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Scientist Profile

John Monroe

Senior Director, ITGR Diagnostics Discovery
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"We are entering the golden age of human immunology as a hypothesis-driven science. In the next 10 years we will witness explosive leaps in our understanding of human immunology at the molecular and genetic levels. Genentech will play a leading role in both efforts and I am proud to be part of its scientific team"

I joined Genentech to help build a group of research scientists that will identify molecular markers that predict which patients will best benefit from biological and small molecule therapeutics. The decision was an easy one; there are very few places that provide opportunities to discover and develop drugs that will benefit patients and at the same time encourage research that will lead to a better understanding of human immunology.

It is a privilege to work with so many talented and dedicated people and for a company that respects the importance of rigorous basic research and fosters innovation in drug design and targets.

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My Focus

My background is in immunology and more specifically, B lymphocyte biology. My current studies reflect these interests and focus on mechanisms controlling the survival and activation of B lymphocytes as well as the cellular and molecular processes that are disrupted in autoimmune and other inflammatory diseases.

In addition, research in our group attempts through the understanding of disease mechanisms to discover biomarkers that will better characterize and subset immune system-mediated diseases and thereby facilitate identification of new therapeutic targets and the appropriate selection of patients for treatment with drugs with known mechanisms of action.

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Publications & Recognition
  • B cell activator PAX5 promotes lymphomagenesis through stimulation of B cell receptor signaling
  • J Clin Invest 2007 Sep; 117(9): 2602-10
  • Cozma D, Yu D, Hodawadekar S, Azvolinsky A, Grande S, Tobias JW, Metzgar MH, Paterson J, Erikson J, Marafioti T, Monroe JG, Atchison ML, Thomas-Tikhonenko A
  • View Abstract on PubMed
  • An immunoreceptor tyrosine activation motif in the mouse mammary tumor virus envelope protein plays a role in virus-induced mammary tumors
  • J Virol 2006 Sep; 80(18): 9000-8
  • Ross SR, Schmidt JW, Katz E, Cappelli L, Hultine S, Gimotty P, Monroe JG
  • View Abstract on PubMed
  • Cellular ITAM-containing proteins are oncoproteins in nonhematopoietic cells
  • Oncogene 2006 May 4; 25(19): 2748-57
  • Grande SM, Katz E, Crowley JE, Bernardini MS, Ross SR, Monroe JG
  • View Abstract on PubMed
 
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  • Harvard Medical School, Department of Pathology
  • Postdoctoral Fellow
  • 1983-1984
  • Duke University, Department of Microbiology and Immunology
  • Ph.D
  • 1979-1982
  • California State University, Northridge, Department of Cell Biology
  • M.S
  • 1977-1979
  • University of California, Los Angeles, Department of Biochemistry
  • B.S
  • 1971-1975
Publications & Recognition
  • B cell activator PAX5 promotes lymphomagenesis through stimulation of B cell receptor signaling
  • J Clin Invest 2007 Sep; 117(9): 2602-10
  • Cozma D, Yu D, Hodawadekar S, Azvolinsky A, Grande S, Tobias JW, Metzgar MH, Paterson J, Erikson J, Marafioti T, Monroe JG, Atchison ML, Thomas-Tikhonenko A
  • View Abstract on PubMed
  • An immunoreceptor tyrosine activation motif in the mouse mammary tumor virus envelope protein plays a role in virus-induced mammary tumors
  • J Virol 2006 Sep; 80(18): 9000-8
  • Ross SR, Schmidt JW, Katz E, Cappelli L, Hultine S, Gimotty P, Monroe JG
  • View Abstract on PubMed
  • Cellular ITAM-containing proteins are oncoproteins in nonhematopoietic cells
  • Oncogene 2006 May 4; 25(19): 2748-57
  • Grande SM, Katz E, Crowley JE, Bernardini MS, Ross SR, Monroe JG
  • View Abstract on PubMed
  • ITAM-mediated tonic signalling through pre-BCR and BCR complexes
  • Nat Rev Immunol 2006 Apr; 6(4): 283-94
  • Monroe JG
  • View Abstract on PubMed
  • Membrane cholesterol content accounts for developmental differences in surface B cell receptor compartmentalization and signaling
  • J Biol Chem 2005 Jul 8; 280(27): 25621-8
  • Karnell FG, Brezski RJ, King LB, Silverman MA, Monroe JG
  • View Abstract on PubMed
  • MMTV Env encodes an ITAM responsible for transformation of mammary epithelial cells in three-dimensional culture
  • J Exp Med 2005 Feb 7; 201(3): 431-9
  • Katz E, Lareef MH, Rassa JC, Grande SM, King LB, Russo J, Ross SR, Monroe JG
  • View Abstract on PubMed
  • Basal Igalpha/Igbeta signals trigger the coordinated initiation of pre-B cell antigen receptor-dependent processes
  • J Immunol 2004 Jul 15; 173(2): 1000-11
  • Fuentes-Panana EM, Bannish G, Shah N, Monroe JG
  • View Abstract on PubMed
  • Oscillation between B-lymphoid and myeloid lineages in Myc-induced hematopoietic tumors following spontaneous silencing/reactivation of the EBF/Pax5 pathway
  • Blood 2003 Mar 1; 101(5): 1950-5
  • Yu D, Allman D, Goldschmidt MH, Atchison ML, Monroe JG, Thomas-Tikhonenko A
  • View Abstract on PubMed
  • Ligand-independent signaling functions for the B lymphocyte antigen receptor and their role in positive selection during B lymphopoiesis
  • J Exp Med 2001 Dec 3; 194(11): 1583-96
  • Bannish G, Fuentes-Panana EM, Cambier JC, Pear WS, Monroe JG
  • View Abstract on PubMed
  • Role for transcription Pax5A factor in maintaining commitment to the B cell lineage by selective inhibition of granulocyte-macrophage colony-stimulating factor receptor expression
  • J Immunol 2001 May 15; 166(10): 6091-8
  • Chiang MY, Monroe JG
  • View Abstract on PubMed
  • Immunology. B cell receptor rehabilitation--pausing to reflect
  • Science 2001 Feb 23; 291(5508): 1503-5
  • King LB, Monroe JG
  • View Abstract on PubMed
  • Cutting edge: differential sequestration of plasma membrane-associated B cell antigen receptor in mature and immature B cells into glycosphingolipid-enriched domains
  • J Immunol 2001 Jan 15; 166(2): 736-40
  • Chung JB, Baumeister MA, Monroe JG
  • View Abstract on PubMed
  • BSAP/Pax5A expression blocks survival and expansion of early myeloid cells implicating its involvement in maintaining commitment to the B-lymphocyte lineage
  • Blood 1999 Dec 1; 94(11): 3621-32
  • Chiang MY, Monroe JG
  • View Abstract on PubMed
  • Antigen receptor-induced signal transduction imbalances associated with the negative selection of immature B cells
  • J Immunol 1999 Mar 1; 162(5): 2655-62
  • King LB, Norvell A, Monroe JG
  • View Abstract on PubMed
  • Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter
  • Immunity 1999 Mar; 10(3): 289-99
  • Sandel PC, Monroe JG
  • View Abstract on PubMed
  • Evidence for early B-cell activation preceding the development of Epstein-Barr virus-negative acquired immunodeficiency syndrome-related lymphoma
  • Blood 1996 Dec 15; 88(12): 4620-9
  • Przybylski GK, Goldman J, Ng VL, McGrath MS, Herndier BG, Schenkein DP, Monroe JG, Silberstein LE
  • View Abstract on PubMed
  • Role of EGR1 in regulation of stimulus-dependent CD44 transcription in B lymphocytes
  • Mol Cell Biol 1996 May; 16(5): 2283-94
  • Maltzman JS, Carman JA, Monroe JG
  • View Abstract on PubMed
  • Transcriptional regulation of the Icam-1 gene in antigen receptor- and phorbol ester-stimulated B lymphocytes: role for transcription factor EGR1
  • J Exp Med 1996 Apr 1; 183(4): 1747-59
  • Maltzman JS, Carmen JA, Monroe JG
  • View Abstract on PubMed
  • Acquisition of surface IgD fails to protect from tolerance-induction. Both surface IgM- and surface IgD-mediated signals induce apoptosis of immature murine B lymphocytes
  • J Immunol 1996 Feb 15; 156(4): 1328-32
  • Norvell A, Monroe JG
  • View Abstract on PubMed
  • Engagement of the antigen-receptor on immature murine B lymphocytes results in death by apoptosis
  • J Immunol 1995 May 1; 154(9): 4404-13
  • Norvell A, Mandik L, Monroe JG
  • View Abstract on PubMed
  • A ternary complex factor-dependent mechanism mediates induction of egr-1 through selective serum response elements following antigen receptor cross-linking in B lymphocytes
  • Mol Cell Biol 1995 Feb; 15(2): 1086-93
  • McMahon SB, Monroe JG
  • View Abstract on PubMed
  • Activation of the p21ras pathway couples antigen receptor stimulation to induction of the primary response gene egr-1 in B lymphocytes
  • J Exp Med 1995 Jan 1; 181(1): 417-22
  • McMahon SB, Monroe JG
  • View Abstract on PubMed
  • Signaling through surface IgM in tolerance-susceptible immature murine B lymphocytes. Developmentally regulated differences in transmembrane signaling in splenic B cells from adult and neonatal mice
  • J Immunol 1991 Mar 1; 146(5): 1446-54
  • Yellen AJ, Glenn W, Sukhatme VP, Cao XM, Monroe JG
  • View Abstract on PubMed
  • Methylation of an immediate-early inducible gene as a mechanism for B cell tolerance induction
  • Science 1990 Nov 9; 250(4982): 797-800
  • Seyfert VL, McMahon SB, Glenn WD, Yellen AJ, Sukhatme VP, Cao XM, Monroe JG
  • View Abstract on PubMed
  • Differential expression of a zinc finger-encoding gene in response to positive versus negative signaling through receptor immunoglobulin in murine B lymphocytes
  • Mol Cell Biol 1989 May; 9(5): 2083-8
  • Seyfert VL, Sukhatme VP, Monroe JG
  • View Abstract on PubMed
  • Isolation and characterization of a B lymphocyte mutant with altered signal transduction through its antigen receptor
  • J Exp Med 1989 Mar 1; 169(3): 1059-70
  • Monroe JG, Seyfert VL, Owen CS, Sykes N
  • View Abstract on PubMed
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Awards & Honors
  • American Association of Immunologists Distinguished Service Award - 2005
  • Dean's Award for Excellence in Graduate Training, University of Pennsylvania - 2003
  • Masters of Arts (Honorary), University of Pennsylvania - 1991
  • Aid to Cancer Research Fellow - 1983-1984

Ellen Filvaroff, Senior Scientist and Alex Avardo, Receipent of Free Medicine From the Genentech® Access to Care Foundation, on the cover of Genentech's 2006 Annual Report.