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Wayne Fairbrother

 
Wayne Fairbrother
Wayne Fairbrother Director: Protein Engineering

Mentor Profile | Top Scientific Papers

Top Scientific Papers

  • Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, Garg P, Zobel K, Dynek JN, Elliott LO, Wallweber HJA, Flygare JA, Fairbrother WJ, Deshayes K, Dixit VM, Vucic D. IAP antagonists induce auto-ubiquitination of cIAPs, NF-κB activation, and TNFα-dependent apoptosis. Cell 131 2007; 669-681.

  • McCallum SA, Bazan JF, Merchant M, Yin J, Pan B, de Sauvage FJ, Fairbrother WJ. Structure of SAP18: a ubiquitin fold in histone deacetylase complex assembly. Biochemistry 2006 Oct 3; 45(39): 11974-82. View Abstract on PubMed

  • Varfolomeev E, Wayson SM, Dixit VM, Fairbrother WJ, Vucic D. The inhibitor of apoptosis protein fusion c-IAP2.MALT1 stimulates NF- kappaB activation independently of TRAF1 AND TRAF2. J Biol Chem 2006 Sep 29; 281(39): 29022-9. View Abstract on PubMed

  • Zobel K, Wang L, Varfolomeev E, Franklin MC, Elliott LO, Wallweber HJ, Okawa DC, Flygare JA, Vucic D, Fairbrother WJ, Deshayes K. Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs. ACS Chem Biol 2006 Sep 19; 1(8): 525-33. View Abstract on PubMed

  • Vucic D, Franklin MC, Wallweber HJ, Das K, Eckelman BP, Shin H, Elliott LO, Kadkhodayan S, Deshayes K, Salvesen GS, Fairbrother WJ. Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP. Biochem J 2005 Jan 1; 385(Pt 1): 11-20. View Abstract on PubMed

  • Stamos J, Eigenbrot C, Nakamura GR, Reynolds ME, Yin J, Lowman HB, Fairbrother WJ, Starovasnik MA. Convergent recognition of the IgE binding site on the high-affinity IgE receptor. Structure 2004 Jul; 12(7): 1289-301. View Abstract on PubMed

  • Franklin MC, Kadkhodayan S, Ackerly H, Alexandru D, Distefano MD, Elliott LO, Flygare JA, Mausisa G, Okawa DC, Ong D, Vucic D, Deshayes K, Fairbrother WJ. Structure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP). Biochemistry 2003 Jul 15; 42(27): 8223-31. View Abstract on PubMed

  • Gordon NC, Pan B, Hymowitz SG, Yin J, Kelley RF, Cochran AG, Yan M, Dixit VM, Fairbrother WJ, Starovasnik MA. BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site. Biochemistry 2003 May 27; 42(20): 5977-83. View Abstract on PubMed

  • Vucic D, Deshayes K, Ackerly H, Pisabarro MT, Kadkhodayan S, Fairbrother WJ, Dixit VM. SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP). J Biol Chem 2002 Apr 5; 277(14): 12275-9. View Abstract on PubMed

  • Pan B, Li B, Russell SJ, Tom JY, Cochran AG, Fairbrother WJ. Solution structure of a phage-derived peptide antagonist in complex with vascular endothelial growth factor. J Mol Biol 2002 Feb 22; 316(3): 769-87. View Abstract on PubMed

  • Humke EW, Shriver SK, Starovasnik MA, Fairbrother WJ, Dixit VM. ICEBERG: a novel inhibitor of interleukin-1beta generation. Cell 2000 Sep 29; 103(1): 99-111. View Abstract on PubMed

  • Fairbrother WJ, Christinger HW, Cochran AG, Fuh G, Keenan CJ, Quan C, Shriver SK, Tom JY, Wells JA, Cunningham BC. Novel peptides selected to bind vascular endothelial growth factor target the receptor-binding site. Biochemistry 1998 Dec 22; 37(51): 17754-64. View Abstract on PubMed

  • Fairbrother WJ, Liu J, Pisacane PI, Sliwkowski MX, Palmer AG 3rd. Backbone dynamics of the EGF-like domain of heregulin-alpha. J Mol Biol 1998 Jun 26; 279(5): 1149-61. View Abstract on PubMed

  • Fairbrother WJ, Champe MA, Christinger HW, Keyt BA, Starovasnik MA. Solution structure of the heparin-binding domain of vascular endothelial growth factor. Structure 1998 May 15; 6(5): 637-48. View Abstract on PubMed

  • Gitschier J, Moffat B, Reilly D, Wood WI, Fairbrother WJ. Solution structure of the fourth metal-binding domain from the Menkes copper-transporting ATPase. Nat Struct Biol 1998 Jan; 5(1): 47-54. View Abstract on PubMed

  • Starovasnik MA, Skelton NJ, O'Connell MP, Kelley RF, Reilly D, Fairbrother WJ. Solution structure of the E-domain of staphylococcal protein A. Biochemistry 1996 Dec 3; 35(48): 15558-69. View Abstract on PubMed

  • Lowman HB, Slagle PH, DeForge LE, Wirth CM, Gillece-Castro BL, Bourell JH, Fairbrother WJ. Exchanging interleukin-8 and melanoma growth-stimulating activity receptor binding specificities. J Biol Chem 1996 Jun 14; 271(24): 14344-52. View Abstract on PubMed

  • Jacobsen NE, Abadi N, Sliwkowski MX, Reilly D, Skelton NJ, Fairbrother WJ. High-resolution solution structure of the EGF-like domain of heregulin-alpha. Biochemistry 1996 Mar 19; 35(11): 3402-17. View Abstract on PubMed

  • Li B, Tom JY, Oare D, Yen R, Fairbrother WJ, Wells JA, Cunningham BC. Minimization of a polypeptide hormone. Science 1995 Dec 8; 270(5242): 1657-60. View Abstract on PubMed

  • Fairbrother WJ, Reilly D, Colby TJ, Hesselgesser J, Horuk R. The solution structure of melanoma growth stimulating activity. J Mol Biol 1994 Sep 23; 242(3): 252-70. View Abstract on PubMed

  • Reilly D, Fairbrother WJ. A novel isotope labeling protocol for bacterially expressed proteins. J Biomol NMR 1994 May; 4(3): 459-62. View Abstract on PubMed