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Simon Williams

Simon Williams
Simon Williams Senior Scientist: Biomedical Imaging

Profile | Education/Background | Top Scientific Papers | Awards & Honors

Top Scientific Papers

  • Flores JE, McFarland LM, Vanderbilt A, Ogasawara AK, Williams SP. The Effects Anesthetic Agent and Carrier Gas on Blood Glucose and Tissue Uptake in Mice Undergoing Dynamic FDG-PET Imaging: Sevoflurane and Isoflurane Compared in Air and in Oxygen. Mol Imaging Biol 2008 May 31; [Epub ahead of print] View Abstract on PubMed

  • Dennis MS, Jin H, Dugger D, Yang R, McFarland L, Ogasawara A, Williams S, Cole MJ, Ross S, Schwall R. Imaging tumors with an albumin-binding Fab, a novel tumor-targeting agent. Cancer Res 2007 Jan 1; 67(1): 254-61. View Abstract on PubMed

  • Greve JM, Chico TJ, Goldman H, Bunting S, Peale FV, Daugherty A, van Bruggen N, Williams SP. Magnetic resonance angiography reveals therapeutic enlargement of collateral vessels induced by VEGF in a murine model of peripheral arterial disease. J Magn Reson Imaging 2006 Nov; 24(5): 1124-32. View Abstract on PubMed

  • Botchway SW, Barba I, Jordan R, Harmston R, Haggie PM, Williams SP, Fulton AM, Parker AW, Brindle KM. A novel method for observing proteins in vivo using a small fluorescent label and multiphoton imaging. Biochem J 2005 Sep 15; 390(Pt 3): 787-90. View Abstract on PubMed

  • Carano RA, Ross AL, Ross J, Williams SP, Koeppen H, Schwall RH, Van Bruggen N. Quantification of tumor tissue populations by multispectral analysis. Magn Reson Med 2004 Mar; 51(3): 542-51. View Abstract on PubMed

  • Gerlai RT, McNamara A, Williams S, Phillips HS. Hippocampal dysfunction and behavioral deficit in the water maze in mice: an unresolved issue? Brain Res Bull 2002 Jan 1; 57(1): 3-9. View Abstract on PubMed

  • Williams SP, Gerber HP, Giordano FJ, Peale FV, Bernstein LJ, Bunting S, Chien KR, Ferrara N, van Bruggen N. Dobutamine stress cine-MRI of cardiac function in the hearts of adult cardiomyocyte-specific VEGF knockout mice. J Magn Reson Imaging 2001 Oct; 14(4): 374-82. View Abstract on PubMed

  • Giordano FJ, Gerber HP, Williams SP, VanBruggen N, Bunting S, Ruiz-Lozano P, Gu Y, Nath AK, Huang Y, Hickey R, Dalton N, Peterson KL, Ross J, Chien KR, Ferrara N. A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function. Proc Natl Acad Sci U S A 2001 May 8; 98(10): 5780-5. View Abstract on PubMed

  • Jin H, Yang R, Awad TA, Wang F, Li W, Williams SP, Ogasawara A, Shimada B, Williams PM, de Feo G, Paoni NF. Effects of early angiotensin-converting enzyme inhibition on cardiac gene expression after acute myocardial infarction. Circulation 2001 Feb 6; 103(5): 736-42. View Abstract on PubMed

  • van Bruggen N, Thibodeaux H, Palmer JT, Lee WP, Fu L, Cairns B, Tumas D, Gerlai R, Williams SP, van Lookeren Campagne M, Ferrara N. VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain. J Clin Invest 1999 Dec; 104(11): 1613-20. View Abstract on PubMed

  • van Lookeren Campagne M, Thomas GR, Thibodeaux H, Palmer JT, Williams SP, Lowe DG, van Bruggen N. Secondary reduction in the apparent diffusion coefficient of water, increase in cerebral blood volume, and delayed neuronal death after middle cerebral artery occlusion and early reperfusion in the rat. J Cereb Blood Flow Metab 1999 Dec; 19(12): 1354-64. View Abstract on PubMed

  • van Lookeren Campagne M, Thibodeaux H, van Bruggen N, Cairns B, Gerlai R, Palmer JT, Williams SP, Lowe DG. Evidence for a protective role of metallothionein-1 in focal cerebral ischemia. Proc Natl Acad Sci U S A 1999 Oct 26; 96(22): 12870-5. View Abstract on PubMed

  • Palmer JT, de Crespigny AJ, Williams S, Busch E, van Bruggen N. High-resolution mapping of discrete representational areas in rat somatosensory cortex using blood volume-dependent functional MRI. Neuroimage 1999 Apr; 9(4): 383-92. View Abstract on PubMed

  • Gerlai R, Williams SP, Cairns B, Van Bruggen N, Moran P, Shih A, Caras I, Sauer H, Phillips HS, Winslow JW. Protein targeting in the analysis of learning and memory: a potential alternative to gene targeting. Exp Brain Res 1998 Nov; 123(1-2): 24-35. View Abstract on PubMed

  • van Bruggen N, Busch E, Palmer JT, Williams SP, de Crespigny AJ. High-resolution functional magnetic resonance imaging of the rat brain: mapping changes in cerebral blood volume using iron oxide contrast media. J Cereb Blood Flow Metab 1998 Nov; 18(11): 1178-83. View Abstract on PubMed

  • Brindle KM, Fulton SM, Gillham H, Williams SP. Studies of metabolic control using NMR and molecular genetics. J Mol Recognit 1997 Jul-Aug; 10(4): 182-7. View Abstract on PubMed

  • Williams SP, Haggie PM, Brindle KM. 19F NMR measurements of the rotational mobility of proteins in vivo. Biophys J 1997 Jan; 72(1): 490-8. View Abstract on PubMed

  • Sheldon JG, Williams SP, Fulton AM, Brindle KM. 31P NMR magnetization transfer study of the control of ATP turnover in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 1996 Jun 25; 93(13): 6399-404. View Abstract on PubMed

  • Brindle KM, Fulton AM, Williams SP. Experimental approaches to studying enzymes in vivo: The application of NMR methods to genetically manipulated organisms. In: Bittar E, Brindle KM, editors. Enzymology IN VIVO (Adv. Mol. Cell. Biol. Vol 11). London: Jai Press; 1995.

  • Brindle KM, Fulton AM, Williams SP. Studies of cellular energetics using 31P NMR. In: Brown GC, Cooper CE, editors. Bioenergetics: A practical approach. Oxford: Oxford University Press; 1995.

  • Brindle KM, Fulton AM, Williams SP. A combined NMR and molecular genetic approach to studying enzymes in vivo. In: Gillies RJ, editor. NMR in physiology and biomedicine. San Diego: Academic Press; 1994.

  • Williams SP, Fulton AM, Brindle KM. Estimation of the intracellular free ADP concentration by 19F NMR studies of fluorine-labeled yeast phosphoglycerate kinase in vivo. Biochemistry 1993 May 11; 32(18): 4895-902. View Abstract on PubMed

  • Brindle KM, Fulton AM, Williams SP. Enzymology in vivo using NMR and molecular genetics. J Mol Recognit 1993 Dec; 6(4): 159-65. View Abstract on PubMed

  • Brindle KM, Davies SE, Williams SP. A combined n.m.r. and molecular biological approach to studying enzymes in vivo. Biochem Soc Trans 1991 Nov; 19(4): 997-1001. View Abstract on PubMed

  • Brindle K, Williams SP, Boulton M. 19F NMR detection of a fluorine-labeled enzyme in vivo. Fed Eur Biochem Soc Lett 1989 255: 121-24.