The Protein Engineering Department combines biological, structural, chemical, and combinatorial approaches to explore protein functions and molecular interactions. Our goal is to advance novel therapies and to maintain scientific innovation and excellence.

Specific achievements include:

• Improving existing proteins and enzymes to make them more effective — with higher affinity, longer lasting effects and/or greater selectivity
• Determining three-dimensional structures of proteins and protein complexes
• Finding new molecules with biological activity and exploring their potential as therapeutic agents or drug targets
• Inventing new protein/peptide technologies
• Applying chemical approaches to problems in drug discovery and biology

Crystallographers in the Protein Engineering Department determined the molecular details of the Tarceva/EGFr interaction. Information like this helps researchers design improved anti-cancer medicines with fewer side effects than traditional chemotherapeutic agents.

Recruitment We are often looking for research assistants and associates, eager and motivated people with an M.S. or B.S. degree who want to develop their skills and careers by doing hands-on science. We regularly hire postdoctoral fellows — people with recent Ph.D. degrees who want to prepare for careers as independent scientists in academia or industry.