We are seeking an energetic and accomplished Research Associate/Senior Research Associate in Early Discovery Biochemistry within Genentech.  Our group conducts early drug discovery and new target validation from a biochemical/physical, structural, and computational perspective and collaborates with diverse discovery biology areas in Genentech. The candidate must have excellent skills with directed evolution techniques, such as phage display, yeast display, and/or mRNA display. Preference will be given to candidates who also have experience in computational biology and/or biophysics. Projects will span a wide range of areas, and the candidate must be flexible, creative, and able to master new techniques as needed.
...

Dept: Biological Assays, Method Management and Technology, PTQBP

Job Category: Quality
Location: SSF

Department: MMTech (Method Management and Technology)
Description: Senior Scientist Bioassay

Summary

The Biological Assay Function within Genentech’s Global Quality Organization is responsible for life-cycle management and innovation of post-BLA biological potency methods and specifications. We serve as the scientific and technical Center of Excellence for biological assays and analytical ELISAs within Commercial Quality for the Roche/Genentech Global Quality Network. We are looking for an experienced Senior Scientist to take on a leadership role and to play an integral part in the function.

 
Requirements

Candidates must have in-depth experience in the development of cell-based potency assays and immunoassays in an industrial setting. Understanding of mechanism-of-action of antibody-based protein therapeutics is essential. Broad experience with a variety of biological in-vitro systems is required. Familiarity with antibody effector function determination and enzymatic assays would be an asset. Prior experience in assay validation/ qualification and technology transfer are highly desirable, as is GMP experience and a strong sense for compliance. Familiarity with common applications analyzing the dose-response relationship will be very helpful (SoftMaxPro, XLFit, PLA etc). Working knowledge of statistical approaches will be helpful. Must be highly motivated and comfortable working independently in a fast-paced environment. Experience with regulatory submissions (IND/BLA) and Health Authority interactions will be advantageous. Management experience of direct reports is expected.

...

This position is responsible for providing leadership and direction to a purification process development group in Purification Development.  The candidate will lead a team of 12-18 staff comprised of several groups of scientists and engineers and be responsible for the management and leadership of multiple early stage and late stage development and technology projects.  A high degree of initiative is expected to assess new areas and directions critical for Pharma Technical Development and Genentech’s future success.  Strong management skills to lead, motivate, and develop staff in their group is a key requirement for this position.  The candidate is expected to provide leadership to their groups and throughout Purification Development and across Pharma Technical Development.

...

Job Purpose:

The Team Lead for CSV auditors in PDQA is responsible for recruitment, management and leadership of department audit staff.  Through their leadership and direction, they ensure consistent implementation of PDQA processes and procedures and execution of the audit strategy related to Computer System Validation

Primary Responsibilities and Accountabilities:

• Provide leadership and direction to the PDQA CSV audit team in the execution of the department strategy
• Recruit, manage, train and develop staff
• Motivates and manages team members through setting of individual goals, provides on-going feedback and performance evaluations
• Oversee staff expenditures
• Collaborate with other Team Leaders to resource and manage the audit program in line with PDQA Strategy 
• Manage resources according to department strategy
• Review staff deliverables (audit plans, audit reports, quality plans, etc)
• May participate on audits as necessary (staff evaluations)

• Contribute to the development and execution of PDQA goals and initiatives
• Participate in or lead departmental or cross-functional compliance projects and initiatives as assigned
• Assists and/or contributes to the development and/or revision of PDQA SOPs, guidelines and tools

• Supports Head of CSV Strategy and TL, Validation Analysts to establish and implement global CSV strategy, goals and objectives for team
• Participates on IT/CSV projects and task forces to provide quality management oversight

• Ensure consistent execution of PDQA strategy, processes and procedures
• Oversee execution of department strategy, processes and procedures
• Provide CSV compliance advice to staff 
• Ensure audits are conducted and reported in compliance with departments procedures
• Support regulatory authority inspections
• Escalate compliance issues/risks to PDQA Management
• Maintain knowledge of HR Corporate policies and procedures
• Maintain knowledge of current regulatory, GCP, GLP, CSV and/or PV regulations and guidelines and company policies, SOPs and procedure

...

A multi-talented Informatics specialist in San Francisco is needed for the Global Pharma Informatics Safety Risk Management team. In this role you will work closely with the Business System Owner, users, development and support teams, vendors and service providers to provide an excellent service for the Drug Safety Systems globally. 

A true multi-talented professional is required – willing to play multiple roles as required within a dynamic global team – to ensure optimal support, service and application delivery to our internal customers.  You will act in multiple capacities such as service manager, solution life cycle manager and business analyst. Activities you are likely to be doing in this role are (but not limited to):

• Ensure Support globally is seamless and following our Global Support Model  - your primary responsibility will be the users in the Americas (North, Latin and South America), however you and your team may need to deal with critical incidents not resolved by the team located in the EU.
• Work in close collaboration with other Delivery Service Managers to ensure global support and prioritization of incidents and assignments
• Work closely with business users, business system owner and informatics to keep all stakeholders abreast of any significant impact and changes to the systems.
• Ensure the validated state of our systems and ensure compliance with applicable SOPs and policies governing the systems and processes.
• Provide business process support by understanding existing business processes, and offering advice, implementation of changes or reconfiguration to meet business objectives.
• Provide technical support and trouble shooting for our Safety Risk Management applications.
• Work in collaboration with business to identify business solutions and requirements for new functionalities, and performing impact analysis on systems and processes, and potential ongoing projects
• Work with vendor/service providers to ensure compliance with SLAs and support in service improvement initiatives.
• Develop excellent relationships with all layers of business
• Participation in systems projects
• Openness to take on new tasks and challenges outside the formal role description corresponding to skills and capacity

...

This position may be filled at a Contract Manager  or Sr. Contract Manager level.
 
The Managed Care Contracts Group manages the contracting process from development of an account-centric contract strategy through execution of an agreement. The Contract Manager, Managed Care Contracts develops, drafts, analyzes, negotiates and gains the necessary approvals for the assigned managed care accounts and contracts.

• Works closely with partners in field Account Management across MCCO Channel and Payer Field teams as well as GNE Government Affairs, reviewing customer contract needs, requirements, etc. in alignment with GNE contracting strategies, business objectives, and other contract conditions
• Conducts various analyses and modeling of appropriate contract terms and reviews with key internal partners/stakeholders
• Obtains all appropriate and required internal reviews and approvals for contract terms and provisions
• As needed, supports field Account Management partners in negotiating contract terms and conditions
• Responds to various partner/stakeholder questions, inquiries, requests for clarification, etc. regarding contracts and terms/conditions or other items
• Ensures execution of approved and finalized customer contracts; including timely and accurate hand-off to other internal partners/stakeholders
• Monitors existing customer contracts using approved performance methodologies, tools, etc.; includes identifying and recommending opportunities for improvement
• Helps garner maximum return on investment and customer satisfaction from all contract responsibilities
• Ensures all contract data and information is appropriately entered into relevant systems/databases
• Complies with all laws, regulations and policies that govern the conduct of Genentech activities
•  Business travel, by air or car, is required for regular internal and external business meetings
  

...

E4/E5

The purpose of the role is to provide high quality evaluation and sourcing of oncology, hematology, and tumor immunology opportunities.  This individual will also lead confidential due diligence evaluations and pursue BD licensing and partnership opportunities.

Job Duties/Responsibilities:

Responsible for screening potential oncology collaboration opportunities.

Lead more detailed diligence on selected high priority deals as part of diligence teams.

Provide effective liaison with Early Clinical Development.

Serve as a member of the Oncology Portfolio Committee.

Proactively source appropriate opportunities for GNE consideration from academic, literature, trade publications, meetings, etc.

Education of other BD professionals, including reviews of technical literature.

As appropriate, pursue BD licensing and partnership opportunities.

...

Sr. Product Manager

 Senior Product Managers in Managed Care Marketing develop, implement and manage the managed care marketing strategy, plan and tactics. Managed Care Marketing directly supports Genentech’s business by ensuring managed care marketing strategies, plans and tactics enable business, financial and operational goals, targets and objectives to be met or exceeded across managed care segments within the U.S. Senior Product Managers act as a primary liaison to managed care account management and may also have matrix responsibilities to represent Managed Care Marketing for one or more products or franchises, as assigned.

•  Stays abreast of and continuously develops his/her knowledge regarding internal and external business developments and drivers. Includes in-depth knowledge of the current and evolving managed care landscape and its implications for Genentech -  formulary positioning, reimbursement, access and overall market share

• Responsible for educating internal partners and stakeholders regarding the managed care landscape in the U.S. and related territories and implications of such to current, medium- and longer-term managed care marketing strategies, plans and objectives

• Reviews and assesses cross-functional business strategies, plans and tactics; using to determine and recommend managed care marketing strategies, plans and activities that support optimal formulary  positioning, reimbursement, access and overall market share

• Contributes new creative, innovative opportunities; increasing adoption, pull-through and overall financial results

• Develops the Value-based Healthcare (VBH) strategy and tactics; including driving and shaping key customer partner initiatives in oncology

• Works closely with cross-functional teams to align therapeutic area and managed care marketing strategies, plans and tactics with pricing, reimbursement, contracting, distribution and other relevant business, financial and operational strategies, plans and objectives 

• Contributes expert managed care marketing insights and perspectives into long-range business plans and other relevant 3-year and 1-year strategies and tactical plans

• Conducts field visits with key customers to review Genentech’s breadth of offerings

• Develops key VBH resources for MCCO (Managed Care & Customer Operations) field, collecting customer insights, creating tactics for case managers and training MCCO on resources

• Where applicable, supports product launches. May participate in the development and implementation of managed care marketing launch plans. Includes contributing managed care marketing expertise to other aspects of the overall launch plan and helping ensure launch plan excellence

• Works with cross-functional groups to ensure a seamless and well-integrated message and overall positioning across multiple marketing platforms, e.g., online, direct-to-patient, etc.

• Provides strategic consultation to brands and MCCO groups regarding key brand market events

• Creates appropriate marketing budgets by working with peers, manager and/or other internal partners

• Ensures appropriate and timely implementation of approved managed care marketing plans and tactics under his/her responsibility

• Continuously monitors and measures effectiveness and results from managed care marketing strategies, plans and objectives. Regularly reviews forecasting and other business analyses and uses to make appropriate further recommendations to increase market access, address currently unmet needs, and generally help to improve the overall market strength for Genentech in assigned managed care segments

• Directly manages the implementation of all assigned managed care marketing plans and tactics to ensure timely and quality execution that will meet or exceed assigned targets, goals and objectives

• Works with others to identify, recommend, create and help implement new account management tools/resources that will enable the field to represent Genentech in accordance with the defined strategy and position
  Complies with all laws, regulations and policies that govern the conduct of GNE activities
  

...

Position Purpose:

To provide high quality management, coaching and functional expertise to individuals so that they maximally contribute, deliver and develop.

 

To contribute to Study Management function to develop as a Centre of Excellence for either insourced or outsourced studies and ensure effective implementation at the Site.

Major Responsibilities and Accountabilities:

 

1.     People Development and Management

 

·       Manage, coach and develop people in order to maximize their capability and contribution to provide high quality deliverables.

·       Create a positive work environment by encouraging mutual respect, innovation and accountability at all levels (local, global, functional, projects/programs).

·       Ensure that employees are appropriately trained, developed and coached to comply with Company and regulatory standards.

·       Ensure that communication is managed consistently in a timely manner with the appropriate context.

·       Support management and staff in a matrix environment.

·       Conduct ongoing performance management dialogue. Complete the required steps of the performance management cycle.

·       Conduct individual development plans/career discussions.

·       Actively contribute to the performance calibration, talent management and succession planning process.

 

2. Functional Expertise and Oversight

·       Maintain an oversight of execution of work and deliverables.

·        Ensure that standards and processes are implemented locally to create consistency, efficiency and high standards of compliance.

·        Work effectively with the relevant local and global management to ensure that sufficient, appropriately qualified resources are identified, made available and allocated.

·        Lead/contribute to regular functional forums (at all levels) to ensure knowledge sharing and consistency.

·        Advocate/drive changes within the organization and lead by example.

·        Ensure adherence to company and departmental policies, procedures, guidelines and training compliance (including time reporting, travel approvals, expense reports, conference attendance, etc.)

·       Escalate issues when needed and encourage resolution at the lowest appropriate level.

·       Contribute to the development of global standards, processes and functional initiatives.

·       Proactively manage key stakeholders.

...

Position Overview/Job Responsibilities

Genentech Government Affairs’ Public Policy and Reimbursement team is seeking a qualified policy manager/senior policy manager candidate to monitor and analyze numerous public payer activities and trends, including coverage, coding, and payment policies at the national level for both Medicare and Medicaid.

Specifically, the policy manager/senior policy manager will help recognize, assess, and communicate key policy issues that may impact Genentech and the biotechnology industry in both the short- and long-term to key internal and external stakeholders. He or she will focus on the impact of public sector trends and initiatives on Genentech with respect to patient access, reimbursement, and customer satisfaction. He or she will translate policy developments into meaningful guidance and strategic advice and will represent the Public Policy team at internal and external meetings. He or she also will be responsible for managing projects effectively and efficiently, and will be required to take initiative to identify key issues and help organize and assist the efforts of other team members as appropriate.

...

This IT Manager is responsible for managing the Portfolio processes for Research and Development IT and for providing Project Management on a variety of projects that are used by Research and Early Development.  The position also oversees Portfolio/Project Management, Budgeting, Forecasting and related processes for Research and Development IT.  The position is part of the gRED IT organization.

Responsibilities: 

• Acts as Project Manager on projects, as assigned.
• Ensures that formal project management processes (PMM) are adhered to 
• for planning, chartering, and management of strategic initiatives and 
• projects. 
• Establishes and manages project teams and core teams to develop and 
• execute project plans. 
• Monitors projects and their progress towards goals, provides status, and 
• ensures issue resolution. Manages project budget and timeline to ensure 
• that they are efficiently delivered.
• Identify and implement process improvements in solution delivery and 
• support of new and existing solutions
• Collaborates with Pharma Informatics technology groups and business 
• functional groups, to ensure project delivery and on-going support of 
• applications.
• As the Portfolio Manager for gRED IT, partners and coordinates with Finance, gRED IT project managers and functional managers, other Portfolio Managers and the business to ensure appropriate project methodologies, governance and control processes are followed.  Also coordinates annual budgeting and monthly forecast/actuals processes and acts as the gRED IT representative on larger Pharma IT portfolio process improvement efforts.  Provides support and guidance to gRED IT project managers, as needed.
• Coordinates the yearly and project budget processes, including monthly forecasting, actuals analysis and resource management processes for your area of responsibility. 
• Provides support to the Director of gRED IT, as needed, related to creating general presentations, leading certain recurring meetings, etc.
• Participates in the Leadership Team of gRED IT organization

...

Job Summary:

Working in early clinical development at Genentech /Roche Inc gives the opportunity to provide translational safety contribution to projects combining good understanding and knowledge of toxicology and expertise in clinical safety and early clinical development, a very innovative approach where Genentech/Roche is a pioneer. 

Job Purpose: The Safety Science Leader (SSL) is accountable for all aspects of safety related to products in early development phase including single case assessment, aggregate reporting, integrated signal prediction/detection (ISP/ISD), integrated risk management process (ISMP) & comparative benefit/risk (in collaboration with Clinical and Regulatory) throughout the life cycle. The Safety Science Leader leads product specific safety analyses including medical evaluation, risk management, signal detection using epidemiology and other input as appropriate to ensure that adequate safety measures are implemented based on data. ¿The Safety Science Leader maintains an Integrated Safety Management Plan (ISMP) throughout the life cycle of the product or medicine and is accountable for safety components of various documents including study protocol, study reports, development study reports. The Safety Science Leader represents Safety Science in Research and Early Development teams (RED teams) . She/ He supports and facilitates transition of projects from early to confirmatory development for all aspects pertinent to safety. 

 

Primary Responsibilities and Accountabilities:

·      Contributes to scientific publications (abstracts, posters, papers) for scientific meetings/journals and approves submissions from a safety perspective. 

·      Reviews all communications to the public from a safety point of view. 

·      Keeps the EU QPPV fully informed of any changes to the benefit-risk relationship and, where appropriate, performs tasks as delegated by the EU QPPV. 

·      With the CSL and the DST, plans and performs, on an ongoing basis, an evaluation of the safety data to detect safety signals. On an ongoing basis with the team, evaluates the Benefit/risk relationship of the program and determines how to manage patients within and across trials.

·      Is accountable for safety components of all NDA documents. 

·      Is responsible for the writing and maintenance of RMP/REMS NDA documents. 

·      Represents Roche in interactions with Health Authorities and Independent Data Safety Monitoring Boards (ie Pre-BLA/NDA meetings, advisory committees) for safety related topics.  

·      Contributes to and where specifically delegated may be responsible for the proper execution of the post-approval RMP/REMS 

·      Ensures that all safety processes are properly supported and compliance is documented for all studies conducted by PD or PB or affiliates.

 People Leadership: 

·      Provides provide leadership and line management to the Safety Sciences department across multiple locations, aligning with other parts of the organization, where necessary. 

·      Ensures that the performance of direct reports is proactively managed and that they are coached, trained and developed to maximize their contributions.  

·      Allocates resources and is accountable for the assignment of his/her collaborators / reports according to their individual capabilities and in line with projects priorities.

·      Ensures that staff communication and employee relations are managed proactively to maximize the well being of employees. 

·      Actively installs the Roche values in the Safety Team and their activities.

...

The Department of Bioinformatics and Computational Biology in
Genentech Research is seeking a motivated individual to lead the
development of software methods and infrastructure for the analysis of
high-throughput biological data. This work will be in close
collaboration with other computational researchers, as well as the
broader community of Genentech scientists, who are together seeking
novel therapies for unmet medical needs. Much of the software will be
developed in R, as it is our primary data analysis
environment. Interesting challenges include the scale of the data and
the need for agility in a fast-paced, dynamic research
environment. Publishing of methods and software is encouraged, and
there is potential for collaboration with open-source projects. There
is also opportunity for investigating open scientific problems in
computational biology, such as variant calling, functional assessment
of non-coding transcripts, and the relationship between copy number
variation and expression....

Global Product Development Biometrics Biostatistics (PDBB) at Roche/Genentech plays a key role in successful drug development by contributing expertise to the drug development process from research through entry into humans through regulatory approval and beyond. Biostatisticians collaborate on cross-functional teams with colleagues from Clinical Science, Safety Science, Regulatory Affairs, and other functions.  Statistical Methods and Research is a group of statisticians within PDBB with a mission to enhance our strategic and methodological capabilities. Current areas include portfolio decision-making, quantitative benefit-risk, regulatory statistics, and personalized healthcare, but may be extended to meet business needs.  

Key responsibilities include:

• Provide effective, timely and reliable consultancy across the company on statistical problems

• Engage in research in statistics to improve clinical trial methodology used in the development of company products consistent with corporate priorities and timelines

• Work in collaboration with Biostatistics leadership to identify and prioritize areas of potential impact that need new or improved statistical methods

• Impact drug development science beyond the company in industry forums

• Influence internal and external stakeholders to produce and implement robust drug development strategies 

• Contribute to ensure that PDBB is regarded as highly effective strategic partners in drug development whose prestige extends beyond the company

• Develop and maintain expertise in at least one core area of biostatistics and serve as an advisor to other biostatisticians and PD leadership

...

Scientist/Sr. Scientist (Department of Immunology)

 

The Department of Immunology in Genentech Research is seeking a highly motivated Scientist /Senior Scientist to lead an effort in developing novel therapies for the treatment of various autoimmune diseases with unmet medical needs. The successful candidate will head a research group with the mission to identify and pursue therapeutic ideas. The candidate will also lead the effort to translate these ideas to therapeutic approaches for clinical development through the collaboration with other groups and departments,. In addition, the candidate will perform cutting-edge research in immunology to discover novel pathways and mechanisms that contribute to the pathogenesis of diseases and will publish impactful papers on this research.

...

Lab: Bob Lazarus
http://www.gene.com/scientists/our-scientists/bob-lazarus

Responsibilities:
A postdoctoral position is available in the Department of Early Discovery Biochemistry to investigate biochemical aspects of protein/protein and protein/ligand structure function relationships.  Areas of interest include proteases and pseudoproteases, molecular basis of protein/protein interactions, protein scaffolds, phage display technology and will involve collaborative interactions in a multidisciplinary group.  Specific projects include ongoing aspects of HGF/Met signaling, zymogen activation, new targets in pathways of cancer biology, neurobiology, immunology and infectious disease.
...

The ERP Demand & Production Services team is part of the ERP Demand-to-Supply (D2S) team within the Pharma Informatics Shared Platforms & Applications - ERP organization. This global team provides SAP and non-SAP-based solutions and services to our Global Supply Chain (Clinical & Commercial) business function. These solutions include: SAP’s APO (Advanced Planner & Optimizer), SNC (Supplier Network Collaboration), OER (Object Event Repository), AII (Auto-ID Infrastructure), and other vendor and custom solutions, along with integration to various manufacturing and other supply chain solutions.

The Head of ERP Demand & Production Services will provide global perspective and partnership and leverage knowledge across the Roche Group in order to better enable our Supply Chain business to achieve their goals. They will also drive customer demand management, people management,  project management, solution development, maintenance, enhancement,  and operational support. In collaboration with the business, they will develop strategies and plans that maximize the ROI from the use of our solutions.

The Head of ERP Demand & Production Services is accountable for the management and leadership of a team of IT professionals located in Basel, Switzerland and South San Francisco, California, USA, along with the management of shared services resources in Poland and outsource resources - both onsite and offsite. This position can be based in Basel, Switzerland or South San Francisco, California.

As a member of the ERP D2S Leadership team, the Head of ERP Demand & Production Services will: 

• Develop, manage, communicate, and plan effectively to ensure alignment with, and clear understanding of strategic and operational goals of our customers.
• Collaborate  with IT colleagues to ensure that workforce plans, vendor management, budget management, customer change management, staff performance management and other internal processes are conducted professionally and in the best interests of our customers, teams, and other stakeholders.
• Keep abreast of technical developments that may have application in the Pharma / biotech  industry, and promote the use of those that provide strategic business benefits.
• Govern, prioritize, and deliver a portfolio of projects that are aligned with the our business strategy and technology roadmaps.
• Ensure team actively manages incidents, service requests, and change queues in compliance with Roche processes.

...

Group Market Planning Manager Global Product Strategy

Leads a team of 3 International Business Analysts (IBA) that participates actively in global commercial planning efforts by providing unbiased, objective, in-depth information about current and future markets, product performance, customers, and competitors. Additionally, he or she identifies critical business issues and opportunities for growth, collaborates with Roche/Genentech teams, and works to embed an external market point-of view into the strategic direction of the company. This individual will be both a manager and an individual contributor.
This role is a global role based in South San Francisco and he or she is required to travel nationally and internationally.

Key Accountabilities

• Provide an objective commercial viewpoint based on an in-depth understanding and analysis of commercial information.
• Lead team to proactively assess external marketplace/other related factors to support strategic decision-making
• Define/oversee various Strategic Analytics projects and other work completed by team
• Ensure provision of strategic insights/recommendations; enabling business¿partners/stakeholders to make the best-informed decisions regarding their strategies, plans, etc.
• Develop/manage operating budgets and other resource requirements
• Hire, develop and oversee the work of direct/indirect reports
• Comply with all laws, regulations and policies that govern the conduct of Roche/Genentech ¿activities
• Business travel, by air or car, is required for regular internal and external business meetings¿
Capabilities:
• Effectively manage a team of highly driven professionals. Motivate, develop, and retain top talent.
• Grasps key issues quickly, understands the "big picture" and links market research findings to larger issues.
• Uses rigorous logic and methods to solve difficult problems with effective solutions.
• Can see hidden problems; looks beyond the obvious and doesn't stop at the first answers.
• Uses creativity and ingenuity to develop solutions to complex problems, formulates strategies and approaches which may fall outside historical norms.
• Strong commitment to quality. Consistently and thoroughly reviews work for accuracy before sharing with a wider audience. Delivers final products that are well vetted and reliable.
• Demonstrates persuasive written and verbal communication skills. Is effective in a variety of presentation settings. Is comfortable around higher management.
• Can deal with ambiguity and act without having the total picture, is able to effectively pose questions in order to “tease out” information required for decision-making. Can handle risk and uncertainty
...

A Senior Scientist/Associate Director position is available for a highly motivated and innovative scientist with strong leadership and collaborative skills to join our antibody drug conjugation (ADC) program.  Candidates should have extensive experience in protein and antibody conjugations and be a demonstrated thought leader in the ADC field so that they will be able to make immediate contributions to a vibrant and productive program undergoing expansion at this time. The successful candidate will interface with both chemist and biologist in developing new technologies for the production of ADCs as well as optimizing current strategies. The position allows the successful candidate to play a pivotal role in augmenting Genentech’s strong clinical pipeline of new therapeutic ADC candidates.

 

...

A post-doctoral research fellow position isavailable in the Late Stage Pharmaceutical Development group to investigate thetemperature and concentration dependence of protein interactions in solutionand cryogenic conditions. Many monoclonal antibody (MAb) products are developedas high concentration solutions, and have been observed to present a range ofissues (aggregation, precipitation, phase separation) on storage. Thetemperature dependence of intermolecular interactions between proteins andother solution components remains poorly understood, in particular in cyro-concentratedconditions. The objective of the post-doctoral research fellow will be to characterizethe temperature dependent interactions of antibodies in both liquid and frozen glassystates, using a variety of biophysical techniques and novel experimentalapproaches to gain understanding of the underlying molecular basis of theprotein and solvent interactions that result in a variety of bulk solutionbehaviors.

...