Focus on Neuroscience
The treatment of most neurological and psychiatric disorders remains a huge unmet need. Our Neuroscience Research and Drug Discovery program is aimed at discovering and developing breakthrough medicines for patients with major diseases of the nervous system, such as Alzheimer's diseases. Right now we're focused on several neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, Glaucoma, and Amyotrophic Lateral Sclerosis (Lou Gehrig's disease).
By using a multidisciplinary approach and a wide range of technologies, we hope to tackle the fundamental mechanisms underlying the biology and the diseases of the nervous system, and to translate these discoveries into innovative therapies for neurological disorders.
Recent Accomplishments
-
Publication: J Cell Biol 2011
ADLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity Read the Article -
Publication: Sci Transl Med 2011
A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-β Production in Vivo Read the Article -
Publication: Sci Transl Med 2011
Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target Read the Article
Pipeline
Genentech's Research and Early Development pipeline has over 25 new molecular entities in clinical development.
