Menno Van Lookeren Campagne
Senior Scientist, Immunology-
My Keywords
Immunology -
My Department
Immunology
I joined Genentech as a postdoctoral fellow in 1997 and in 1999 as a scientist in the Immunology Department. I was extremely motivated to join Genentech since it is one of the few places where high quality discovery research and drug development are directly connected.
During my years at the company, I have experienced first hand the immense satisfaction of discovering a new receptor-ligand interaction and developing this molecular entity into a novel drug. In the process, I learned to appreciate the many other aspects that are unique to Genentech culture, including the collaborative and creative spirit among the scientists. I'm proud of being a part of this culture and especially proud of contributing to the highest goal one can think of: finding a cure for a devastating disease.
My Focus
The research projects in my lab are aimed at understanding the role of macrophages, immune cells whose primary function is to defend the host against pathogens, in controlling chronic inflammatory diseases. Through functional screening of macrophage-specific cell surface molecules, we identified a macrophage complement receptor, CRIg, which is required for clearance of pathogens in the circulation, thus preventing systemic bacterial infection. In addition to its function as a phagocytic receptor, the extracellular domain CRIg (Complement Receptor of the Immunoglobulin superfamily) inhibits complement activation and inflammation in experimental models of arthritis.
Currently a potent complement inhibitor is being developed for treatment of Age-Related Macular Degeneration (AMD), a blinding disease caused by neovascularization in the retina and degeneration of photoreceptors. Next to complement, my lab is validating additional inflammatory pathways as therapeutic targets in AMD.
Publications & Recognition
- Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1
- J Exp Med 2010 Jan 18; 207(1): 7-16, S1-5
- Xi H, Katschke KJ Jr, Helmy KY, Wark PA, Kljavin N, Clark H, Eastham-Anderson J, Shek T, Roose-Girma M, Ghilardi N, van Lookeren Campagne M
- View Abstract on PubMed
- Improving therapeutic efficacy of a complement receptor by structure-based affinity maturation
- J Biol Chem 2009 Dec 18; 284(51): 35605-11
- Li B, Xi H, Diehl L, Lee WP, Sturgeon L, Chinn J, Deforge L, Kelley RF, Wiesmann C, van Lookeren Campagne M, Sidhu SS
- View Abstract on PubMed
- Structural and functional analysis of a C3b-specific antibody that selectively inhibits the alternative pathway of complement
- J Biol Chem 2009 Apr 17; 284(16): 10473-9
- Katschke KJ Jr, Stawicki S, Yin J, Steffek M, Xi H, Sturgeon L, Hass PE, Loyet KM, Deforge L, Wu Y, van Lookeren Campagne M, Wiesmann C
- View Abstract on PubMed
- State University of Utrecht, Netherlands, Rudolf Magnus Institute of Pharmacology
- Ph.D
- 1987-1991
- State University of Utrecht, Netherlands
- Masters Degree
- 1979-1987
Publications & Recognition
- Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1
- J Exp Med 2010 Jan 18; 207(1): 7-16, S1-5
- Xi H, Katschke KJ Jr, Helmy KY, Wark PA, Kljavin N, Clark H, Eastham-Anderson J, Shek T, Roose-Girma M, Ghilardi N, van Lookeren Campagne M
- View Abstract on PubMed
- Improving therapeutic efficacy of a complement receptor by structure-based affinity maturation
- J Biol Chem 2009 Dec 18; 284(51): 35605-11
- Li B, Xi H, Diehl L, Lee WP, Sturgeon L, Chinn J, Deforge L, Kelley RF, Wiesmann C, van Lookeren Campagne M, Sidhu SS
- View Abstract on PubMed
- Structural and functional analysis of a C3b-specific antibody that selectively inhibits the alternative pathway of complement
- J Biol Chem 2009 Apr 17; 284(16): 10473-9
- Katschke KJ Jr, Stawicki S, Yin J, Steffek M, Xi H, Sturgeon L, Hass PE, Loyet KM, Deforge L, Wu Y, van Lookeren Campagne M, Wiesmann C
- View Abstract on PubMed
- Complement receptor of the Ig superfamily enhances complement-mediated phagocytosis in a subpopulation of tissue resident macrophages
- J Immunol 2008 Dec 1; 181(11): 7902-8
- Gorgani NN, He JQ, Katschke KJ Jr, Helmy KY, Xi H, Steffek M, Hass PE, van Lookeren Campagne M
- View Abstract on PubMed
- Deficiency of DAF and Crry on murine platelets leads to complement-dependent clearance via the macrophage phagocytic receptor CRIg
- Blood 2008 Aug 15; 112(4): 1109-19
- Kim DD, Miwa T, Kimura Y, Schwendener RA, van Lookeren Campagne M, Song WC
- View Abstract on PubMed
- Macrophage complement receptors and pathogen clearance
- Cell Microbiol 2007 Sep; 9(9): 2095-102.
- van Lookeren Campagne M, Wiesmann C, Brown EJ
- View Abstract on PubMed
- A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis
- J Exp Med 2007 Jun 11; 204(6): 1319-25
- Katschke KJ, Helmy KY, Steffek M, Xi H, Yin J, Lee WP, Gribling P, Barck KH, Carano RA, Taylor RE, Rangell L, Diehl L, Hass PE, Wiesmann C, van Lookeren Campagne M
- View Abstract on PubMed
- Structure of C3b in complex with CRIg gives insights into regulation of complement activation
- Nature 2006 Nov 9; 444(7116): 217-20
- Wiesmann C, Katschke KJ, Yin J, Helmy KY, Steffek M, Fairbrother WJ, McCallum SA, Embuscado L, DeForge L, Hass PE, van Lookeren Campagne M
- View Abstract on PubMed
- CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens
- Cell 2006 Mar 10; 124(5): 915-27
- Helmy KY, Katschke KJ, Gorgani NN, Kljavin NM, Elliott JM, Diehl L, Scales SJ, Ghilardi N, van Lookeren Campagne M
- View Abstract on PubMed
- Increased binding activity at an antioxidant-responsive element in the metallothionein-1 promoter and rapid induction of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion
- J Neurosci 2000 Jul 15; 20(14): 5200-7.
- Campagne MV, Thibodeaux H, van Bruggen N, Cairns B, Lowe DG
- View Abstract on PubMed
- Evidence for a protective role of metallothionein-1 in focal cerebral ischemia
- Proc Natl Acad Sci U S A 1999 Oct 26; 96(22): 12870-5
- Van Lookeren Campagne M, Thibodeaux H, van Bruggen N, Cairns B, Gerlai R, Palmer JT, Williams SP, Lowe DG
- View Abstract on PubMed
