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GAAP vs. Non-GAAP Q1 2007

GENENTECH, INC.
CONSOLIDATED STATEMENTS OF INCOME
(In millions, except per share amounts)
(Unaudited)

Three Months
Ended March 31,

2007   2006

Revenues:
  Product sales $   2,329   $    1,644
  Royalties 419   286
  Contract revenue 95   56
Total operating revenues
2,843
 
1,986
       
Costs and expenses:
  Cost of sales (includes employee stock-based compensation expense: three months—2007—$16; 2006—$0) 392   262
  Research and development (includes employee stock-based compensation expense: three months—2007—$38; 2006—$33) 610   374
  Marketing, general and administrative (includes employee stock-based compensation expense: three months—2007—$46; 2006—$41) 491   441
  Collaboration profit sharing 252   226
  Recurring charges related to redemption 26   26
  Special items: litigation-related 13   13
Total costs and expenses
1,784
 
1,342
       
Operating income 1,059   644
       
Other income (expense):
  Interest and other income, net(1) 74   53
  Interest expense (18)   (19)
Total other income, net
56
 
34
       
Income before taxes 1,115   678
Income tax provision 409   257
Net income
$     706
 
$     421
       
Earnings per share:
  Basic $     0.67   $     0.40
  Diluted $     0.66   $     0.39
       
Weighted average shares used to compute earnings per share:
  Basic 1,053   1,054
  Diluted 1,071   1,075

(1) "Interest and other income, net" includes interest income, net realized gains from the sale of certain biotechnology equity securities and write-downs for other-than-temporary impairments in the fair value of certain biotechnology debt and equity securities.

GENENTECH, INC.
RECONCILIATION OF GAAP to NON-GAAP NET INCOME
(In millions, except per share amounts)
(Unaudited)

Three Months
Ended March 31,

2007   2006

GAAP net income $     706   $     421
       
Employee stock-based compensation expense under FAS 123R(1) included in the following operating expenses:
  Cost of sales 16   -
  Research and development 38   33
  Marketing, general and administrative 46   41
Recurring charges related to redemption(2) 26   26
Special items: litigation-related(3) 13   13
Income tax effect(4) (53)   (43)
Non-GAAP net income
$     792
 
$     491
       
Non-GAAP earnings per share:
  Diluted $     0.74   $     0.46
       
Non-GAAP weighted average shares used to compute earnings per share(5):
  Diluted 1,071   1,076

(1) Represents employee stock-based compensation expense associated with FAS 123R. No employee stock-based compensation expense was recognized in GAAP-reported cost of sales in any period ending prior to January 1, 2007.

(2) Represents the amortization of intangible assets related to the 1999 redemption of Genentech's common stock by Roche Holdings, Inc.

(3) Includes accrued interest and bond costs in the first quarters of 2007 and 2006 related to the City of Hope trial judgment.

(4) Reflects the income tax effects of excluding employee stock-based compensation expense under FAS 123R, recurring charges related to the redemption of our common stock, and litigation-related special items.

(5) Weighted average shares used to compute non-GAAP diluted earnings per share were computed exclusive of the methodology used to determine dilutive securities under FAS 123R.

2007 Reconciliation of GAAP and Non-GAAP EPS Estimates
Our 2007 non-GAAP EPS estimate does not include the effects of: (i) recurring amortization charges related to the 1999 redemption of our common stock by Roche Holdings, Inc., which are estimated to be approximately $104 million on a pretax basis in 2007, (ii) litigation-related special items for accrued interest and associated bond costs on the City of Hope judgment which are currently estimated to be approximately $54 million on a pretax basis in 2007, (iii) income tax effect of $63 million on recurring charges related to the redemption of our common stock and litigation-related special items, (iv) employee stock-based compensation expense, which we expect the net of tax diluted EPS impact to be in the range of $0.23 to $0.25 per share for 2007, and (v) any in-process R&D charge and amortization of intangible assets that would result if we acquire Tanox, Inc. Our 2007 GAAP EPS would include the items listed above as well as any other potential special charges related to existing or future litigation or its resolution, or changes in accounting principles, all of which may be significant. Note that our cumulative effect of a change in accounting principle related to sabbatical leave associated with our adoption of Emerging Issues Task Force Issue No. 06-2 on January 1, 2007, which was $26 million, net of tax, was recognized as an adjustment to retained earnings and not expensed as previously communicated.

The statements regarding the amounts relating to the 1999 Roche redemption of our common stock, litigation-related special items and employee stock-based compensation expense are forward-looking and such statements are predictions and involve risks and uncertainties such that actual results may differ materially. The amounts identified above could be affected by a number of factors, including a re-valuation of certain intangible assets, greater than expected litigation-related costs, the number of options granted to employees, our stock price and certain valuation assumptions concerning our stock. We disclaim, and do not undertake, any obligation to update or revise any of these forward-looking statements.

GENENTECH, INC.
SELECTED CONSOLIDATED FINANCIAL DATA
(In millions)
(Unaudited)
March 31,
2007
  December 31,
2006

Selected consolidated balance sheet data:
Cash, cash equivalents and short-term investments $        2,903   $        2,493
Accounts receivable - product sales, net 1,077   965
Accounts receivable - royalties, net 481   453
Accounts receivable - other, net 134   248
Inventories 1,297   1,178
Long-term marketable debt and equity securities 1,889   1,832
Property, plant and equipment, net 4,353   4,173
Goodwill 1,315   1,315
Other intangible assets 449   476
Other long-term assets 1,397   1,342
Total assets 15,688   14,842
Total current liabilities(1) 2,078   2,010
Long-term debt(2) 2,267   2,204
Total liabilities 5,540   5,364
Total stockholders' equity 10,148   9,478
       
       
  Three Months
Ended March 31,

2007   2006

Selected consolidated cash flow data:
Capital expenditures(2) $          209   $           253
       
Total GAAP(3) depreciation and amortization expense 106   96
  Less: redemption related amortization expense(4) (26)   (26)
Non-GAAP depreciation and amortization expense
$            80
 
$           70

(1) Certain reclassifications have been made at December 31, 2006 to conform to the March 31, 2007 presentation.

(2) Capital expenditures exclude approximately $57 million at March 31, 2007 and $27 million at March 31, 2006 in capitalized costs related to our accounting for construction projects of which we are considered to be the owner during the construction period. We have recognized related amounts as a construction financing obligation in long-term debt. The balances in long-term debt related to the construction financing obligation are $276 million at March 31, 2007 and $216 million at December 31, 2006.

(3) Reflects operating results in accordance with U.S. generally accepted accounting principles (or "GAAP").

(4) Represents the amortization of intangible assets related to the 1999 redemption of Genentech's common stock by Roche Holdings, Inc.