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Scientist Profile

Andrew C. Chan

Senior Vice President
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"Innovation requires an open mind and continued challenging of current paradigms. Discovery requires action based on innovation."
 

I joined Genentech in 2001 as senior director of immunology and antibody engineering, was named vice president and senior vice president of Research- Immunology in 2003 and 2007, respectively. In 2010, I was appointed senior vice president- Research Biology and oversee our major focus areas of oncology, immunology, neuroscience, and infectious disease, as well as investigation into new scientific opportunities.

I decided to join Genentech because it permitted me to combine my interests in basic discovery research with my translational interests in understanding the underlying pathogenesis of human autoimmune and inflammatory disorders. I was drawn to Genentech because of its grassroots scientist-driven environment where scientific rigor, innovation and collaboration intertwine basic research and translational medicine and challenge the intellect to discover impactful innovative therapies for significant medical problems.

Technological advances have greatly increased our abilities to probe human diseases and to dissect and characterize their heterogeneous phenotypes. Development of impactful therapies requires the redefinition of heterogeneous clinical syndromes/diseases into distinct patient subsets whose underlying disease is driven by a dominant molecular pathogenic pathway. These transformational redefinitions of clinical syndromes enable us to develop and match the appropriate therapies for a given patient so that they derive greatest clinical benefit for their disease.

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My Focus

Much of my current focus is to ensure that we are at the forefront in discovering new biologies, dissecting the heterogeneous causes of human disease, and thinking about new scientific venues by which these dominant pathways of disease can be attacked.

Our success requires rigorous scientific investigation into human biology and disease, balanced with innovative basic discovery to reveal novel biologies. Hence, much of my current focus is to ensure that we are at the forefront in discovering new biologies, dissecting the heterogeneous causes of human disease, and thinking about new scientific venues by which these dominant pathways of disease can be attacked.

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Publications & Recognition
  • PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background.
  • J Immunol 2009 Apr 1; 182(7): 4093-106.
  • Zikherman J, Hermiston M, Steiner D, Hasegawa K, Chan A, Weiss A.
  • View Abstract on PubMed
  • A specificity map for the PDZ domain family.
  • PLoS Biol 2008 Sep 30; 6(9): e239.
  • Tonikian R, Zhang Y, Sazinsky SL, Currell B, Yeh JH, Reva B, Held HA, Appleton BA, Evangelista M, Wu Y, Xin X, Chan AC, Seshagiri S, Lasky LA, Sander C, Boone C, Bader GD, Sidhu SS.
  • View Abstract on PubMed
  • Regulation of a late phase of T cell polarity and effector functions by Crtam.
  • Cell 2008 Mar 7; 132: 846-59.
  • Yeh JY, Sidhu SS, Chan AC.
  • View Abstract on PubMed
 
View All Publications & Recognition
 
  • University of California, San Francisco
  • Department of Medicine, Division of Rheumatology, Associate Clinical Professor
  • 2004-present
  • Washington University School of Medicine
  • Howard Hughes Medical Institute, Associate Investigator
  • 2000-2001
  • Washington University School of Medicine
  • Departments of Internal Medicine and Pathology, Division of Rheumatology, Associate Professor
  • 1998-2001
  • Washington University School of Medicine
  • Departments of Internal Medicine and Pathology, Division of Rheumatology, Assistant Professor
  • 1994-1998
  • Washington University School of Medicine
  • Howard Hughes Medical Institute, Assistant Investigator
  • 1994-1999
  • Washington University, Barnes Hospital
  • Department of Internal Medicine, Attending Physician
  • 1994-2001
  • University of California, San Francisco
  • Long-Moffitt Hospital, Department of Medicine, Attending Physician
  • 1992-1993
  • University of California, San Francisco
  • Department of Medicine, Division of Rheumatology, Assistant Adjunct Professor
  • 1992-1993
  • University of California, San Francisco
  • Department of Medicine, Division of Rheumatology, Clinical Fellow
  • 1989-1990
  • Washington University School of Medicine
  • Barnes Hospital, Department of Internal Medicine, Intern and Resident
  • 1986-1989
  • Washington University School of Medicine
  • Department of Cellular and Developmental Biology, M.D., Ph.D.
  • 1980-1986
  • Northwestern University
  • Department of Chemistry, M.S., B.A.
  • 1976-1980
Publications & Recognition
  • PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background.
  • J Immunol 2009 Apr 1; 182(7): 4093-106.
  • Zikherman J, Hermiston M, Steiner D, Hasegawa K, Chan A, Weiss A.
  • View Abstract on PubMed
  • A specificity map for the PDZ domain family.
  • PLoS Biol 2008 Sep 30; 6(9): e239.
  • Tonikian R, Zhang Y, Sazinsky SL, Currell B, Yeh JH, Reva B, Held HA, Appleton BA, Evangelista M, Wu Y, Xin X, Chan AC, Seshagiri S, Lasky LA, Sander C, Boone C, Bader GD, Sidhu SS.
  • View Abstract on PubMed
  • Regulation of a late phase of T cell polarity and effector functions by Crtam.
  • Cell 2008 Mar 7; 132: 846-59.
  • Yeh JY, Sidhu SS, Chan AC.
  • View Abstract on PubMed
  • A biosynthetic pathway for anandamide.
  • Proc Natl Acad Sci USA 2006 Sep 5; 103(36): 13345-50.
  • Liu J, Wang L, Harvey-White J, Osei-Hyiaman D, Razdan R, Gong Q, Chan AC, Zhou Z, Huang BX, Kim HY, Kunos, G.
  • View Abstract on PubMed
  • Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis.
  • Science 2006 Aug 11; 313(5788): 839-42.
  • Foger N, Rangell L, Danilenko DM, Chan AC.
  • View Abstract on PubMed
  • The role of receptor internalization in CD95 signaling.
  • EMBO J 2006 Mar 8; 25(5): 1009-23.
  • Lee KH, Feig C, Tchikov V, Schickel R, Hallas C, Schutze S, Peter ME, Chan AC.
  • View Abstract on PubMed
  • Pathogenic roles of B cells in human autoimmunity; insights from the clinic.
  • Immunity 2004 May; 20(5): 517-27.
  • Martin F, Chan AC.
  • View Abstract on PubMed
  • PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells.
  • Science 2004 Jan 30; 303(5658): 685-9.
  • Hasegawa K, Martin F, Huang G, Tumas D, Diehl L, Chan AC.
  • View Abstract on PubMed
  • Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype.
  • Nature 2003 Jan 23; 421(6921): 388-92.
  • Kemper C, Chan AC, Green JM, Brett KA, Murphy KM, Atkinson JP.
  • View Abstract on PubMed
  • BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins.
  • EMBO J 2002 Dec 2; 21(23): 6461-72.
  • Chiu CW, Dalton M, Ishiai M, Kurosaki T, Chan AC.
  • View Abstract on PubMed
  • The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways.
  • Mol Cell Biol 2002 Apr; 22(8): 2524-35.
  • Kabak S, Skaggs BJ, Gold MR, Affolter M, West KL, Foster MS, Siemasko K, Chan AC, Aebersold R, Clark MR.
  • View Abstract on PubMed
  • T cell receptor signaling precedes immunological synapse formation.
  • Science 2002 Feb 22; 295(5559): 1539-42.
  • Lee KH, Holdorf AD, Dustin ML, Chan AC, Allen PM, Shaw AS.
  • View Abstract on PubMed
  • Inefficient ZAP-70 phosphorylation and decreased thymic selection in vivo result from inhibition of NF-kappaB/Rel.
  • J Immunol 2001 Nov 15; 167(10): 5628-35.
  • Mora AL, Stanley S, Armistead W, Chan AC, Boothby M.
  • View Abstract on PubMed
  • Requirement for tyrosine residues 315 and 319 within zeta chain-associated protein 70 for T cell development.
  • J Exp Med 2001 Aug 20; 194(4): 507-18.
  • Gong Q, Jin X, Akk AM, Foger N, White M, Gong G, Wardenburg JB, Chan AC.
  • View Abstract on PubMed
  • Epstein-Barr virus latent membrane protein 2A (LMP2A) employs the SLP-65 signaling module.
  • J Exp Med 2001 Aug 6; 194(3): 255-64.
  • Engels N, Merchant M, Pappu R, Chan AC, Longnecker R, Wienands J.
  • View Abstract on PubMed
  • Disruption of T cell signaling networks and development by Grb2 haploid insufficiency.
  • Nat Immunol 2001 Jan; 2(1): 29-36.
  • Gong Q, Cheng AM, Akk AM, Alberola-Ila J, Gong G, Pawson T, Chan AC.
  • View Abstract on PubMed
  • An essential role for BLNK in human B cell development.
  • Science 1999 Dec 3; 286(5446): 1954-7
  • Minegishi Y, Rohrer J, Coustan-Smith E, Lederman HM, Pappu R, Campana D, Chan AC, Conley ME.
  • View Abstract on PubMed
  • Requirement for B cell linker protein (BLNK) in B cell development.
  • Science 1999 Dec 3; 286(5446): 1949-54.
  • Pappu R, Cheng AM, Li B, Gong Q, Chiu C, Griffin N, White M, Sleckman BP, Chan AC.
  • View Abstract on PubMed
  • BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells.
  • Immunity 1999 Jan; 10(1): 117-25
  • Ishiai M, Kurosaki M, Pappu R, Okawa K, Ronko I, Fu C, Shibata M, Iwamatsu A, Chan AC, Kurosaki T.
  • View Abstract on PubMed
  • Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76.
  • Immunity 1998 Nov; 9(5): 607-16.
  • Bubeck Wardenburg J, Pappu R, Bu JY, Mayer B, Chernoff J, Straus D, Chan AC.
  • View Abstract on PubMed
  • BLNK: a central linker protein in B cell activation.
  • Immunity 1998 Jul; 9(1): 93-103.
  • Fu C, Turck CW, Kurosaki T, Chan AC.
  • View Abstract on PubMed
  • The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling.
  • Proc Natl Acad Sci U S A 1997 Sep 2; 94(18): 9797-801.
  • Cheng AM, Negishi I, Anderson SJ, Chan AC, Bolen J, Loh DY, Pawson T.
  • View Abstract on PubMed
  • Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function.
  • J Biol Chem 1996 Aug 16; 271(33): 19641-4.
  • Wardenburg JB, Fu C, Jackman JK, Flotow H, Wilkinson SE, Williams DH, Johnson R, Kong G, Chan AC, Findell PR.
  • View Abstract on PubMed
  • Essential role for ZAP-70 in both positive and negative selection of thymocytes.
  • Nature 1995 Aug 3; 376(6539): 435-8.
  • Negishi I, Motoyama N, Nakayama K, Nakayama K, Senju S, Hatakeyama S, Zhang Q, Chan AC, Loh DY.
  • View Abstract on PubMed
  • Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function.
  • EMBO J 1995 Jun 1; 14(11): 2499-508.
  • Chan AC, Dalton M, Johnson R, Kong GH, Wang T, Thoma R, Kurosaki T.
  • View Abstract on PubMed
  • ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency.
  • Science 1994 Jun 10; 264(5165): 1599-601.
  • Chan AC, Kadlecek TA, Elder ME, Filipovich AH, Kuo WL, Iwashima M, Parslow TG, Weiss A.
  • View Abstract on PubMed
  • Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase.
  • Science 1994 Jun 10; 264(5165): 1596-9.
  • Elder ME, Lin D, Clever J, Chan AC, Hope TJ, Weiss A, Parslow TG.
  • View Abstract on PubMed
  • ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain.
  • Cell 1992 Nov 13; 71(4): 649-62.
  • Chan AC, Iwashima M, Turck CW, Weiss A.
  • View Abstract on PubMed
  • The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein.
  • Proc Natl Acad Sci U S A 1991 Oct 15; 88(20): 9166-70.
  • Chan AC, Irving BA, Fraser JD, Weiss A.
  • View Abstract on PubMed
  • Identification and partial characterization of the secreted form of the fourth component of human complement: evidence that it is different from major plasma form.
  • Proc Natl Acad Sci U S A 1983 Jan; 80(1): 268-72.
  • Chan AC, Mitchell KR, Munns TW, Karp DR, Atkinson JP.
  • View Abstract on PubMed
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Awards & Honors
  • Special Recognition Award for Mentoring Graduate Students Washington University
    2000
  • American College of Rheumatology Investigator Award
    1993
  • American College of Rheumatology Senior Scholar Award
    1991
  • American Foundation of Clinical Research Award
    1991
  • Association of American Physicians
    2009
  • Henry Kunkel Society
    2006
  • American Society for Clinical Investigation
    1999
  • Pew Scholars Program for the Biomedical Sciences
    1995
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Ellen Filvaroff, Senior Scientist and Alex Avardo, Receipent of Free Medicine From the Genentech® Access to Care Foundation, on the cover of Genentech's 2006 Annual Report.