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Robert Kelley Senior Scientist: Antibody Engineering |
"The main interest of the Kelley lab is in using biophysical and protein engineering methods to more fully understand protein-protein interactions. A fundamental understanding of these interactions can aid in the discovery and optimization of therapeutic agents for human disease. A current focus of the group is on the engineering of antibody molecules for intervention in immunological disorders. Hybridoma and phage display approaches are used to discover antibodies against protein targets of potential therapeutic value. Protein engineering is used to 'humanize' rodent antibodies and also optimize therapeutic candidates on the basis of structure-function analysis. A distinction of the group is in the use of biophysical methods to determine the thermodynamics of both protein stability and protein-protein interactions. The lab is also active in technology development to speed the discovery of antibody molecules via phage display approaches."