology clinical development pipeline. The incumbent will provide leadership for a portfolio of molecules within a Franchise and represent these programs to senior management and decision-making bodies internally.

The CDx development strategies will be closely aligned with clinical development program timeline and strategy to enable robust clinical validation of the CDx, including establishment of thresholds and statistical analysis of the relationship with efficacy or safety using robust assays developed with diagnostic partners. The incumbent will also develop cross- functional relationships with internal scientific, operational and regulatory groups and diagnostic partners, and represent GNE / Roche CDx efforts to external professional organizations and regulatory bodies. The successful candidate will also be expected to contribute to Medical Affairs strategies to enable biomarker hypothesis testing.

 

Responsibilities

• Work closely with the biomarker, regulatory, statistics and clinical leadership to ensure development and effective operational execution of the CDx portfolio of multiple investigational agents in Franchises or Disease Area
• Management of direct and matrixed reports whose responsibilities will include programs in both early and late stage clinical development. A substantial focus will be in early development where design of CDx strategies that enable device development in preparation for hypothesis testing will be important. Therefore requires strong understanding and experience with development of diagnostic devices in order to develop fit for purpose CDx strategies.
• Develop and lead strategic initiatives to identify novel CDx technologies and develop relationships to enable effective evaluation of technologies as CDx assays.
• Develop and lead IVD strategies that are aligned with disease areas including development of multiplex platforms to support investigational and approved products in collaboration with diagnostic partners.
• Enable the coordination and execution of exploratory biomarker hypothesis testing in the clinic.
• Develop relationships with external key investigators, scientists and professional organisations in the diagnostic technology field to inform internal CDx strategies including next generation technology implementation and validation.
• Represent CDx strategy to health agencies as part of the regulatory strategies for the agents within the entire portfolio.

...

The Biomarker team in Early Development has an opening for a summer intern.

Responsibilities may include but are not limited to the following:

Evaluate and develop methods for capture and molecular characterization of circulating tumor cells (CTCs) . 

1- develop methods for identification of CTCs of epithelial and non-epithelial origin, and algorithms for automatic detection of CTCs.

2- evaluate diagnostic markers on CTCs using imaging methods (IF, ICC). 

3- develop methods to isolate single CTCs and evaluate downstream molecular analysis platforms.

...

The Discovery Oncology department is seeking an exceptional and highly motivated scientist to join a team focused on the discovery and validation of novel oncology drug targets and the discovery of biomarkers predictive of the clinical efficacy of novel cancer therapeutics. Current efforts of this team are largely directed to developing a mechanistic understanding of tumor cell sensitivity and resistance to molecularly-targeted anti-cancer agents. Aspects of cancer cell biology of particular interest include epigenetic regulation and intra-tumor heterogeneity.

...

The DMPK group is dedicated to enabling the discovery, developmentand commercialization of safe and effective medicines by elucidating theabsorption, distribution, metabolism, excretion and pharmacokinetic propertiesof small molecule drug candidates. We accomplish this through the applicationof state of the art technologies and sciences of bioanalysis, drug metabolism,drug transport and pharmacokinetics. The DMPK group works in close partnershipwith disciplines such as medicinal chemistry, pharmacology, toxicology,pharmaceutical sciences, clinical pharmacology and regulatory to optimizeleads, select clinical candidates, conduct preclinical development studies,support clinical evaluation and contribute to IND and NDA filings

We are seeking a highly motivated individual who will be involved in the design, execution, supervision, and interpretation of pharmacokinetic studies. These studies will enable the selection of small molecule drug development candidates and provide detailed assessment of their pharmacokinetic characteristics.

The individual will be involved in the following activities as part of their role:

• Representation of DMPK at interdisciplinary project teams
• Pharmacokinetic data analysis and modeling
• Set-up and validation of in vivo ADME/PK models

...

The DMPK group is dedicated to enabling the discovery,development and commercialization of safe and effective medicines by elucidatingthe absorption, distribution, metabolism, excretion and pharmacokineticproperties of small molecule drug candidates. We accomplish this through theapplication of state of the art technologies and sciences of bioanalysis, drugmetabolism, drug transport and pharmacokinetics. The DMPK group works in closepartnership with disciplines such as medicinal chemistry, pharmacology,toxicology, pharmaceutical sciences, clinical pharmacology and regulatory tooptimize leads, select clinical candidates, conduct preclinical developmentstudies, support clinical evaluation and contribute to IND and NDA filings.

We are seeking a Senior ResearchAssociate/Research Associate to support Small Molecule Drug Discovery in theDrug Metabolism and Pharmacokinetics (DMPK) department.  The qualified candidate will work closely withour established team performing metabolic stability assays using hepatocytesisolated from various species, protein binding experiments in plasma, tissues,and microsomes from various species, and hypothesis-based in vitro metabolismassays to address specific mechanistic questions in drug discovery.  This person will perform weekly, fullyautomated, high-throughput, and high-capacity in vitro experiments to supportsmall molecule projects.  This personwill develop analytical methods (LC and MS/MS) to separate and detect smallmolecules and also proficient in using and troubleshooting LC-MS/MS.

...