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Henry Lowman

Henry Lowman
Henry Lowman Director: Antibody Engineering

Mentor Profile | Top Scientific Papers

Top Scientific Papers

  • Adams C, Totpal K, Lawrence D, Marsters S, Pitti R, Yee S, Ross S, Deforge, L, Koeppen H, Sagolla M, Compaan D, Lowman H, Hymowitz S, Ashkenazi A, Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5. Cell Death Differ 2008 Apr; 15(4): 751-61 View Abstract on PubMed

  • Junutula JR, Bhakta S, Raab H, Ervin KE, Eigenbrot C, Vandlen R, Scheller RH, Lowman HB. Rapid identification of reactive cysteine residues for site-specific labeling of antibody-Fabs. J Immunol Methods 2008 Mar 20; 332(1-2): 41-52. View Abstract on PubMed

  • Gerber HP, Wu X, Yu L, Wiesmann C, Liang XH, Lee CV, Fuh G, Olsson C, Damico L, Xie D, Meng YG, Gutierrez J, Corpuz R, Li B, Hall L, Rangell L, Ferrando R, Lowman H, Peale F, Ferrara N. Mice expressing a humanized form of VEGF-A may provide insights into the safety and efficacy of anti-VEGF antibodies. Proc Natl Acad Sci U S A 2007 Feb 27; 104(9): 3478-83. View Abstract on PubMed

  • Ferrara N, Damico L, Shams N, Lowman H, Kim R. Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration. Retina 2006 Oct; 26(8): 859-70. View Abstract on PubMed

  • Lien S, Pastor R, Sutherlin D, Lowman HB. A substrate phage approach for investigating caspase specificity. The Protein Journal 2004 23: 419-25.

  • Stamos J, Eigenbrot C, Nakamura GR, Reynolds ME, Yin J, Lowman HB, Fairbrother WJ, Starovasnik MA. Convergent recognition of the IgE binding site on the high-affinity IgE receptor. Structure 2004 Jul; 12(7): 1289-301. View Abstract on PubMed

  • Marvin JS, Lowman HB. Redesigning an antibody fragment for faster association with its antigen. Biochemistry 2003 Jun 17; 42(23): 7077-83. View Abstract on PubMed

  • Gerstner RB, Carter P, Lowman HB. Sequence plasticity in the antigen-binding site of a therapeutic anti-HER2 antibody. J Mol Biol 2002 Aug 30; 321(5): 851-62. View Abstract on PubMed

  • Nakamura GR, Reynolds ME, Chen YM, Starovasnik MA, Lowman HB. Stable "zeta" peptides that act as potent antagonists of the high-affinity IgE receptor. Proc Natl Acad Sci U S A 2002 Feb 5; 99(3): 1303-8. View Abstract on PubMed

  • Nakamura GR, Starovasnik MA, Reynolds ME, Lowman HB. A novel family of hairpin peptides that inhibit IgE activity by binding to the high-affinity IgE receptor. Biochemistry 2001 Aug 21; 40(33): 9828-35. View Abstract on PubMed

  • Skelton NJ, Chen YM, Dubree N, Quan C, Jackson DY, Cochran A, Zobel K, Deshayes K, Baca M, Pisabarro MT, Lowman HB. Structure-function analysis of a phage display-derived peptide that binds to insulin-like growth factor binding protein 1. Biochemistry 2001 Jul 24; 40(29): 8487-98. View Abstract on PubMed

  • Deforge LE, Lowman HB, Leong SR, Chuntharapai A, Jin Kim K, Hebert CA. A neutralizing monoclonal antibody specific for the dimer interface region of IL-8. Cytokine 2000 Nov; 12(11): 1620-9. View Abstract on PubMed

  • Chen Y, Wiesmann C, Fuh G, Li B, Christinger HW, McKay P, de Vos AM, Lowman HB. Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen. J Mol Biol 1999 Nov 5; 293(4): 865-81. View Abstract on PubMed

  • Dubaquie Y, Lowman HB. Total alanine-scanning mutagenesis of insulin-like growth factor I (IGF-I) identifies differential binding epitopes for IGFBP-1 and IGFBP-3. Biochemistry 1999 May 18; 38(20): 6386-96. View Abstract on PubMed

  • Muller YA, Chen Y, Christinger HW, Li B, Cunningham BC, Lowman HB, de Vos AM. VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface. Structure 1998 Sep 15; 6(9): 1153-67. View Abstract on PubMed

  • Lowman HB, Chen YM, Skelton NJ, Mortensen DL, Tomlinson EE, Sadick MD, Robinson IC, Clark RG. Molecular mimics of insulin-like growth factor 1 (IGF-1) for inhibiting IGF-1: IGF-binding protein interactions. Biochemistry 1998 Jun 23; 37(25): 8870-8. View Abstract on PubMed

  • Lowman HB, Slagle PH, DeForge LE, Wirth CM, Gillece-Castro BL, Bourell JH, Fairbrother. Exchanging interleukin-8 and melanoma growth-stimulating activity receptor binding specificities. J Biol Chem 1996 Jun 14; 271(24): 14344-52. View Abstract on PubMed

  • Lowman HB, Wells JA. Affinity maturation of human growth hormone by monovalent phage display. J Mol Biol 1993 Dec 5; 234(3): 564-78. View Abstract on PubMed

  • Lowman HB, Bass SH, Simpson N, Wells JA. Selecting high-affinity binding proteins by monovalent phage display. Biochemistry 1991 Nov 12; 30(45): 10832-8. View Abstract on PubMed

Book

  • Russel M, Lowman,HB, Clackson T. Introduction to phage biology and phage display. In: Clackson T, Lowman HB, editors. Phage display: a practical approach. Oxford: Oxford University Press; 2004. p. 1-26.