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Scientist Profile

Hilary Clark

Senior Scientist: Bioinformatics & Computational Biology
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"I love to continually learn new areas of biological research that intersect in powerful ways, making significant contributions to our understanding of human disease."
 

I joined Genentech in 1999 after two years at another biotech company, Genetics Institute (now merged with Wyeth Pharmaceuticals). I chose to join biotech in order to do research that can more directly benefit patients. Genentech has certainly been an exciting place to do research. There are so many opportunities for pursuing new ideas.

 
 
My Focus

I have a joint appointment with the Immunology Department and have become involved with many of their research efforts, from early discovery of novel genes, microarray analysis to identifying gene signatures in immune cell subsets and disease biopsies. Most recently, we have been using human genetics to identify key risk genes for asthma and Crohn's disease. I have gotten the most satisfaction from contributing to several late-stage research projects that have moved into Development and will soon be in clinical trials.

 
Publications & Recognition
  • Characterisation of genome wide expression in colonic and terminal ileal biopsies in Crohn's disease
  • Inflammatory Bowel Diseases 2010
  • Noble CL, Abbas AR, Lees CW, Cornelius J, Toy K, Modrusan Z, Clark H, Arnott I, Penman ID, Satsangi J, Diehl L
  • Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1
  • J Exp Med 2010 Jan 18; 207(1): 7-16, S1-5
  • Xi H, Katschke KJ Jr, Helmy KY, Wark PA, Kljavin N, Clark H, Eastham-Anderson J, Shek T, Roose-Girma M, Ghilardi N, van Lookeren Campagne M
  • View Abstract on PubMed
  • Deconvolution of blood microarray data identifies cellular activation patterns in systemic lupus erythematosus
  • PLoS One 2009 Jul 1; 4(7): e6098
  • D. Seshasayee, W.P. Lee, M. Zhou, J. Shu, E. Suto, J. Zhang, W.Y. Lin, L. Diehl, C. Austin, G. Meng, M. Tan, S. Bullens, S. Seeber, M. Fuentes, F. Rebers, L. Miller, J. Gerriets, L. Wu, S. Hymowitz and F. Martin
  • View Abstract on PubMed
 
View All Publications & Recognition
 
  • Harvard Medical School
  • Postdoctoral Research
  • 1993-1994
  • University of California at Berkeley
  • Ph.D. in Genetics
  • 1993
  • San Francisco State University
  • B.S.
  • 1988
  • University of San Francisco
  • B.S.
  • 1982
Publications & Recognition
  • Characterisation of genome wide expression in colonic and terminal ileal biopsies in Crohn's disease
  • Inflammatory Bowel Diseases 2010
  • Noble CL, Abbas AR, Lees CW, Cornelius J, Toy K, Modrusan Z, Clark H, Arnott I, Penman ID, Satsangi J, Diehl L
  • Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1
  • J Exp Med 2010 Jan 18; 207(1): 7-16, S1-5
  • Xi H, Katschke KJ Jr, Helmy KY, Wark PA, Kljavin N, Clark H, Eastham-Anderson J, Shek T, Roose-Girma M, Ghilardi N, van Lookeren Campagne M
  • View Abstract on PubMed
  • Deconvolution of blood microarray data identifies cellular activation patterns in systemic lupus erythematosus
  • PLoS One 2009 Jul 1; 4(7): e6098
  • D. Seshasayee, W.P. Lee, M. Zhou, J. Shu, E. Suto, J. Zhang, W.Y. Lin, L. Diehl, C. Austin, G. Meng, M. Tan, S. Bullens, S. Seeber, M. Fuentes, F. Rebers, L. Miller, J. Gerriets, L. Wu, S. Hymowitz and F. Martin
  • View Abstract on PubMed
  • The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells
  • Nat Immunol 2009 Jan; 10(1): 48-57. Epub 2008 Nov 16
  • Yu X, Harden K, Gonzalez L, Francesco M, Chiang E, Irving B, Tom I, Ivelja S, Refino CJ, Clark H, Eaton D, Grogan JL
  • View Abstract on PubMed
  • Regional Variation in Gene Expression in the Healthy Colon is Dysregulated in Ulcerative Colitis
  • Gut 2008 Oct; 57(10): 1398-405. Epub 2008 Jun 3
  • Noble CL, Abbas AR, Cornelius J, Lees CW, Ho GT, Toy K, Modrusan Z, Pal N, Zhong F, Chalasani S, Clark H, Arnott ID, Penman ID, Satsangi J, Diehl L
  • View Abstract on PubMed
  • Gene signatures reflect the marked heterogeneity of tissue-resident macrophages
  • Immunol Cell Biol 2008 Mar-Apr; 86(3): 246-54. Epub 2007 Nov 13
  • Gorgani NN, Ma Y, Clark HF
  • View Abstract on PubMed
  • Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci
  • Proc Natl Acad Sci U S A 2007 Sep 11; 104(37): 14747-52
  • Raelson JV, Little RD, Ruether A, Fournier H, Paquin B, Van Eerdewegh P, Bradley WE, Croteau P, Nguyen-Huu Q, Segal J, Debrus S, Allard R, Rosenstiel P, Franke A, Jacobs G, Nikolaus S, Vidal JM, Szego P, Laplante N, Clark HF, Paulussen RJ, Hooper JW, Keith TP, Belouchi A, Schreiber S
  • View Abstract on PubMed
  • Immune response in silico (IRIS): immune-specific genes identified from a compendium of microarray expression data
  • Genes Immun 2005 Jun; 6(4): 319-31
  • Abbas AR, Baldwin D, Ma Y, Ouyang W, Gurney A, Martin F, Fong S, van Lookeren Campagne M, Godowski P, Williams PM, Chan AC, Clark HF
  • View Abstract on PubMed
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment
  • Genome Res 2003 Oct; 13(10): 2265-70
  • Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A
  • View Abstract on PubMed
  • Developmental regulation of Zbu1, a DNA-binding member of the SWI2/SNF2 family
  • Dev Biol 1997 Mar 15; 183(2): 166-82
  • Gong X, Kaushal S, Ceccarelli E, Bogdanova N, Neville C, Nguyen T, Clark H, Khatib ZA, Valentine M, Look AT, Rosenthal N
  • View Abstract on PubMed
  • Dachsous encodes a member of the cadherin superfamily that controls imaginal disc morphogenesis in Drosophila
  • Genes Dev 1995 Jun 15; 9(12): 1530-42
  • Clark HF, Brentrup D, Schneitz K, Bieber A, Goodman C, Noll M
  • View Abstract on PubMed
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Awards & Honors
  • Phi Beta Kappa
  • B.S. Summa Cum Laude
  • National Science Foundation Honorable Mention

Ellen Filvaroff, Senior Scientist and Alex Avardo, Receipent of Free Medicine From the Genentech® Access to Care Foundation, on the cover of Genentech's 2006 Annual Report.