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Mark Dennis

Mark Dennis
Mark Dennis Senior Scientist: Antibody Engineering

Profile | Education/Background | Top Scientific Papers

Top Scientific Papers

  • Chen Y, Clark S, Wong T, Chen Y, Chen Y, Dennis MS, Luis E, Zhong F, Bheddah S, Koeppen H, Gogineni A, Ross S, Polakis P, Mallet W. Armed antibodies targeting the mucin repeats of the ovarian cancer antigen, MUC16, are highly efficacious in animal tumor models. Cancer Res 2007 May 15; 67(10): 4924-32. View Abstract on PubMed

  • Dennis MS, Jin H, Dugger D, Yang R, McFarland L, Ogasawara A, Williams S, Cole MJ, Ross S, Schwall R. Imaging tumors with an albumin-binding Fab, a novel tumor-targeting agent. Cancer Res 2007 Jan 1; 67(1): 254-61. View Abstract on PubMed

  • Liang WC, Dennis MS, Stawicki S, Chanthery Y, Pan Q, Chen Y, Eigenbrot C, Yin J, Koch AW, Wu X, Ferrara N, Bagri A, Tessier-Lavigne M, Watts RJ, Wu Y. Function blocking antibodies to neuropilin-1 generated from a designed human synthetic antibody phage library. J Mol Biol 2007 Feb 23; 366(3): 815-29. View Abstract on PubMed

  • Lee CV, Liang WC, Dennis MS, Eigenbrot C, Sidhu SS, Fuh G. High-affinity human antibodies from phage-displayed synthetic Fab libraries with a single framework scaffold. J Mol Biol 2004 Jul 23; 340(5): 1073-93. View Abstract on PubMed

  • Dennis MS, Zhang M, Meng YG, Kadkhodayan M, Kirchhofer D, Combs D, Damico LA. Albumin binding as a general strategy for improving the pharmacokinetics of proteins. J Biol Chem 2002 Sep 20; 277(38): 35035-43. View Abstract on PubMed

  • Gadek TR, Burdick DJ, McDowell RS, Stanley MS, Marsters JC, Paris KJ, Oare DA, Reynolds ME, Ladner C, Zioncheck KA, Lee WP, Gribling P, Dennis MS, Skelton NJ, Tumas DB, Clark KR, Keating SM, Beresini MH, Tilley JW, Presta LG, Bodary SC. Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule. Science 2002 Feb 8; 295(5557): 1086-9. View Abstract on PubMed

  • Dennis MS, Roberge M, Quan C, Lazarus RA. Selection and characterization of a new class of peptide exosite inhibitors of coagulation factor VIIa. Biochemistry 2001 Aug 14; 40(32): 9513-21. View Abstract on PubMed

  • Roberge M, Santell L, Dennis MS, Eigenbrot C, Dwyer MA, Lazarus RA. A novel exosite on coagulation factor VIIa and its molecular interactions with a new class of peptide inhibitors. Biochemistry 2001 Aug 14; 40(32): 9522-31. View Abstract on PubMed

  • Eigenbrot C, Kirchhofer D, Dennis MS, Santell L, Lazarus RA, Stamos J, Ultsch MH. The factor VII zymogen structure reveals reregistration of beta strands during activation. Structure (Camb) 2001 Jul 3; 9(7): 627-36. View Abstract on PubMed

  • Dennis MS, Eigenbrot C, Skelton NJ, Ultsch MH, Santell L, Dwyer MA, O'Connell MP, Lazarus RA. Peptide exosite inhibitors of factor VIIa as anticoagulants. Nature 2000 Mar 30; 404(6777): 465-70. View Abstract on PubMed

  • Dennis MS, Herzka A, Lazarus RA. Potent and selective Kunitz domain inhibitors of plasma kallikrein designed by phage display. J Biol Chem 1995 Oct 27; 270(43): 25411-7. View Abstract on PubMed

  • Dennis MS, Lazarus RA. Kunitz domain inhibitors of tissue factor-factor VIIa. I. Potent inhibitors selected from libraries by phage display. J Biol Chem 1994 Sep 2; 269(35): 22129-36. View Abstract on PubMed

  • Dennis MS, Lazarus RA. Kunitz domain inhibitors of tissue factor-factor VIIa. II. Potent and specific inhibitors by competitive phage selection. J Biol Chem 1994 Sep 2; 269(35): 22137-44. View Abstract on PubMed

  • Dennis MS, Carter P, Lazarus RA. Binding interactions of kistrin with platelet glycoprotein IIb-IIIa: analysis by site-directed mutagenesis. Proteins 1993 Mar; 15(3): 312-21. View Abstract on PubMed

  • Dennis MS, Henzel WJ, Pitti RM, Lipari MT, Napier MA, Deisher TA, Bunting S, Lazarus RA. Platelet glycoprotein IIb-IIIa protein antagonists from snake venoms: evidence for a family of platelet-aggregation inhibitors. Proc Natl Acad Sci U S A 1990 Apr; 87(7): 2471-5. View Abstract on PubMed

Books

  • Dennis MS, Lowman HB. Phage selection strategies for improved affinity and specificity of proteins and peptides. In: Clackson T, Lowman HB, editors. Phage display: a practical approach. Oxford: Oxford University Press, 2004. p. 61-83.

  • Dennis MS. Selection and screening strategies. In: Sidhu SS, editor. Phage display in biotechnology and drug discovery. Boca Raton: CRC Press; 2005. Vol. 3, p. 143-64.