Scientist Profile

• University of California, San Francisco, Graduate Group in Biophysics
• Ph.D.
• 1998

• Swarthmore College, Department of Chemistry
• B.A.
• 1992

Publications & Recognition

• Stabilizing receptor quiescence with synthetic antibodies enables therapeutic targeting of individual Notch receptors
• Nature 2010
• Wu Y, Cain-Hom C, Choi L, de Leon GP, Chen Y, Wu X, Ridgway J, Schahin-Reed D, Dow GJ, Hagenbeek TJ, Stawicki S, Watts RJ, Zhang J, Choy R, Howard P, Kadyk L, Yan M, Callahan CA, Hymowitz SG, Siebel CW

• The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling
• Nat Struct Mol Biol 2009 Jul; 16(7): 691-7
• Bosanac I, Maun HR, Scales SJ, Wen X, Lingel A, Bazan JF, de Sauvage FJ, Hymowitz SG, Lazarus RA
• View Abstract on PubMed

• Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies
• Cell 2008 Aug 22; 134(4): 668-78
• Newton K, Matsumoto ML, Wertz IE, Kirkpatrick DS, Lill JR, Tan J, Dugger D, Gordon N, Sidhu SS, Fellouse FA, Komuves L, French DM, Ferrando RE, Lam C, Compaan D, Yu C, Bosanac I, Hymowitz SG, Kelley RF, Dixit VM
• View Abstract on PubMed

• Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5
• Cell Death Differ 2008 Apr; 15(4): 751-61
• Adams C, Totpal K, Lawrence D, Marsters S, Pitti R, Yee S, Ross S, Deforge L, Koeppen S, Sagolla M, Compaan D, Lowman H, Hymowitz S, Ashkenazi A
• View Abstract on PubMed

• In vivo OX40L blockade inhibits TSLP-driven atopic inflammation
• J Clin Invest 2007 Dec; 117(12): 3868-78
• Seshasayee D, Lee WP, Zhou M, Shu J, Suto E, Zhang J, Diehl J, Austin C, Meng YG, Tan M, Bullens SL, Seeber S, Fuentes ME, Labrijn AF, Graus YM, Miller LA, Schelegle ES, Hyde DM, Wu LC, Hymowitz SG, Martin F
• View Abstract on PubMed

• The mitotic regulator Survivin binds as a monomer to its functional interactor Borealin
• J Biol Chem 2007 Nov 30; 282(48): 35018-23
• Bourhis E, Hymowitz SG, Cochran AG
• View Abstract on PubMed

• Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL
• Nat Med 2007 Sep; 13(9): 1070-7
• Wagner KM, Punnoose EA, Januario T, Lawrence DA, Pitti RM, Lancaster K, Lee D, von Goetz M, Yee SF, Totpal K, Huw L, Katta V, Cavet G, Hymowitz SG, Amler L, Ashkenazi A
• View Abstract on PubMed

• The crystal structure of the costimulatory OX40-OX40L complex
• Structure 2006 Aug; 14(8): 1321-30
• Compaan DM, Hymowitz SG
• View Abstract on PubMed

• Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells
• Blood 2006 Nov 1; 108(9): 3103-11
• Lee CV, Hymowitz SG, Wallweber HJ, Gordon NC, Billeci KL, Tsai SP, Compaan DM, Yin J, Gong Q, Kelley RF, DeForge LE, Martin F, Starovasnik MA, Fuh G
• View Abstract on PubMed

• Attenuating lymphocyte activity: the crystal structure of the BTLA-HVEM complex
• J Biol Chem 2005 Nov 25; 280(47): 39553-61
• Compaan DM, Gonzalez LC, Tom I, Loyet KM, Eaton D, Hymowitz SG
• View Abstract on PubMed

• Molecular recognition by a binary code
• J Mol Biol 2005 May 20; 348(5): 1153-62
• Fellouse FA, Li B, Compaan DM, Peden AA, Hymowitz SG, Sidhu SS
• View Abstract on PubMed

• Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding
• J Biol Chem 2005 Feb 25; 280(8): 7218-27
• Hymowitz SG, Patel DR, Wallweber HJ, Runyon S, Yan M, Yin J, Shriver SK, Gordon NC, Pan B, Skelton NJ, Kelley RF, Starovasnik MA
• View Abstract on PubMed

• The crystal structures of EDA-A1 and EDA-A2: splice variants with distinct receptor specificity
• Structure (Camb) 2003 Dec; 11(12): 1513-20
• Hymowitz SG, Compaan DM, Yan M, Wallweber HJ, Dixit VM, Starovasnik MA, de Vos AM
• View Abstract on PubMed

• BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site
• Biochemistry 2003 May 27; 42(20): 5977-83
• Gordon NC, Pan B, Hymowitz SG, Yin J, Kelley RF, Cochran AG, Yan M, Dixit VM, Fairbrother WJ, Starovasnik MA
• View Abstract on PubMed

• IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding
• EMBO J 2001 Oct 1; 20(19): 5332-41
• Hymowitz SG, Filvaroff EH, Yin J, Lee J, Cai L, Risser P, Maruoka M, Mao W, Foster J, Kelley RF, Pan G, Gurney AL, de Vos AM, Starovasnik MA
• View Abstract on PubMed

• Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors
• Science 2000 Oct 20; 290(5491): 523-7
• Yan M, Wang LC, Hymowitz SG, Schilbach S, Lee J, Goddard A, de Vos AM, Gao WQ, Dixit VM
• View Abstract on PubMed

• A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL
• Biochemistry 2000 Feb 1; 39(4): 633-40
• Hymowitz SG, O'Connell MP, Ultsch MH, Hurst A, Totpal K, Ashkenazi A, de Vos AM, Kelley RF
• View Abstract on PubMed

• Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5
• Mol Cell 1999 Oct; 4(4): 563-71
• Hymowitz SG, Christinger HW, Fuh G, Ultsch M, O'Connell M, Kelley RF, Ashkenazi A, de Vos AM
• View Abstract on PubMed

• The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity
• Nat Struct Biol 1997 Dec; 4(12): 1003-9
• Gillmor SA, Villasenor A, Fletterick R, Sigal E, Browner MF
• View Abstract on PubMed

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Awards & Honors

• 
  Clemens Prize for Outstanding Thesis in Biophysics, University of California, San Francisco--1998

• 
  Chancellor's Dissertation Year Fellowship, University of California, San Francisco--1997-1998

• 
  National Science Foundation Pre-doctoral Fellowship--1992-1995