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Laura DeForge

Laura DeForge
Laura DeForge Senior Scientist: Assay & Automation Technology

Profile | Education/Background | Top Scientific Papers

Top Scientific Papers

  • DeForge LE, Shih DH, Kennedy D, Totpal K, Chuntharapai A, Bennett GL, Drummond JH, Siguenza P, Wong WL. Species-dependent serum interference in a sandwich ELISA for Apo2L/TRAIL. J Immunol Methods 2007 Mar 30; 320(1-2): 58-69. View Abstract on PubMed

  • Wiesmann C, Katschke KJ, Yin J, Helmy KY, Steffek M, Fairbrother WJ, McCallum SA, Embuscado L, DeForge L, Hass PE, van Lookeren Campagne M. Structure of C3b in complex with CRIg gives insights into regulation of complement activation. Nature 2006 Nov 9; 444(7116): 217-20. View Abstract on PubMed

  • Lee CV, Hymowitz SG, Wallweber HJ, Gordon NC, Billeci KL, Tsai SP, Compaan DM, Yin J, Gong Q, Kelley RF, DeForge LE, Martin F, Starovasnik MA, Fuh G. Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells. Blood 2006 Nov 1; 108(9): 3103-11. View Abstract on PubMed

  • Kelley RF, Totpal K, Lindstrom SH, Mathieu M, Billeci K, Deforge L, Pai R, Hymowitz SG, Ashkenazi A. Receptor-selective mutants of apoptosis-inducing ligand 2/tumor necrosis factor-related apoptosis-inducing ligand reveal a greater contribution of death receptor (DR) 5 than DR4 to apoptosis signaling. J Biol Chem 2005 Jan 21; 280(3): 2205-12. View Abstract on PubMed

  • DeForge LE, Cochran AG, Yeh SH, Robinson BS, Billeci KL, Wong WL. Substrate capacity considerations in developing kinase assays. Assay Drug Dev Technol 2004 Apr; 2(2): 131-40. View Abstract on PubMed

  • Miller K, Meng G, Liu J, Hurst A, Hsei V, Wong WL, Ekert R, Lawrence D, Sherwood S, DeForge L, Gaudreault J, Keller G, Sliwkowski M, Ashkenazi A, Presta L. Design, construction, and in vitro analyses of multivalent antibodies. J Immunol 2003 May 1; 170(9): 4854-61. View Abstract on PubMed

  • Leong SR, DeForge L, Presta L, Gonzalez T, Fan A, Reichert M, Chuntharapai A, Kim KJ, Tumas DB, Lee WP, Gribling P, Snedecor B, Chen H, Hsei V, Schoenhoff M, Hale V, Deveney J, Koumenis I, Shahrokh Z, McKay P, Galan W, Wagner B, Narindray D, Hebert C, Zapata G. Adapting pharmacokinetic properties of a humanized anti-interleukin-8 antibody for therapeutic applications using site-specific pegylation. Cytokine 2001 Nov 7; 16(3): 106-19. View Abstract on PubMed

  • Kelley SK, Harris LA, Xie D, Deforge L, Totpal K, Bussiere J, Fox JA. Preclinical studies to predict the disposition of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand in humans: characterization of in vivo efficacy, pharmacokinetics, and safety. J Pharmacol Exp Ther 2001 Oct; 299(1): 31-8. View Abstract on PubMed

  • Lawrence D, Shahrokh Z, Marsters S, Achilles K, Shih D, Mounho B, Hillan K, Totpal K, DeForge L, Schow P, Hooley J, Sherwood S, Pai R, Leung S, Khan L, Gliniak B, Bussiere J, Smith CA, Strom SS, Kelley S, Fox JA, Thomas D, Ashkenazi A. Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions. Nat Med 2001 Apr; 7(4): 383-5. View Abstract on PubMed

  • DeForge LE, Billeci KL, Kramer SM. Effect of IFN-gamma on the killing of S. aureus in human whole blood. Assessment of bacterial viability by CFU determination and by a new method using alamarBlue. J Immunol Methods 2000 Nov 1; 245(1-2): 79-89. View Abstract on PubMed

  • Deforge LE, Lowman HB, Leong SR, Chuntharapai A, Jin Kim K, Hebert CA. A neutralizing monoclonal antibody specific for the dimer interface region of IL-8. Cytokine 2000 Nov; 12(11): 1620-9. View Abstract on PubMed

  • Ashkenazi A, Pai RC, Fong S, Leung S, Lawrence DA, Marsters SA, Blackie C, Chang L, McMurtrey AE, Hebert A, DeForge L, Koumenis IL, Lewis D, Harris L, Bussiere J, Koeppen H, Shahrokh Z, Schwall RH. Safety and antitumor activity of recombinant soluble Apo2 ligand. J Clin Invest 1999 Jul; 104(2): 155-62. View Abstract on PubMed

  • Baly D, Gibson U, Allison D, DeForge L. Biological assays for C-X-C chemokines. Methods Enzymol 1997; 287: 69-88. View Abstract on PubMed

  • DeForge LE, Preston AM, Takeuchi E, Kenney J, Boxer LA, Remick DG. Regulation of interleukin 8 gene expression by oxidant stress. J Biol Chem 1993 Dec 5; 268(34): 25568-76. View Abstract on PubMed

  • DeForge LE, Fantone JC, Kenney JS, Remick DG. Oxygen radical scavengers selectively inhibit interleukin 8 production in human whole blood. J Clin Invest 1992 Nov; 90(5): 2123-9. View Abstract on PubMed