Paul Polakis
Director, Staff Scientist: Discovery Oncology-
My Keywords
Discovery Oncology, Oncology -
My Department
Discovery Oncology
I worked at Genentech as a postdoc from 1987-1989 and then returned as Senior Scientist in 1999. Since returning in 1999, I have headed the Tumor Antigen Project in an effort to identify tumor cell markers that will serve as targets for therapeutic antibodies.
My Focus
My current projects include the identification of antigens that are expressed on the surface of human cancer cells. The overall goal of this project is to raise antibodies to these antigens that will ultimately serve as therapeutics in the treatment of cancer.
As an extension of this project, my lab has been analyzing gene expression patterns that result from the treatment of human tumors and cell lines with standard care chemotherapeutic agents. We also work on the Wnt signaling pathway, in which defects are common in human colorectal cancer.
Publications & Recognition
- The Soluble Wnt Receptor Frizzled8CRD-hFc Inhibits the Growth of Teratocarcinomas In vivo
- Cancer Res 2007 Jun 1; 67(11): 5371-9
- Dealmeida VI, Miao L, Ernst JA, Koeppen H, Polakis P, Rubinfeld B
- View Abstract on PubMed
- Armed Antibodies Targeting the Mucin Repeats of the Ovarian Cancer Antigen, MUC16, Are Highly Efficacious in Animal Tumor Models
- Cancer Res 2007 May 15; 67(10): 4924-32
- Chen Y, Clark S, Wong T, Chen Y, Chen Y, Dennis MS, Luis E, Zhong F, Bheddah S, Koeppen H, Gogineni A, Polakis P
- View Abstract on PubMed
- The many ways of Wnt in cancer
- Curr Opin Genet Dev 2007 Feb; 17(1): 45-51
- Polakis P
- View Abstract on PubMed
- Michigan State University, Department of Biochemistry
- Ph.D.
- 1980-1984
- Michigan State University, Department of Biochemistry
- Graduate Research Assistant
- 1980-1984
- Michigan State University, Department of Biology
- B.S.
- 1973-1977
Publications & Recognition
- The Soluble Wnt Receptor Frizzled8CRD-hFc Inhibits the Growth of Teratocarcinomas In vivo
- Cancer Res 2007 Jun 1; 67(11): 5371-9
- Dealmeida VI, Miao L, Ernst JA, Koeppen H, Polakis P, Rubinfeld B
- View Abstract on PubMed
- Armed Antibodies Targeting the Mucin Repeats of the Ovarian Cancer Antigen, MUC16, Are Highly Efficacious in Animal Tumor Models
- Cancer Res 2007 May 15; 67(10): 4924-32
- Chen Y, Clark S, Wong T, Chen Y, Chen Y, Dennis MS, Luis E, Zhong F, Bheddah S, Koeppen H, Gogineni A, Polakis P
- View Abstract on PubMed
- The many ways of Wnt in cancer
- Curr Opin Genet Dev 2007 Feb; 17(1): 45-51
- Polakis P
- View Abstract on PubMed
- Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer
- Oncogene 2006 Jul 20; 25(31): 4361-9
- Shulewitz M, Soloviev I, Wu T, Koeppen H, Polakis P, Sakanaka C
- View Abstract on PubMed
- Identification and immunotherapeutic targeting of antigens induced by chemotherapy
- Nat Biotechnol 2006 Feb; 24(2): 205-9
- Rubinfeld B, Upadhyay A, Clark SL, Fong SE, Smith V, Koeppen H, Ross S, Polakis P
- View Abstract on PubMed
- Arming antibodies for cancer therapy
- Curr Opin Pharmacol 2005 Aug; 5(4): 382-7
- Polakis P
- View Abstract on PubMed
- EphB2 as a therapeutic antibody drug target for the treatment of colorectal cancer
- Cancer Res 2004 Feb 1; 64(3): 781-8
- Mao W, Luis E, Ross S, Silva J, Tan C, Crowley C, Chui C, Franz G, Senter P, Koeppen H, Polakis P
- View Abstract on PubMed
- Stabilization of beta-catenin by genetic defects in melanoma cell lines
- Science 1997 Mar 21; 275(5307): 1790-2
- Rubinfeld B, Robbins P, El-Gamil M, Albert I, Porfiri E, Polakis P
- View Abstract on PubMed
- Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
- Science 1996 May 17; 272(5264): 1023-6
- Rubinfeld B, Albert I, Porfiri E, Fiol C, Munemitsu S, Polakis P
- View Abstract on PubMed
- Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
- Proc Natl Acad Sci U S A 1995 Mar 28; 92(7): 3046-50
- Munemitsu S, Albert I, Souza B, Rubinfeld B, Polakis P
- View Abstract on PubMed
- Association of the APC gene product with beta-catenin
- Science 1993 Dec 10; 262(5140): 1731-4
- Rubinfeld B, Souza B, Albert I, Muller O, Chamberlain SH, Masiarz FR, Munemitsu S, Polakis P
- View Abstract on PubMed
- Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1
- Cell 1991 Jun 14; 65(6): 1033-42
- Rubinfeld B, Munemitsu S, Clark R, Conroy L, Watt K, Crosier WJ, McCormick F, Polakis P
- View Abstract on PubMed
