Scientist Profile

• Cambridge University, England
• Postdoctoral Fellow
• 1996-1998

• University of Washington, Seattle
• Postdoctoral Fellow
• 1995

• University of California, Berkeley, Molecular and Cell Biology
• Ph.D
• 1995

• University of Iowa, Microbiology
• B.S.
• 1986

Publications & Recognition

• Nuclear Phospho-Akt Increase Predicts Synergy of PI3K Inhibition and Doxorubicin in Breast and Ovarian Cancer
• Science Translational Medicine. 2010 Sep 8;2(48):48ra66
• Wallin JJ, Guan J, Prior WW, Edgar KA, Kassees R, Sampath D, Belvin M, Friedman LS
• View Abstract on PubMed

• Predictive Biomarkers of Sensitivity to the Phosphatidylinositol 3'Kinase Inhibitor GDC-0941 in Breast Cancer Preclinical Models
• Clinical Cancer Research 2010 May 7; doi: 10.1158/1078-0432.CCR-09-2828
• O'Brien C, Wallin J, Sampath D, Guhathakurta D, Savage H, Punnoose E, Guan J, Berry L, Prior WW, Amler LC, Belvin M, Friedman LS, Lackner MR
• View Abstract on PubMed

• RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
• Nature. 2010 Mar 18; 464(7287):431-5
• Hatzivassiliou G, Song K, Yen I, Brandhuber BJ, Anderson DJ, Alvarado R, Ludlam MJ, Stokoe D, Gloor SL, Vigers G, Morales T, Aliagas I, Liu B, Sideris S, Hoeflich KP, Jaiswal BS, Seshagiri S, Koeppen H, Belvin M, Friedman LS, Malek S
• View Abstract on PubMed

• Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors for the treatment of cancer
• J Med Chem. 2010 Feb 11; 53(3):1086-97
• Sutherlin DP, Sampath D, Berry M, Castanedo G, Chang Z, Chuckowree I, Dotson J, Folkes A, Friedman L, Goldsmith R, Heffron T, Lee L, Lesnick J, Lewis C, Mathieu S, Nonomiya J, Olivero A, Pang J, Prior WW, Salphati L, Sideris S, Tian Q, Tsui V, Wan NC, Wang S, Wiesmann C, Wong S, Zhu BY
• View Abstract on PubMed

• Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors
• Cancer Res. 2010 Feb 1; 70(3):1164-72
• Edgar KA, Wallin JJ, Berry M, Lee LB, Prior WW, Sampath D, Friedman LS, Belvin M
• View Abstract on PubMed

• Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer
• Proc Natl Acad Sci USA 2009 Oct 27; 106(43):18351-6
• Sos ML, Fischer S, Ullrich R, Peifer M, Heuckmann JM, Koker M, Heynck S, Stuckrath I, Weiss J, Fischer F, Michel K, Goel A, Regales L, Politi KA, Perera S, Getlik M, Heukamp LC, Ansen S, Zander T, Beroukhim R, Kashkar H, Shokat KM, Sellers WR, Rauh D, Orr C, Hoeflich KP, Friedman L, Wong KK, Pao W, Thomas RK
• View Abstract on PubMed

• Suppression of HER2/HER3-mediated growth of breast cancer cells with combinations of GDC-0941 PI3K inhibitor, trastuzumab, and pertuzumab
• Clin Cancer Res. 2009 Jun 15; 15(12):4147-56
• Yao E, Zhou W, Lee-Hoeflich ST, Truong T, Haverty PM, Eastham-Anderson J, Lewin-Koh N, Gunter B, Belvin M, Murray LJ, Friedman LS, Sliwkowski MX, Hoeflich KP
• View Abstract on PubMed

• Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941
• Cancer Cell. 2009 May 5; 15(5):429-40
• Junttila TT, Akita RW, Parsons K, Fields C, Lewis Phillips GD, Friedman LS, Sampath D, Sliwkowski MX
• View Abstract on PubMed

• In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models
• Clin Cancer Res. 2009 Jul 15; 15(14):4649-64
• Hoeflich KP, O'Brien C, Boyd Z, Cavet G, Guerrero S, Jung K, Januario T, Savage H, Punnoose E, Truong T, Zhou W, Berry L, Murray L, Amler L, Belvin M, Friedman LS, Lackner MR
• View Abstract on PubMed

• Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression
• Cancer Res. 2009 Apr 1; 69(7):3042-51
• Hoeflich KP, Herter S, Tien J, Wong L, Berry L, Chan J, O'Brien C, Modrusan Z, Seshagiri S, Lackner M, Stern H, Choo E, Murray L, Friedman LS, Belvin M
• View Abstract on PubMed

• Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents
• J Cell Biol. 2008 Oct 6; 183(1):101-16
• Degtyarev M, De Maziere A, Orr C, Lin J, Lee BB, Tien JY, Prior WW, van Dijk S, Wu H, Gray DC, Davis DP, Stern HM, Murray LJ, Hoeflich KP, Klumperman J, Friedman LS, Lin K
• View Abstract on PubMed

• The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer
• J Med Chem 2008 Sep 25; 51(18): 5522-32
• Folkes AJ, Ahmadi K, Alderton WK, Alix S, Saker SJ, Box G, Chuckowree IS, Clark PA, Depledge P, Eccles SA, Friedman LS, Hayes A, Hancox TC, Kugendrades A, Lensun L, Moore P, Olivero AG, Pang J, Patel S, Pergl-Wilson GH, Raynaud FL, Robson A, Saghir N, Salphati, Sohal S, Ultasch MH, Valenti M, Wallweber HJ, Wan NC, Wiesmann C, Workman P, Zhyyoloup A, Zyelebil MJ, Shuttleworth SJ
• View Abstract on PubMed

• Synthetic lethality of retinoblastoma mutant cells in the Drosophila eye by mutation of a novel peptidyl prolyl isomerase gene
• Genetics 2005 May; 170(1): 161-71
• Edgar KA, Belvin M, Parks AL, Whittaker K, Mahoney MB, Nicoll M, Park CC, Winter CG, Chen F, Lickteig K, Ahmad F, Esengil H, Lorenzi MV, Norton A, Rupnow BA, Shayesteh L, Tabios M, Young LM, Carroll PM, Kopczynski C, Plowman GD, Friedman LS, Francis-Lang HL
• View Abstract on PubMed

• Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome
• Nat Genet 2004 Mar; 36(3): 288-92
• Parks AL, Cook KR, Belvin M, Dompe NA, Fawcett R, Huppert K, Tan LR, Winter CG, Bogart KP, Deal JE, Deal-Herr ME, Grant D, Marcinko M, Miyazaki WY, Robertson S, Shaw KJ, Tabios M, Vysotskaia V, Zhao L, Andrade RS, Edgar KA, Howie E, Killpack K, Milash B, Norton A, Thao D, Whittaker K, Winner MA, Friedman L, Margolis J, Singer MA, Kopczynski C, Curtis D, Kaufman TC, Plowman GD, Duyk G, Francis-Lang HL
• View Abstract on PubMed

• Drosophila p53 is a structural and functional homolog of the tumor suppressor p53
• Cell 2000 Mar 31; 101(1): 91-101
• Ollmann M, Young LM, Di Como CJ, Karim F, Belvin M, Robertson S, Whittaker K, Demsky M, Fisher WW, Buchman A, Duyk G, Friedman L, Prives C, Kopczynski C
• View Abstract on PubMed

• Increased frequency of TP53 mutations in BRCA1 and BRCA2 ovarian tumours
• Genes Chromosomes Cancer 1999 Jun; 25(2): 91-6
• Ramus SJ, Bobrow LG, Pharoah PD, Finnigan DS, Fishman A, Altaras M, Harrington PA, Gayther SA, Ponder BA, Friedman LS
• View Abstract on PubMed

• Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2
• Mol Cell 1999 Jul; 4(1): 1-10
• Lee H, Trainer AH, Friedman LS, Thistlethwaite FC, Evans MJ, Ponder BA, Venkitaraman AR
• View Abstract on PubMed

• Thymic lymphomas in mice with a truncating mutation in Brca2
• Cancer Res 1998 Apr 1; 58(7): 1338-43
• Friedman LS, Thistlethwaite FC, Patel KJ, Yu VP, Lee H, Venkitaraman AR, Abel KJ, Carlton MB, Hunter SM, Colledge WH, Evans MJ, Ponder BA
• View Abstract on PubMed

• Involvement of Brca2 in DNA repair
• Mol Cell 1998 Feb; 1(3): 347-57
• Patel KJ, Yu VP, Lee H, Corcoran A, Thistlethwaite FC, Evans MJ, Colledge WH, Friedman LS, Ponder BA, Venkitaraman AR
• View Abstract on PubMed

• Novel inherited mutations and variable expressivity of BRCA1 alleles, including the founder mutation 185delAG in Ashkenazi Jewish families
• Am J Hum Genet 1995 Dec; 57(6): 1284-97
• Friedman LS, Szabo CI, Ostermeyer EA, Dowd P, Butler L, Park T, Lee MK, Goode EL, Rowell SE, King MC
• View Abstract on PubMed

• A collaborative survey of 80 mutations in the BRCA1 breast and ovarian cancer susceptibility gene. Implications for presymptomatic testing and screening
• JAMA 1995 Feb 15; 273(7): 535-41
• Shattuck-Eidens D, McClure M, Simard J, Labrie F, Narod S, Couch F, Hoskins K, Weber B, Castilla L, Erdos M
• View Abstract on PubMed

• Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families
• Nat Genet 1994 Dec; 8(4): 399-404
• Friedman LS, Ostermeyer EA, Szabo CI, Dowd P, Lynch ED, Rowell SE, King MC
• View Abstract on PubMed

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Awards & Honors

• 
  Hitchings-Elion Fellow, Burroughs Wellcome Fund - 1996-1998

• 
  Sigrid Juselius Foundation Visiting Scientist, Helsinki University - 1995

• 
  Susan G. Komen Breast Cancer Foundation Fellow - 1993-1995

• 
  Clare Booth Luce Fellowship, University of California, Berkeley - 1990-1991