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Sarah Hymowitz

Sarah Hymowitz
Sarah Hymowitz Associate Director: Structural Biology

Mentor Profile | Top Scientific Papers

Top Scientific Papers

  • Wu Y, Cain-Hom C, Choi L, de Leon GP, Chen Y, Wu X, Ridgway J, Schahin-Reed D, Dow GJ, Hagenbeek TJ, Stawicki S, Watts RJ, Zhang J, Choy R, Howard P, Kadyk L, Yan M, Callahan CA, Hymowitz SG, Siebel CW. Stabilizing receptor quiescence with synthetic antibodies enables therapeutic targeting of individual Notch receptors. Nature 2010.

  • Bosanac I, Maun HR, Scales SJ, Wen X, Lingel A, Bazan JF, de Sauvage FJ, Hymowitz SG, Lazarus RA. The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling. Nat Struct Mol Biol 2009 Jul; 16(7): 691-7. View Abstract on PubMed

  • Newton K, Matsumoto ML, Wertz IE, Kirkpatrick DS, Lill JR, Tan J, Dugger D, Gordon N, Sidhu SS, Fellouse FA, Komuves L, French DM, Ferrando RE, Lam C, Compaan D, Yu C, Bosanac I, Hymowitz SG, Kelley RF, Dixit VM. Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies. Cell 2008 Aug 22; 134(4): 668-78. View Abstract on PubMed

  • Adams C, Totpal K, Lawrence D, Marsters S, Pitti R, Yee S, Ross S, Deforge L, Koeppen S, Sagolla M, Compaan D, Lowman H, Hymowitz S, Ashkenazi A. Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5. Cell Death Differ 2008 Apr; 15(4): 751-61. View Abstract on PubMed

  • Seshasayee D, Lee WP, Zhou M, Shu J, Suto E, Zhang J, Diehl J, Austin C, Meng YG, Tan M, Bullens SL, Seeber S, Fuentes ME, Labrijn AF, Graus YM, Miller LA, Schelegle ES, Hyde DM, Wu LC, Hymowitz SG, Martin F. In vivo OX40L blockade inhibits TSLP-driven atopic inflammation. J Clin Invest 2007 Dec; 117(12): 3868-78. View Abstract on PubMed

  • Bourhis E, Hymowitz SG, Cochran AG. The mitotic regulator Survivin binds as a monomer to its functional interactor Borealin. J Biol Chem 2007 Nov 30; 282(48): 35018-23. View Abstract on PubMed

  • Wagner KM, Punnoose EA, Januario T, Lawrence DA, Pitti RM, Lancaster K, Lee D, von Goetz M, Yee SF, Totpal K, Huw L, Katta V, Cavet G, Hymowitz SG, Amler L, Ashkenazi A. Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL. Nat Med 2007 Sep; 13(9): 1070-7. View Abstract on PubMed

  • Compaan DM, Hymowitz SG. The crystal structure of the costimulatory OX40-OX40L complex. Structure 2006 Aug; 14(8): 1321-30. View Abstract on PubMed

  • Lee CV, Hymowitz SG, Wallweber HJ, Gordon NC, Billeci KL, Tsai SP, Compaan DM, Yin J, Gong Q, Kelley RF, DeForge LE, Martin F, Starovasnik MA, Fuh G. Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells. Blood 2006 Nov 1; 108(9): 3103-11. View Abstract on PubMed

  • Compaan DM, Gonzalez LC, Tom I, Loyet KM, Eaton D, Hymowitz SG. Attenuating lymphocyte activity: the crystal structure of the BTLA-HVEM complex. J Biol Chem 2005 Nov 25; 280(47): 39553-61. View Abstract on PubMed

  • Fellouse FA, Li B, Compaan DM, Peden AA, Hymowitz SG, Sidhu SS. Molecular recognition by a binary code. J Mol Biol 2005 May 20; 348(5): 1153-62. View Abstract on PubMed

  • Hymowitz SG, Patel DR, Wallweber HJ, Runyon S, Yan M, Yin J, Shriver SK, Gordon NC, Pan B, Skelton NJ, Kelley RF, Starovasnik MA. Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding. J Biol Chem 2005 Feb 25; 280(8): 7218-27. View Abstract on PubMed

  • Hymowitz SG, Compaan DM, Yan M, Wallweber HJ, Dixit VM, Starovasnik MA, de Vos AM. The crystal structures of EDA-A1 and EDA-A2: splice variants with distinct receptor specificity. Structure (Camb) 2003 Dec; 11(12): 1513-20. View Abstract on PubMed

  • Gordon NC, Pan B, Hymowitz SG, Yin J, Kelley RF, Cochran AG, Yan M, Dixit VM, Fairbrother WJ, Starovasnik MA. BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site. Biochemistry 2003 May 27; 42(20): 5977-83. View Abstract on PubMed

  • Hymowitz SG, Filvaroff EH, Yin J, Lee J, Cai L, Risser P, Maruoka M, Mao W, Foster J, Kelley RF, Pan G, Gurney AL, de Vos AM, Starovasnik MA. IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. EMBO J 2001 Oct 1; 20(19): 5332-41. View Abstract on PubMed

  • Yan M, Wang LC, Hymowitz SG, Schilbach S, Lee J, Goddard A, de Vos AM, Gao WQ, Dixit VM. Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. Science 2000 Oct 20; 290(5491): 523-7. View Abstract on PubMed

  • Hymowitz SG, O'Connell MP, Ultsch MH, Hurst A, Totpal K, Ashkenazi A, de Vos AM, Kelley RF. A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL. Biochemistry 2000 Feb 1; 39(4): 633-40. View Abstract on PubMed

  • Hymowitz SG, Christinger HW, Fuh G, Ultsch M, O'Connell M, Kelley RF, Ashkenazi A, de Vos AM. Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5. Mol Cell 1999 Oct; 4(4): 563-71. View Abstract on PubMed

  • Gillmor SA, Villasenor A, Fletterick R, Sigal E, Browner MF. The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity. Nat Struct Biol 1997 Dec; 4(12): 1003-9. View Abstract on PubMed