Jennie Lill
Senior Scientist, Protein Chemistry
"My inspiration comes from the enthusiasm and dedication of my team and collaborators. I am extremely proud to be part of this rewarding endeavor and excited to see our current early stage drug discovery research & technology development projects come to fruition."
-
My Keywords
Protein Chemistry, Bioinformatics -
My Department
Protein Chemistry
I decided to pursue a career at Genentech as it presented the opportunity to join a world-leading research environment.
As a member of the Protein Chemistry department, I have become involved in many projects encompassing a variety of disciplines and cutting-edge drug discovery research topics. In addition to these collaborations, I have also had the opportunity to initiate novel biochemical and mass spectrometric technology development projects.
My Focus
My lab is focused on developing methods for the high throughput and sensitive characterization of proteins, and the isolation and characterization of post translational modifications to aid in the elucidation of novel intracellular signaling mechanisms and drug discovery efforts.
Our current technological development projects include high throughput antibody de novo sequencing, SUMOylation site mapping protocols and the development of bioinformatic tools too allow us to stream line our data analysis. We are also involved with developing methods using the PTMscan technology licensed from Cell Signaling Technologies to unravel low level signaling pathways to aid in understand cellular signaling events.
Publications & Recognition
- Comparative analysis of techniques to purify plasma membrane proteins
- J Biomol Tech. 2010 Sep;21(3);108-15
- Weekes MP, Antrobus R, Lill JR, Duncan LM, Hor S, Lehner PJ
- View Abstract on PubMed
- Template proteogenomics: sequencing whole proteins using an imperfect database
- Mol Cell Proteomics. 2010 Jun; 9(6):1260-70. Epub 2010 Feb 17
- Castellana NE, Pham V, Arnott D, Lill JR, Bafna V
- View Abstract on PubMed
- Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
- Nature 2010 Jan 7; 463(7277): 103-7.
- Schwickart M, Huang X, Lill JR, Liu J, Ferrando R, French DM, Maecker H, O'Rourke K, Bazan F, Eastham-Anderson J, Yue P, Dornan D, Huang DC, Dixit VM
- View Abstract on PubMed
- Nottingham Trent University, Nottingham, U.K.
- Ph.D
- 1997-2000
- European Masters in Biotechnology, Nottingham, U.K.
- M.Sc
- 1996-1997
- University of Warwick, U.K., Biological Sciences
- B.Sc Honors
- 1993-1996
Publications & Recognition
- Comparative analysis of techniques to purify plasma membrane proteins
- J Biomol Tech. 2010 Sep;21(3);108-15
- Weekes MP, Antrobus R, Lill JR, Duncan LM, Hor S, Lehner PJ
- View Abstract on PubMed
- Template proteogenomics: sequencing whole proteins using an imperfect database
- Mol Cell Proteomics. 2010 Jun; 9(6):1260-70. Epub 2010 Feb 17
- Castellana NE, Pham V, Arnott D, Lill JR, Bafna V
- View Abstract on PubMed
- Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
- Nature 2010 Jan 7; 463(7277): 103-7.
- Schwickart M, Huang X, Lill JR, Liu J, Ferrando R, French DM, Maecker H, O'Rourke K, Bazan F, Eastham-Anderson J, Yue P, Dornan D, Huang DC, Dixit VM
- View Abstract on PubMed
- Cullin-3 Controls Cell-extrinsic Apoptosis Signaling through Stimulatory Ubiquitination of Caspase-8
- Cell. 2009 May 15; 137(4): 721-35. Epub 2009 May 7
- Jin Z, Pitti R, Pham V, Li Y, Lawrence D, Lill J, Ashkenazi A
- View Abstract on PubMed
- Targeting Interferon Alpha Subtypes in Serum: A Comparison of Analytical Approaches to the Detection and Quantitation of Proteins in Complex Biological Matrices
- J Proteome Res. 2009 May 6
- Izrael-Tomasevic A, Phu L, Phung QT, Lill JR, Arnott D
- View Abstract on PubMed
- The double histone acetyltransferase complex ATAC is essential for mammalian development
- Mol Cell Biol 2008 Dec 22
- Guelman S, Kozuka K, Mao Y, Pham V, Solloway MJ, Wang J, Wu J, Lill JR, Zha J
- View Abstract on PubMed
- Automated de novo protein sequencing of monoclonal antibodies
- Nature Biotechnology 2008; 26(12): 1336-8
- Bandeira N, Pham V, Arnott D, Pevzner P, Lill JR
- View Abstract on PubMed
- Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies
- Cell 2008 Aug 22; 134: 668-678
- Newton K, Matsumoto ML, Wertz IE, Kirkpatrick DS, Lill JR, Tan J, Dugger D, Gordon N, Sidhu SS, Fellouse FA, Komuves L, French DM, Ferrando RE, Lam C, Compaan D, Yu C, Bosanac I, Hymowitz SG, Kelley RF, Dixit VM
- View Abstract on PubMed
- Recent developments in microwave-assisted protein chemistries- can this be integrated into the drug discovery and validation process?
- Drug Discovery Today 2008; 13: 1075-1081
- Sandoval WN, Pham VC, Lill JR
- View Abstract on PubMed
- On-PVDF protein digestions for N-terminal sequencing and peptide mass fingerprinting
- In: The protein protocols handbook. 3rd ed. Totowa, New Jersey: Humana Press
- Pham V, Henzel WJ, Lill JR
- Application of microwave-assisted proteomics in biotechnology
- Comb Chem High Throughput Screen. In press 2007.
- Pham V, Sandoval WN, Ingle E, Liu P, Lill JR
- View Abstract on PubMed
- Rapid removal of N-linked oligosaccharides using microwave-assisted enzyme catalyzed deglycosylation
- Int J Mass Spectrom 2007 259(1-3): 117-23
- Sandoval WN, Arellano F, Arnott D, Raab H, Vandlen R, Lill JR
- Microwave-assisted proteomics
- Mass Spectrom Rev 2007 May 1; [Epub]
- Lill JR, Ingle ES, Liu PS, Pham V, Sandoval WN
- View Abstract on PubMed
- De novo proteomic sequencing of a monoclonal antibody raised against OX40 ligand
- Anal Biochem 2006 May 1; 352(1): 77-86
- Pham V, Henzel WJ, Arnott D, Hymowitz S, Sandoval WN, Truong BT, Lowman H, Lill JR
- View Abstract on PubMed
- De novo proteomic sequencing of a monoclonal antibody raised against OX40 ligand
- Anal Biochem 2006 May 1; 352(1): 77-86
- Pham V, Henzel WJ, Arnott D, Hymowitz S, Sandoval WN, Truong BT, Lowman H, Lill JR
- View Abstract on PubMed
- Rapid on-membrane proteolytic cleavage for Edman sequencing and mass spectrometric identification of proteins
- Electrophoresis 2005 Nov; 26(22): 4243-51
- Pham VC, Henzel WJ, Lill JR
- View Abstract on PubMed
- Design and synthesis of AX7574: a microcystin-derived, fluorescent probe for serine/threonine phosphatases
- Bioconjug Chem 2004 Jul-Aug; 15(4): 790-8
- Shreder KR, Liu Y, Nomanhboy T, Fuller SR, Wong MS, Gai WZ, Wu J, Leventhal PS, Lill JR, Corral S
- View Abstract on PubMed
- Proteomic tools for quantitation by mass spectrometry
- Mass Spectrom Rev 2003 May-Jun; 22(3): 182-94
- Lill J
- View Abstract on PubMed
- Electrospray mass spectrometry for the identification of MHC class I-associated peptides expressed on cancer cells
- J Immunol Methods 2002 Apr 1; 262(1-2): 5-19
- Bonner PL, Lill JR, Hill S, Creaser CS, Rees RC
- View Abstract on PubMed
- Characterisation of HLA-A3 restricted peptides from the BCR-ABL fusion protein of the Philadelphia chromosome using nano-electrospray ion trap mass spectrometry
- In: Gelpi J, editor. Advances in Mass Spectrometry. New York: Wiley & Sons; 2001. 15: 637-38
- Creaser CS, Lill JR, Bonner PLR, Hill SC, Rees RC, Christmas SC, Norbury L, Dodi AI, Madrigal JA
- Direct evidence that leukemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein
- Blood 2001 Nov 15; 98(10): 2887-93
- Clark RE, Dodi IA, Hill SC, Lill JR, Aubert G, Macintyre AR, Rojas J, Bourdon A, Bonner PL, Wang L, Christmas SE, Travers PJ, Creaser CS, Rees RC, Madrigal JA
- View Abstract on PubMed
- Nano-electrospray and microbore liquid chromatography-ion trap mass spectrometry studies of copper complexation with MHC restricted peptides
- Analyst 2000 Apr; 125(4): 599-603
- Creaser CS, Lill JR, Bonner PL, Hill SC, Rees RC
- View Abstract on PubMed
Awards & Honors
-
Awarded the Proteometrics Student Travel Award at the 48th American Society of Mass Spectrometry Annual Conference 2000
-
Awarded the Michael Barber Prize at the 24th Annual meeting of the British Mass Spectrometry Society 1999
