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Scientist Profile

Andrew Peterson

Associate Director: Molecular Biology
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"The environment in Research is one in which decision-making is logical, science-based and transparent, and the interactions are collegial. Although these things seem simple and obvious, having them in place allows us to focus on the excitement of science and how to translate biology into effective therapeutics."

I visited Genentech in 1989 and gave a seminar on CD4 and HIV interactions. That was my first and only direct exposure to the environment here for quite some time but it made enough of a lasting impression that I was very excited when the opportunity to come here as a scientist arose many years later.

 
My Focus

We have primarily been using neural development as our biological paradigm for these investigations, but are beginning to branch out into metabolism. In addition to the largely postdoctoral based efforts of my own lab, I am very involved in a number of projects in Molecular Biology that are also based in murine genetics.

 
Publications & Recognition
  • The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis.
  • Sci Signal 2009 Nov 3; 2(95): ra70.
  • Ashique AM, Choe Y, Karlen M, May SR, Phamluong K, Solloway MJ, Ericson J, Peterson AS.
  • View Abstract on PubMed
  • Retinoic acid from the meninges regulates cortical neuron generation.
  • Cell 2009 Oct 30; 139(3): 597-609.
  • Siegenthaler JA, Ashique AM, Zarbalis K, Patterson KP, Hecht JH, Kane MA, Folias AE, Choe Y, May SR, Kume T, Napoli JL, Peterson AS, Pleasure SJ.
  • View Abstract on PubMed
  • The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.
  • Curr Biol 2009 Aug 11; 19(15): 1320-6.
  • Endoh-Yamagami S, Evangelista M, Wilson D, Wen X, Theunissen JW, Phamluong K, Davis M, Scales SJ, Solloway MJ, de Sauvage FJ, Peterson AS.
  • View Abstract on PubMed
 
View All Publications & Recognition
 
  • Ernest Gallo Clinic and Research Center
  • Principal Investigator
  • 1999-2005
  • University of California at San Francisco, California, Department of Neurology
  • Assistant Professor in Residence
  • 1999-2005
  • Duke University Medical Center, Durham North Carolina
  • Adjunct Assistant Professor of Genetics
  • 1999-2005
  • Duke University Medical Center, Durham, North Carolina, Department of Genetics and Department of Neurobiology
  • Assistant Professor
  • 1994-1999
  • University of California, San Francisco, California, Department of Physiology
  • Postdoctoral Fellow
  • 1988-1994
  • Harvard University
  • Genetics, Ph.D.
  • 1982-1988
  • University of Washington, Biological Sciences
  • B.S.
  • 1978-1982
Publications & Recognition
  • The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis.
  • Sci Signal 2009 Nov 3; 2(95): ra70.
  • Ashique AM, Choe Y, Karlen M, May SR, Phamluong K, Solloway MJ, Ericson J, Peterson AS.
  • View Abstract on PubMed
  • Retinoic acid from the meninges regulates cortical neuron generation.
  • Cell 2009 Oct 30; 139(3): 597-609.
  • Siegenthaler JA, Ashique AM, Zarbalis K, Patterson KP, Hecht JH, Kane MA, Folias AE, Choe Y, May SR, Kume T, Napoli JL, Peterson AS, Pleasure SJ.
  • View Abstract on PubMed
  • The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.
  • Curr Biol 2009 Aug 11; 19(15): 1320-6.
  • Endoh-Yamagami S, Evangelista M, Wilson D, Wen X, Theunissen JW, Phamluong K, Davis M, Scales SJ, Solloway MJ, de Sauvage FJ, Peterson AS.
  • View Abstract on PubMed
  • A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development.
  • PLos Biol 2004 Aug; 2(8): E219.
  • Zarbalis K, May SR, Shen Y, Ekker M, Rubenstein JL, Peterson AS.
  • View Abstract on PubMed
  • Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis.
  • Development 2004 Jan; 131(1): 3-14.
  • Zoltewicz JS, Stewart NJ, Leung R, Peterson AS.
  • View Abstract on PubMed
  • FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse.
  • Proc Natl Acad Sci USA 2001 Nov 20; 98(24): 13796-801.
  • Hentges KE, Sirry B, Gingeras AC, Sarbassov D, Sonenberg N, Sabatini D, Peterson AS.
  • View Abstract on PubMed
  • Nonselective and G betagamma-insensitive weaver K+ channels.
  • Science 1996 Jun 28; 272(5270): 1950-3.
  • Navarro B, Kennedy ME, Velimirovíc B, Bhat D, Peterson AS, Clapham DE.
  • View Abstract on PubMed
  • A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation.
  • Nat Genet 1995 Oct; 11(2): 126-9.
  • Patil N, Cox DR, Bhat D, Faham M, Myers RM, Peterson AS.
  • View Abstract on PubMed
  • Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel.
  • Science 1991 Oct 18; 254(5030): 432-7.
  • Maricq AV, Peterson AS, Brake AJ, Myers RM, Julius D.
  • View Abstract on PubMed
  • Genetic analysis of monoclonal antibody and HIV binding sites on the human lymphocyte antigen CD4.
  • Cell 1988 Jul 1;54(1): 65-72.
  • Peterson A, Seed B.
  • View Abstract on PubMed
  • Functional analysis of a cytoplasmic domain-deleted mutant of the CD4 molecule..
  • J Immunol 1988 Jul 1; 141(1): 49-54.
  • Sleckman BP, Peterson A, Foran JA, Gorga JC, Kara CJ, Strominger JL, Burakoff SJ, Greenstein JL.
  • View Abstract on PubMed
  • Expression of the T-cell surface molecule CD2 and an epitope-loss CD2 mutant to define the role of lymphocyte function-associated antigen 3 (LFA-3) in T-cell activation.
  • Proc Natl Acad Sci USA 1988 Feb; 85(4): 1194-8.
  • Bierer BE, Peterson A, Barbosa J, Seed B, Burakoff SJ.
  • View Abstract on PubMed
  • Monoclonal antibody and ligand binding sites of the T cell erythrocyte receptor (CD2).
  • Nature 1987 Oct 29-Nov 4; 329(6142): 842-6.
  • Peterson A, Seed B.
  • View Abstract on PubMed
  • Expression and function of CD4 in a murine T-cell hybridoma.
  • Nature 1987 Jul 23-29; 328(6128): 351-3.
  • Sleckman BP, Peterson A, Jones WK, Foran JA, Greenstein JL, Seed B, Burakoff SJ.
  • View Abstract on PubMed
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Awards & Honors
  • Sandoz Scholar--1995
  • Basil O'Connor Starter Scholar Award--1995
  • Jane Coffin Childs Postdoctoral Fellowship--1988
  • National Science Foundation Graduate Fellowship--1982

Andrew Peterson, Senior Scientist and Alex Avardo, Receipent of Free Medicine From the Genentech® Access to Care Foundation, on the cover of Genentech's 2006 Annual Report.