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phases
Genentech's development pipeline continues to grow, now numbering approximately 20 projects in three therapeutic focus areas, as well as an additional category for projects outside of these focus areas. More than half the projects result from our industry-leading expertise in monoclonal antibodies. The pipeline is also balanced between breakthrough innovations and new indications for existing, well-understood products that may fight more than one disease or more than one form of a disease.

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Oncology
In 2001 Genentech realized more than $1 billion in revenues from marketed oncology products, and we are focused on becoming the industry leader in cancer therapies. Nine projects in our pipeline are aimed at various cancers, including breast, colon, lung and pancreatic, plus non-Hodgkin’s lymphoma, other hematologic malignancies and solid tumor cancers.

Cardiovascular Disease
Genentech’s pipeline has one potential product and one potential new indication for an already marketed product in the cardiovascular category. From our established position in the thrombolytic field, we are branching out to address such significant disease conditions as acute coronary syndrome.

Immunological Disease
Genentech’s rapidly growing expertise in immunology is represented in all three clinical trial phases, with projects targeting disease states affecting circulation, respiration, joints, the skin and transplant rejection. Two of the most advanced projects in our pipeline, Xolair for adult allergic asthma and Xanelim for moderate-to-severe psoriasis, are aimed at immunological conditions.

Other Unmet Needs
Genentech considers other interesting projects that fall outside these three therapeutic focus areas, provided they utilize the company’s significant expertise and address medical needs in areas where few effective therapies exist. Two such projects are moving through the development pipeline, including a potential new indication for use of Nutropin Depot in adults with growth hormone deficiency. The product is already approved and marketed for use with children who are deficient in growth hormone.

Anti-CD40 developed with Seattle Genetics; Xanelim Anti-CD11a Antibody developed with Xoma Ltd.; LDP-02 Antibody developed with Millennium Pharmaceuticals, Inc.; Herceptin adjuvant studies in early-stage breast cancer being conducted with F. Hoffmann-La Roche and U.S. National Cooperative Groups; Nutropin Depot developed with Alkermes, Inc.; Rituxan Antibody developed with IDEC Pharmaceuticals Corporation in the United States; Tarceva developed with OSI Pharmaceuticals, Inc. and Roche; Xolair Anti-IgE Antibody developed with Novartis Pharmaceuticals Corporation and Tanox, Inc.

(1) Preparing for Phase 2 clinical trials 2 clinical trials.
(2) Preparing for Phase 3 clinical trials

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