David Hackos
Scientist: Neuroscience-
My Keywords
Research, Neuroscience -
My Department
Research
I started my lab at Genentech in June 2009. Prior to this, I was a scientist at Roche in Palo Alto studying ion channels involved in inflammatory disorders. Being a scientist at Genentech is a dream job for me. It has the perfect blend of the practical world of drug discovery and the scientific rigor of an academic institution. Prior to Roche and Genentech, I was a senior scientist at Renovis, a small biotech in South San Francisco, where I worked in the areas of pain and inflammation.
My Focus
My lab focuses on ion channels and their roles in neurologic disease. Ion channels are membrane proteins that have the ability to regulate the flow of ions across the cell's membrane. By rapidly opening and closing in precise ways, ion channels play a pivotal role in the functioning of the nervous system. Under pathological conditions, such as those that occur in the context of neurodegenerative diseases, ion channels can cause dysfunction and damage to the neurons that express them. The goal of my work is to identify ion channels that open inappropriately under these pathological conditions in the hope of finding novel targets for neurodegenerative disease.
A second area of interest in my lab are the ion channels that are involved in pain. Pain-sensing neurons express a unique set of ion channels that are not found in any other cell in the body. These channels are involved in the detection of nociceptive stimuli as well as the transduction of nociceptive information into the CNS. We are working to develop drugs capable of selectively blocking these ion channels to inhibit pain without causing the side-effects found in currently available pain medications.
Publications & Recognition
- Constitutive activation of the Shaker Kv channel.
- J Gen Physiol 2003 Nov; 122(5): 541-56.
- Sukhareva M, Hackos DH, Swartz KJ.
- View Abstract on PubMed
- Scanning the intracellular S6 activation gate in the shaker K+ channel.
- J Gen Physiol 2002 Jun; 119(6): 521-32.
- Hackos DH, Chang TH, Swartz KJ.
- View Abstract on PubMed
- alpha-helical structural elements within the voltage-sensing domains of a K(+) channel.
- J Gen Physiol 2000 Jan; 115(1): 33-50.
- Li-Smerin Y, Hackos DH, Swartz KJ.
- View Abstract on PubMed
- Roche Palo Alto
- Research Scientist II
- 2007-2009
- National Institutes of Health, National Institute of Neurological Disorders and Stroke
- Postdoctoral Training
- 1998-2001
- University of California, San Francisco, Department of Biophysics
- Ph.D.
- 1998
- Johns Hopkins University, Department of Biophysics
- B.A.
- 1991
Publications & Recognition
- Constitutive activation of the Shaker Kv channel.
- J Gen Physiol 2003 Nov; 122(5): 541-56.
- Sukhareva M, Hackos DH, Swartz KJ.
- View Abstract on PubMed
- Scanning the intracellular S6 activation gate in the shaker K+ channel.
- J Gen Physiol 2002 Jun; 119(6): 521-32.
- Hackos DH, Chang TH, Swartz KJ.
- View Abstract on PubMed
- alpha-helical structural elements within the voltage-sensing domains of a K(+) channel.
- J Gen Physiol 2000 Jan; 115(1): 33-50.
- Li-Smerin Y, Hackos DH, Swartz KJ.
- View Abstract on PubMed
- A localized interaction surface for voltage-sensing domains on the pore domain of a K+ channel.
- Neuron 2000 Feb; 25(2): 411-23
- Li-Smerin Y, Hackos DH, Swartz KJ.
- View Abstract on PubMed
- Fraction of the dark current carried by Ca(2+) through cGMP-gated ion channels of intact rod and cone photoreceptors
- J Gen Physiol 2000 Dec; 116(6): 735-54.
- Ohyama T, Hackos DH, Frings S, Hagen V, Kaupp UB, Korenbrot JI.
- View Abstract on PubMed
- Determination of fractional calcium ion current in cyclic nucleotide-gated channels
- Methods Enzymol 2000; 315:797-817.
- Frings S, Hackos DH, Dzeja C, Ohyama T, Hagen V, Kaupp UB, Korenbrot JI.
- View Abstract on PubMed
- Divalent cation selectivity is a function of gating in native and recombinant cyclic nucleotide-gated ion channels from retinal photoreceptors.
- J Gen Physiol 1999 Jun; 113(6): 799-818.
- Hackos DH, Korenbrot JI.
- View Abstract on PubMed
- Calcium modulation of ligand affinity in the cyclic GMP-gated ion channels of cone photoreceptors
- J Gen Physiol 1997 Nov; 110(5): 515-28
- Hackos DH, Korenbrot JI
- View Abstract on PubMed
- Identification of the molecular trigger for allosteric activation in glycogen phosphorylase
- Nat Struct Biol 1994 May; 1(5): 327-33
- Browner MF, Hackos D, Fletterick R.
- View Abstract on PubMed
Awards & Honors
-
National Institute of General Medicine Studies, Pharmaceutical Research Associate Program Fellowship Award 1999-2001
-
Achievement Rewards for College Scientists Foundation Scholarship Award 1997-1998
-
Howard Hughes Medical Institute Pre-doctoral Fellowship 1992-1997
-
Howard Hughes Medical Institute Undergraduate Fellowship 1990-1991
