Skip to Content for Gloria Meng Menu for Gloria Meng About Us Menu Research Menu Development Menu Medicines Menu Investors Menu Media Menu Careers Menu
Banner Image

Gloria Meng

Gloria Meng
Gloria Meng Senior Scientist: Assay & Automation Technology

Profile | Education/Background | Top Scientific Papers

Top Scientific Papers

  • Gutierrez J, Konechny GE, Hong K, Burges A, Henry TD, Lambiase PD, Wong WL, Meng YG. A new ELISA for use in a 3-ELISA system to assess concentrations of VEGF splice variants and VEGF (110) in ovarian cancer tumors. Clin Chem 2008 Mar; 54(3): 597-601. View Abstract on PubMed

  • Shojaei F, Wu X, Zhong C, Yu L, Liang XH, Yao J, Blanchard D, Bais C, Peale FV, Van Bruggen N, Ho C, Ross J, Tan M, Carano RA, Meng YG, Ferrara N. Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Nature 2007 Dec 6; 450(7171): 825-31. View Abstract on PubMed

  • Seshasayee D, Lee WP, Zhou M, Shu J, Suto E, Zhang J, Diehl D, Austin CD, Meng YG, Tan M, Bullens SL, Seeber S, Fuentes ME, Labrijn AF, Graus YM, Miller LA, Schelegle ES, Hyde DM, Wu LC, Hymowitz SG, Martin F. In vivo blockage of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation. J Clin Invest 2007 Dec; 117(12): 3868-78. View Abstract on PubMed

  • Lu Y, Young J, Meng YG. Electrochemiluminescence to detect surface proteins on live cells. Curr Opin Pharmacol 2007 Oct; 7(5): 541-6. View Abstract on PubMed

  • Gerber HP, Wu X, Yu L, Wiesmann C, Liang XH, Lee CV, Fuh G, Olsson C, Damico L, Xie D, Meng YG, Gutierrez J, Corpuz R, Li B, Hall L, Rangell L, Ferrando R, Lowman H, Peale F, Ferrara N. Mice expressing a humanized form of VEGF-A may provide insights into the safety and efficacy of anti-VEGF antibodies. Proc Natl Acad Sci U S A 2007 Feb 27; 104(9): 3478-83. View Abstract on PubMed

  • Petkova SB, Akilesh S, Sproule TJ, Christianson GJ, Al Khabbaz H, Brown AC, Presta LG, Meng YG, Roopenian DC. Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease. Int Immunol 2006 Dec; 18(12): 1759-69. View Abstract on PubMed

  • Lu Y, Wong WL, Meng YG. A high throughput electrochemiluminescent cell-binding assay for therapeutic anti-CD20 antibody selection. J Immunol Methods 2006 Jul 31; 314(1-2): 74-9. View Abstract on PubMed

  • Tejada ML, Yu L, Dong J, Jung K, Meng G, Peale FV, Frantz GD, Hall L, Liang X, Gerber HP, Ferrara N. Tumor-driven paracrine platelet-derived growth factor receptor alpha signaling is a key determinant of stromal cell recruitment in a model of human lung carcinoma. Clin Cancer Res 2006 May 1; 12(9): 2676-88. View Abstract on PubMed

  • Malik AK, Baldwin ME, Peale F, Fuh G, Liang WC, Lowman H, Meng G, Ferrara N, Gerber HP. Redundant roles of VEGF-B and PlGF during selective VEGF-A blockade in mice. Blood 2006 Jan 15;107(2): 550-7. View Abstract on PubMed

  • Liang WC, Wu X, Peale FV, Lee CV, Meng YG, Gutierrez J, Fu L, Malik AK, Gerber HP, Ferrara N, Fuh G. Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF. J Biol Chem 2006 Jan 13; 281(2): 951-61. View Abstract on PubMed

  • Gong Q, Ou Q, Ye S, Lee WP, Cornelius J, Diehl L, Lin WY, Hu Z, Lu Y, Chen Y, Wu Y, Meng YG, Gribling P, Lin Z, Nguyen K, Tran T, Zhang Y, Rosen H, Martin F, Chan AC. Importance of cellular microenvironment and circulatory dynamics in B cell immunotherapy. J Immunol 2005 Jan 15;174(2): 817-26. View Abstract on PubMed

  • Hong K, Presta LG, Lu Y, Penn A, Adams C, Chuntharapai A, Yang J, Wong WL, Meng YG. Simple quantitative live cell and anti-idiotypic antibody based ELISA for humanized antibody directed to cell surface protein CD20. J Immunol Methods 2004 Nov; 294(1-2): 189-97. View Abstract on PubMed

  • Lambiase PD, Edwards RJ, Anthopoulos P, Rahman S, Meng YG, Bucknall CA, Redwood SR, Pearson JD, Marber MS. Circulating humoral factors and endothelial progenitor cells in patients with differing coronary collateral support. Circulation 2004 Jun 22; 109(24): 2986-92. View Abstract on PubMed

  • Konecny GE, Meng YG, Untch M, Wang HJ, Bauerfeind I, Epstein M, Stieber P, Vernes JM, Gutierrez J, Hong K, Beryt M, Hepp H, Slamon DJ, Pegram MD. Association between HER-2/neu and vascular endothelial growth factor expression predicts clinical outcome in primary breast cancer patients. Clin Cancer Res 2004 Mar 1; 10(5): 1706-16. View Abstract on PubMed

  • Eigenbrot C, Meng YG, Krishnamurthy R, Lipari MT, Presta L, Devaux B, Wong T, Moran P, Bullens S, Kirchhofer D. Structural insight into how an anti-idiotypic antibody against D3H44 (anti-tissue factor antibody) restores normal coagulation. J Mol Biol 2003 Aug 8; 331(2): 433-46. View Abstract on PubMed

  • Miller K, Meng G, Liu J, Hurst A, Hsei V, Wong WL, Ekert R, Lawrence D, Sherwood S, DeForge L, Gaudreault J, Keller G, Sliwkowski M, Ashkenazi A, Presta L. Design, construction, and in vitro analyses of multivalent antibodies. J Immunol 2003 May 1; 170(9): 4854-61. View Abstract on PubMed

  • Minor DR, Monroe D, Damico LA, Meng G, Suryadevara U, Elias L. A phase II study of thalidomide in advanced metastatic renal cell carcinoma. Invest New Drugs 2002 Nov; 20(4): 389-93. View Abstract on PubMed

  • Dennis MS, Zhang M, Meng YG, Kadkhodayan M, Kirchhofer D, Combs D, Damico LA. Albumin binding as a general strategy for improving the pharmacokinetics of proteins. J Biol Chem 2002 Sep 20; 277(38): 35035-43. View Abstract on PubMed

  • Presta LG, Shields RL, Namenuk AK, Hong K, Meng YG. Engineering therapeutic antibodies for improved function. Biochem Soc Trans 2002 Aug; 30(4): 487-90. View Abstract on PubMed

  • Shields RL, Lai J, Keck R, O'Connell LY, Hong K, Meng YG, Weikert SH, Presta LG. Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity. J Biol Chem 2002 Jul 26; 277(30): 26733-40. View Abstract on PubMed

  • Gerber HP, Malik AK, Solar GP, Sherman D, Liang XH, Meng G, Hong K, Marsters JC, Ferrara N. VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Nature 2002 Jun 27; 417(6892): 954-8. View Abstract on PubMed

  • Simmons LC, Reilly D, Klimowski L, Raju TS, Meng G, Sims P, Hong K, Shields RL, Damico LA, Rancatore P, Yansura DG. Expression of full-length immunoglobulins in Escherichia coli: rapid and efficient production of aglycosylated antibodies. J Immunol Methods 2002 May 1; 263(1-2): 133-47. View Abstract on PubMed

  • Presta L, Sims P, Meng YG, Moran P, Bullens S, Bunting S, Schoenfeld J, Lowe D, Lai J, Rancatore P, Iverson M, Lim A, Chisholm V, Kelley RF, Riederer M, Kirchhofer D. Generation of a humanized, high affinity anti-tissue factor antibody for use as a novel antithrombotic therapeutic. Thromb Haemost 2001 Mar; 85(3): 379-89. View Abstract on PubMed

  • Shields RL, Namenuk AK, Hong K, Meng YG, Rae J, Briggs J, Xie D, Lai J, Stadlen A, Li B, Fox JA, Presta LG. High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R. J Biol Chem 2001 Mar 2; 276(9): 6591-604. View Abstract on PubMed

  • Li B, Fuh G, Meng G, Xin X, Gerritsen ME, Cunningham B, de Vos AM. Receptor-selective variants of human vascular endothelial growth factor. Generation and characterization. J Biol Chem 2000 Sep 22; 275(38): 29823-8. View Abstract on PubMed

  • Albert TS, Meng YG, Simms P, Cohen RL, Phibbs RH. Thrombopoietin in the thrombocytopenic term and preterm newborn. Pediatrics 2000 Jun; 105(6): 1286-91. View Abstract on PubMed

  • Sims PW, Vasser M, Wong WL, Williams PM, Meng YG. immunopolymerase chain reaction using real-time polymerase chain reaction for detection. Anal Biochem 2000 Jun 1; 281(2): 230-2. View Abstract on PubMed

  • Idusogie EE, Presta LG, Gazzano-Santoro H, Totpal K, Wong PY, Ultsch M, Meng YG, Mulkerrin MG. Mapping of the C1q binding site on Rituxan, a chimeric antibody with a human IgG1 Fc. J Immunol 2000 Apr 15; 164(8): 4178-84. View Abstract on PubMed

  • Lebovic DI, Bentzien F, Chao VA, Garrett EN, Meng YG, Taylor RN. Induction of an angiogenic phenotype in endometriotic stromal cell cultures by interleukin-1beta. Mol Hum Reprod 2000 Mar; 6(3): 269-75. View Abstract on PubMed

  • Meng YG, Liang J, Wong WL, Chisholm V. Green fluorescent protein as a second selectable marker for selection of high producing clones from transfected CHO cells. Gene 2000 Jan 25; 242(1-2): 201-7. View Abstract on PubMed

  • Mordenti J, Thomsen K, Licko V, Berleau L, Kahn JW, Cuthbertson RA, Duenas ET, Ryan AM, Schofield C, Berger TW, Meng YG, Cleland J. Intraocular pharmacokinetics and safety of a humanized monoclonal antibody in rabbits after intravitreal administration of a solution or a PLGA microsphere formulation. Toxicol Sci 1999 Nov; 52(1): 101-6. View Abstract on PubMed

  • Peck-Radosavljevic M, Zacherl J, Wichlas M, Sims P, Meng YG, Panzer S, Lipinski E, Steininger R, Mühlbacher F, Pidlich J, Gangl A. Thrombopoietic cytokines and reversal of thrombocytopenia after liver transplantation. Eur J Gastroenterol Hepatol 1999 Feb; 11(2): 151-6. View Abstract on PubMed

  • Mordenti J, Cuthbertson RA, Ferrara N, Thomsen K, Berleau L, Licko V, Allen PC, Valverde CR, Meng YG, Fei DT, Fourre KM, Ryan AM. Comparisons of the intraocular tissue distribution, pharmacokinetics, and safety of 125I-labeled full-length and Fab antibodies in rhesus monkeys following intravitreal administration. Toxicol Pathol 1999 Sep-Oct; 27(5): 536-44. View Abstract on PubMed

  • Mordenti J, Thomsen K, Licko V, Chen H, Meng YG, Ferrara N. Efficacy and concentration-response of murine anti-VEGF monoclonal antibody in tumor-bearing mice and extrapolation to humans. Toxicol Pathol 1999 Jan-Feb; 27(1): 14-21. View Abstract on PubMed

  • Lin YS, Nguyen C, Mendoza JL, Escandon E, Fei D, Meng YG, Modi NB. Preclinical pharmacokinetics, interspecies scaling, and tissue distribution of a humanized monoclonal antibody against vascular endothelial growth factor. J Pharmacol Exp Ther 1999 Jan; 288(1): 371-8. View Abstract on PubMed

  • Sola MC, Juul SE, Meng YG, Garg S, Sims P, Calhoun DA, Dame JB, Christensen D. Thrombopoietin (Tpo) in the fetus and neonate: Tpo concentrations in preterm and term neonates, and organ distribution of Tpo and its receptor (c-mpl) during human fetal development. Early Hum Dev 1999 Jan; 53(3): 239-50. View Abstract on PubMed

  • Wiesmann C, Christinger HW, Cochran AG, Cunningham BC, Fairbrother WJ, Keenan CJ, Meng G, de Vos AM. Crystal structure of the complex between VEGF and a receptor-blocking peptide. Biochemistry 1998 Dec 22; 37(51): 17765-72. View Abstract on PubMed

  • Peck-Radosavljevic M, Wichlas M, Pidlich J, Sims P, Meng G, Zacherl J, Garg S, Datz C, Gangl A, Ferenci P. Blunted thrombopoietin response to interferon alfa-induced thrombocytopenia during treatment for hepatitis C. Hepatology 1998 Nov; 28(5): 1424-9. View Abstract on PubMed

  • O'Connor SJ, Meng YG, Rezaie AR, Presta LG. Humanization of an antibody against human protein C and calcium-dependence involving framework residues. Protein Eng 1998 Apr; 11(4): 321-8. View Abstract on PubMed

  • Miura N, Terai M, Meng YG, Sato T, Niimi H. Serum thrombopoietin levels in Kawasaki disease. Br J Haematol 1998 Feb; 100(2): 387-8. View Abstract on PubMed

  • Zwierzina H, Rollinger-Holzinger I, Nuessler V, Herold M, Meng YG. Endogenous serum thrombopoietin concentrations in patients with myelodysplastic syndromes. Leukemia 1998 Jan; 12(1): 59-64. View Abstract on PubMed

  • Presta LG, Chen H, O'Connor SJ, Chisholm V, Meng YG, Krummen L, Winkler M, Ferrara N. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res 1997 Oct 15 ;57(20): 4593-9. View Abstract on PubMed

  • Martin TG, Somberg KA, Meng YG, Cohen RL, Heid CA, de Sauvage FJ, Shuman MA. Thrombopoietin levels in patients with cirrhosis before and after orthotopic liver transplantation. Ann Intern Med 1997 Aug 15; 127(4): 285-8. View Abstract on PubMed

  • Peck-Radosavljevic M, Zacherl J, Meng YG, Pidlich J, Lipinski E, Längle F, Steininger R, Mühlbacher F, Gangl A. Is inadequate thrombopoietin production a major cause of thrombocytopenia in cirrhosis of the liver? J Hepatol 1997 Jul; 27(1): 127-31. View Abstract on PubMed

  • Thomas GR, Thibodeaux H, Errett CJ, Mathias J, Marian M, Meng G, Vandlen RL, Eaton DL. In vivo biological effects of various forms of thrombopoietin in a murine model of transient pancytopenia. Stem Cells 1996 14 Suppl 1: 246-55. View Abstract on PubMed

  • Meng YG, Martin TG, Peterson ML, Shuman MA, Cohen RL, Wong WL. Circulating thrombopoietin concentrations in thrombocytopenic patients, including cancer patients following chemotherapy, with or without peripheral blood progenitor cell transplantation. Br J Haematol 1996 Dec; 95(3): 535-41. View Abstract on PubMed

  • Soh EY, Sobhi SA, Wong MG, Meng YG, Siperstein AE, Clark OH, Duh QY. Thyroid-stimulating hormone promotes the secretion of vascular endothelial growth factor in thyroid cancer cell lines. Surgery 1996 Dec; 120(6): 944-7. View Abstract on PubMed

  • Chang M, Suen Y, Meng G, Buzby JS, Bussel J, Shen V, van de Ven C, Cairo MS. Differential mechanisms in the regulation of endogenous levels of thrombopoietin and interleukin-11 during thrombocytopenia: insight into the regulation of platelet production. Blood 1996 Nov 1; 88(9): 3354-62. View Abstract on PubMed

  • Shifren JL, Tseng JF, Zaloudek CJ, Ryan IP, Meng YG, Ferrara N, Jaffe RB, Taylor RN. Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis. J Clin Endocrinol Metab 1996 Aug; 81(8): 3112-8. View Abstract on PubMed

  • Meng YG, Singh N, Wong WL. Binding of cynomolgus monkey IgE to a humanized anti-human IgE antibody and human high affinity IgE receptor. Mol Immunol 1996 May-Jun; 33(7-8): 635-42. View Abstract on PubMed

  • Emmons RV, Reid DM, Cohen RL, Meng G, Young NS, Dunbar CE, Shulman NR. Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. Blood 1996 May 15; 87(10): 4068-71. View Abstract on PubMed

  • Mordenti J, Osaka G, Garcia K, Thomsen K, Licko V, Meng G. Pharmacokinetics and interspecies scaling of recombinant human factor VIII. Toxicol Appl Pharmacol 1996 Jan; 136(1): 75-8. View Abstract on PubMed