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Hilary Clark

Hilary Clark
Hilary Clark Senior Scientist: Bioinformatics & Computational Biology

Profile | Education/Background | Top Scientific Papers | Awards & Honors

Top Scientific Papers

  • Noble CL, Abbas AR, Lees CW, Cornelius J, Toy K, Modrusan Z, Clark H, Arnott I, Penman ID, Satsangi J, Diehl L. Characterisation of genome wide expression in colonic and terminal ileal biopsies in Crohn's disease. Inflammatory Bowel Diseases 2010; (in press)

  • Xi H, Katschke KJ Jr, Helmy KY, Wark PA, Kljavin N, Clark H, Eastham-Anderson J, Shek T, Roose-Girma M, Ghilardi N, van Lookeren Campagne M. Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1. J Exp Med 2010 Jan 18; 207(1): 7-16, S1-5. View Abstract on PubMed

  • Abbas AR, Wolslegel K, Seshasayee D, Modrusan Z, Clark HF. Deconvolution of blood microarray data identifies cellular activation patterns in systemic lupus erythematosus. PLoS One 2009 Jul 1; 4(7): e6098. View Abstract on PubMed

  • Yu X, Harden K, Gonzalez L, Francesco M, Chiang E, Irving B, Tom I, Ivelja S, Refino CJ, Clark H, Eaton D, Grogan JL. The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat Immunol 2009 Jan; 10(1): 48-57. Epub 2008 Nov 16. View Abstract on PubMed

  • Noble CL, Abbas AR, Cornelius J, Lees CW, Ho GT, Toy K, Modrusan Z, Pal N, Zhong F, Chalasani S, Clark H, Arnott ID, Penman ID, Satsangi J, Diehl L. Regional Variation in Gene Expression in the Healthy Colon is Dysregulated in Ulcerative Colitis. Gut 2008 Oct; 57(10): 1398-405. Epub 2008 Jun 3. View Abstract on PubMed

  • Gorgani NN, Ma Y, Clark HF. Gene signatures reflect the marked heterogeneity of tissue-resident macrophages. Immunol Cell Biol 2008 Mar-Apr; 86(3): 246-54. Epub 2007 Nov 13. View Abstract on PubMed

  • Raelson JV, Little RD, Ruether A, Fournier H, Paquin B, Van Eerdewegh P, Bradley WE, Croteau P, Nguyen-Huu Q, Segal J, Debrus S, Allard R, Rosenstiel P, Franke A, Jacobs G, Nikolaus S, Vidal JM, Szego P, Laplante N, Clark HF, Paulussen RJ, Hooper JW, Keith TP, Belouchi A, Schreiber S. Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci. Proc Natl Acad Sci U S A 2007 Sep 11; 104(37): 14747-52. View Abstract on PubMed

  • Abbas AR, Baldwin D, Ma Y, Ouyang W, Gurney A, Martin F, Fong S, van Lookeren Campagne M, Godowski P, Williams PM, Chan AC, Clark HF. Immune response in silico (IRIS): immune-specific genes identified from a compendium of microarray expression data. Genes Immun 2005 Jun; 6(4): 319-31. View Abstract on PubMed

  • Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res 2003 Oct; 13(10): 2265-70. View Abstract on PubMed

  • Gong X, Kaushal S, Ceccarelli E, Bogdanova N, Neville C, Nguyen T, Clark H, Khatib ZA, Valentine M, Look AT, Rosenthal N. Developmental regulation of Zbu1, a DNA-binding member of the SWI2/SNF2 family. Dev Biol 1997 Mar 15; 183(2): 166-82. View Abstract on PubMed

  • Clark HF, Brentrup D, Schneitz K, Bieber A, Goodman C, Noll M. Dachsous encodes a member of the cadherin superfamily that controls imaginal disc morphogenesis in Drosophila. Genes Dev 1995 Jun 15; 9(12): 1530-42. View Abstract on PubMed