Description Lebrikizumab is a humanized monoclonal antibody that is designed to bind specifically to IL-13 and is currently in development for asthma. Anti-IL13 has been demonstrated to bind to human IL-13 with high affinity and neutralizes the functional activities of human IL-13. Preclinical studies suggest that IL-13 is a key mediator of asthma responses, including airway inflammation, obstruction and hyper-reactivity.

Development Status Phase II clinical trials evaluating lebrikizumab for asthma are ongoing.

Additional Information on Clinical Trials For inquiries about our clinical trials, please submit a request through our information request form or call (888) 662-6728.

National Institutes of Health Website: www.clinicaltrials.gov

February 2010