Skip to Content for Eric Brown Menu for Eric Brown About Us Menu Research Menu Development Menu Medicines Menu Investors Menu Media Menu Careers Menu
Banner Image

Eric Brown

Eric Brown
Eric Brown Senior Director: Microbial Pathogenesis

Mentor Profile | Top Scientific Papers

Top Scientific Papers

  • N'diaye EN, Hanyaloglu AC, Kajihara KK, Puthenveedu MA, Wu P, von Zastrow M, Brown EJ. The ubiquitin-like protein PLIC-2 is a negative regulator of G protein coupled receptor endocytosis. Mol Biol Cell 2008 Mar; 19(3): 1252-12602. View Abstract on PubMed

  • Koo IC, Ohol YM, Wu P, Morisaki JH, Cox JS, Brown EJ. Role for lysosomal enzyme b-hexosaminidase in the control of mycobacteria infection. Proc Natl Acad Sci USA 2008 Jan 15; 105(2): 710-5. View Abstract on PubMed

  • McLaughlin B, Chon JS, Macgurn JA, Carlsson F, Cheng TL, Cox JS, Brown EJ. A Mycobacterium ESX-1-Secreted Virulence Factor with Unique Requirements for Export. PLoS Pathog 2007 Aug 3; 3(8): e105. View Abstract on PubMed

  • Champion PA, Stanley SA, Champion MM, Brown EJ, Cox JS. C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis. Science 2006 Sep 15; 313(5793): 1632-6. View Abstract on PubMed

  • Stamm LM, Pak MA, Morisaki JH, Snapper SB, Rottner K, Lommel S, Brown EJ. Role of the WASP family proteins for Mycobacterium marinum actin tail formation. Proc Natl Acad Sci U S A 2005 Oct 11; 102(41): 14837-42. View Abstract on PubMed

  • Gao LY, Guo S, McLaughlin B, Morisaki H, Engel JN, Brown EJ. A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion. Mol Microbiol 2004 Sep; 53(6): 1677-93. View Abstract on PubMed

  • N'Diaye EN, Brown EJ. The ubiquitin-related protein PLIC-1 regulates heterotrimeric G protein function through association with Gbetagamma. J Cell Biol 2003 Dec 8; 163(5): 1157-65. View Abstract on PubMed

  • Chen H, Mocsai A, Zhang H, Ding RX, Morisaki JH, White M, Rothfork JM, Heiser P, Colucci-Guyon E, Lowell CA, Gresham HD, Allen PM, Brown EJ. Role for plastin in host defense distinguishes integrin signaling from cell adhesion and spreading. Immunity 2003 Jul; 19(1): 95-104. View Abstract on PubMed

  • Rebres RA, Vaz LE, Green JM, Brown EJ. Normal ligand binding and signaling by CD47 (integrin-associated protein) requires a long range disulfide bond between the extracellular and membrane-spanning domains. J Biol Chem 2001 Sep 14; 276(37): 34607-16. View Abstract on PubMed

  • Wu AL, Wang J, Zheleznyak A, Brown EJ. Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane. Mol Cell 1999 Oct; 4(4): 619-25. View Abstract on PubMed

  • Green JM, Zhelesnyak A, Chung J, Lindberg FP, Sarfati M, Frazier WA, Brown EJ. Role of cholesterol in formation and function of a signaling complex involving alphavbeta3, integrin-associated protein (CD47), and heterotrimeric G proteins. J Cell Biol 1999 Aug 9; 146(3): 673-82. View Abstract on PubMed

  • Roach TI, Slater SE, White LS, Zhang X, Majerus PW, Brown EJ, Thomas ML. The protein tyrosine phosphatase SHP-1 regulates integrin-mediated adhesion of macrophages. Curr Biol 1998 Sep 10; 8(18): 1035-8. View Abstract on PubMed

  • Schorey JS, Carroll MC, Brown EJ. A macrophage invasion mechanism of pathogenic mycobacteria. Science 1997 Aug 22; 277(5329): 1091-3. View Abstract on PubMed

  • Lindberg FP, Bullard DC, Caver TE, Gresham HD, Beaudet AL, Brown EJ. Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice. Science 1996 Nov 1; 274(5288): 795-8. View Abstract on PubMed