Marcia Belvin
Senior Scientist, Translational Oncology
"Working at Genentech, you are surrounded by people who are driven by the same goal - improving patients' lives. It's a company-wide vision that motivates everyone. I feel very fortunate to have such an important goal to strive for and to work in a company with the means to achieve it."
-
My Keywords
Translational Oncology, Oncology -
My Department
Translational Oncology
I started at Genentech in the fall of 2004 after having been in the biotech industry for six years. The benefits of being at Genentech were immediately clear - working in a research-driven company with extremely smart, collaborative colleagues who all share a passion for translating science into help for cancer patients.
My Focus
Our group focuses on understanding several of the major signaling pathways that drive solid tumor growth, and using this knowledge to help determine which pathway components are the best to target, and which patients will benefit the most from inhibiting those targets. We work with compounds at various stages of development to understand the effects of those compounds in cancer cells, both as single agents and when used in combination with other drugs.
Publications & Recognition
- RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
- Nature 2010 Feb 3
- Hatzivassiliou G, Song K, Yen I, Brandhuber BJ, Anderson DJ, Alvarado R, Ludlam MJ, Stokoe D, Gloor SL, Vigers G, Morales T, Aliagas I, Liu B, Sideris S, Hoeflich KP, Jaiswal BS, Seshagiri S, Koeppen H, Belvin M, Friedman LS, Malek S
- View Abstract on PubMed
- Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors
- Cancer Res 2010 Feb 1; 70(3): 1164-72
- Edgar KA, Wallin JJ, Berry M, Lee LB, Prior WW, Sampath D, Friedman LS, Belvin M
- View Abstract on PubMed
- In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models
- Clin Cancer Res 2009 Jul 15; 15(14): 4649-64
- Hoeflich KP, O'Brien C, Boyd Z, Cavet G, Guerrero S, Jung K, Januario T, Savage H, Punnoose E, Truong T, Zhou W, Berry L, Murray L, Amler L, Belvin M, Friedman LS, Lackner MR
- View Abstract on PubMed
- Cold Spring Harbor
- Postdoctoral Fellow
- 1996-1998
- University of California Berkeley
- Ph.D
- 1990-1995
- Harvard University
- B.A.
- 1984-1988
Publications & Recognition
- RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
- Nature 2010 Feb 3
- Hatzivassiliou G, Song K, Yen I, Brandhuber BJ, Anderson DJ, Alvarado R, Ludlam MJ, Stokoe D, Gloor SL, Vigers G, Morales T, Aliagas I, Liu B, Sideris S, Hoeflich KP, Jaiswal BS, Seshagiri S, Koeppen H, Belvin M, Friedman LS, Malek S
- View Abstract on PubMed
- Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors
- Cancer Res 2010 Feb 1; 70(3): 1164-72
- Edgar KA, Wallin JJ, Berry M, Lee LB, Prior WW, Sampath D, Friedman LS, Belvin M
- View Abstract on PubMed
- In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models
- Clin Cancer Res 2009 Jul 15; 15(14): 4649-64
- Hoeflich KP, O'Brien C, Boyd Z, Cavet G, Guerrero S, Jung K, Januario T, Savage H, Punnoose E, Truong T, Zhou W, Berry L, Murray L, Amler L, Belvin M, Friedman LS, Lackner MR
- View Abstract on PubMed
- Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression
- Cancer Res 2009 Apr 1; 69(7): 3042-51
- Hoeflich KP, Herter S, Tien J, Wong L, Berry L, Chan J, O'Brien C, Modrusan Z, Seshagiri S, Lackner M, Stern H, Choo E, Murray L, Friedman LS, Belvin M
- View Abstract on PubMed
- Pharmacodynamics of 2-[4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridine-4-yl)-1H-pyrazol-1-yl]ethan-1-ol (GDC-0879), a potent and selective B-Raf kinase inhibitor: understanding relationships between systemic concentrations, phosphorylated mitogen-activated protein kinase kinase 1 inhibition, and efficacy
- J Pharmacol Exp Ther 2009 Apr; 329(1): 360-7
- Wong H, Belvin M, Herter S, Hoeflich KP, Murray LJ, Wong L, Choo EF
- View Abstract on PubMed
- Dual detection of fungal infections in Drosophila via recognition of glucans and sensing of virulence factors
- Cell 2006 Dec 29; 127(7): 1425-37
- Gottar M, Gobert V, Matskevich AA, Reichhart JM, Wang C, Butt TM, Belvin M, Hoffmann JA, Ferrandon D
- View Abstract on PubMed
- Synthetic lethality of retinoblastoma mutant cells in the Drosophila eye by mutation of a novel peptidyl prolyl isomerase gene
- Genetics 2005 May; 170(1): 161-71
- Edgar KA, Belvin M, Parks AL, Whittaker K, Mahoney MB, Nicoll M, Park CC, Winter CG, Chen F, Lickteig K, Ahmad F, Esengil H, Lorenzi MV, Norton A, Rupnow BA, Shayesteh L, Tabios M, Young LM, Carroll PM, Kopczynski C, Plowman GD, Friedman LS, Francis-Lang HL
- View Abstract on PubMed
- Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome
- Nat Genet 2004 Mar; 36(3): 288-92
- Parks AL, Cook KR, Belvin M, Dompe NA, Fawcett R, Huppert K, Tan LR, Winter CG, Bogart KP, Deal JE, Deal-Herr ME, Grant D, Marcinko M, Miyazaki WY, Robertson S, Shaw KJ, Tabios M, Vysotskaia V, Zhao L, Andrade RS, Edgar KA, Howie E, Killpack K, Milash B, Norton A, Thao D, Whittaker K, Winner MA, Friedman L, Margolis J, Singer MA, Kopczynski C, Curtis D, Kaufman TC, Plowman GD, Duyk G, Francis-Lang HL
- View Abstract on PubMed
- Dual activation of the Drosophila toll pathway by two pattern recognition receptors
- Science 2003 Dec 19; 302(5653): 2126-30
- Gobert V, Gottar M, Matskevich AA, Rutschmann S, Royet J, Belvin M, Hoffmann JA, Ferrandon D
- View Abstract on PubMed
- DmMyD88 controls dorsoventral patterning of the Drosophila embryo
- EMBO Rep 2003 Jan; 4(1): 64-9
- Kambris Z, Bilak H, D'Alessandro R, Belvin M, Imler JL, Capovilla M
- View Abstract on PubMed
- A serpin mutant links Toll activation to melanization in the host defence of Drosophila
- EMBO J 2002 Dec 2; 21(23): 6330-7
- Ligoxygakis P, Pelte N, Ji C, Leclerc V, Duvic B, Belvin M, Jiang H, Hoffmann JA, Reichhart JM
- View Abstract on PubMed
- The Drosophila immune defense against gram-negative infection requires the death protein dFADD
- Immunity 2002 Nov; 17(5): 575-81
- Naitza S, Rosse C, Kappler C, Georgel P, Belvin M, Gubb D, Camonis J, Hoffmann JA, Reichhart JM
- View Abstract on PubMed
- The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein
- Nature 2002 Apr 11; 416(6881): 640-4
- Gottar M, Gobert V, Michel T, Belvin M, Duyk G, Hoffmann JA, Ferrandon D, Royet J
- View Abstract on PubMed
- A genome-wide analysis of immune responses in Drosophila
- Proc Natl Acad Sci U S A 2001 Dec 18; 98(26): 15119-24
- Irving P, Troxler L, Heuer TS, Belvin M, Kopczynski C, Reichhart JM, Hoffmann JA, Hetru C
- View Abstract on PubMed
- fusilli, an essential gene with a maternal role in Drosophila embryonic dorsal-ventral patterning
- Dev Biol 2001 Jan 1; 229(1): 44-54
- Wakabayashi-Ito N, Belvin MP, Bluestein DA, Anderson KV
- View Abstract on PubMed
- Drosophila p53 is a structural and functional homolog of the tumor suppressor p53
- Cell 2000 Mar 31; 101(1): 91-101
- Ollmann M, Young LM, Di Como CJ, Karim F, Belvin M, Robertson S, Whittaker K, Demsky M, Fisher WW, Buchman A, Duyk G, Friedman L, Prives C, Kopczynski C
- View Abstract on PubMed
- The Drosophila dCREB2 gene affects the circadian clock
- Neuron 1999 Apr; 22(4): 777-87
- Belvin MP, Zhou H, Yin JC
- View Abstract on PubMed
- Drosophila learning and memory: recent progress and new approaches
- Bioessays 1997 Dec; 19(12): 1083-9
- Belvin MP, Yin JC
- View Abstract on PubMed
- A conserved signaling pathway: the Drosophila toll-dorsal pathway
- Annu Rev Cell Dev Biol 1996; 12: 393-416
- Belvin MP, Anderson KV
- View Abstract on PubMed
- Cactus protein degradation mediates Drosophila dorsal-ventral signaling
- Genes Dev 1995 Apr 1; 9(7): 783-93
- Belvin MP, Jin Y, Anderson KV
- View Abstract on PubMed
- Heterogeneous expression of the product of the retinoblastoma susceptibility gene in primary human leukemia cells
- Oncogene 1991 Aug; 6(8): 1343-6
- Furukawa Y, DeCaprio JA, Belvin M, Griffin JD
- View Abstract on PubMed
- Anti-MY9-blocked-ricin: an immunotoxin for selective targeting of acute myeloid leukemia cells
- Blood 1991 Jun 1; 77(11): 2404-12
- Roy DC, Griffin JD, Belvin M, Blattler WA, Lambert JM, Ritz J
- View Abstract on PubMed
- Regulation of leukocyte adhesion molecule-1 (TQ1, Leu-8) expression and shedding by normal and malignant cells
- Leukemia 1991 Apr; 5(4): 300-8
- Spertini O, Freedman AS, Belvin MP, Penta AC, Griffin JD, Tedder TF
- View Abstract on PubMed
- Granulocyte-macrophage colony-stimulating factor and other cytokines regulate surface expression of the leukocyte adhesion molecule-1 on human neutrophils, monocytes, and their precursors
- J Immunol 1990 Jul 15; 145(2): 576-84
- Griffin JD, Spertini O, Ernst TJ, Belvin MP, Levine HB, Kanakura Y, Tedder TF
- View Abstract on PubMed
