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John Monroe

John Monroe
John Monroe Senior Director: Immunology Diagnostics & Biomarkers

Profile | Education/Background | Top Scientific Papers | Awards & Honors

Top Scientific Papers

  • Cozma D, Yu D, Hodawadekar S, Azvolinsky A, Grande S, Tobias JW, Metzgar MH, Paterson J, Erikson J, Marafioti T, Monroe JG, Atchison ML, Thomas-Tikhonenko A. B cell activator PAX5 promotes lymphomagenesis through stimulation of B cell receptor signaling. J Clin Invest 2007 Sep; 117(9): 2602-10. View Abstract on PubMed

  • Ross SR, Schmidt JW, Katz E, Cappelli L, Hultine S, Gimotty P, Monroe JG. An immunoreceptor tyrosine activation motif in the mouse mammary tumor virus envelope protein plays a role in virus-induced mammary tumors. J Virol 2006 Sep; 80(18): 9000-8. View Abstract on PubMed

  • Grande SM, Katz E, Crowley JE, Bernardini MS, Ross SR, Monroe JG. Cellular ITAM-containing proteins are oncoproteins in nonhematopoietic cells. Oncogene 2006 May 4; 25(19): 2748-57. View Abstract on PubMed

  • Monroe JG. ITAM-mediated tonic signalling through pre-BCR and BCR complexes. Nat Rev Immunol 2006 Apr; 6(4): 283-94. View Abstract on PubMed

  • Karnell FG, Brezski RJ, King LB, Silverman MA, Monroe JG. Membrane cholesterol content accounts for developmental differences in surface B cell receptor compartmentalization and signaling. J Biol Chem 2005 Jul 8; 280(27): 25621-8. View Abstract on PubMed

  • Katz E, Lareef MH, Rassa JC, Grande SM, King LB, Russo J, Ross SR, Monroe JG. MMTV Env encodes an ITAM responsible for transformation of mammary epithelial cells in three-dimensional culture. J Exp Med 2005 Feb 7; 201(3): 431-9. View Abstract on PubMed

  • Fuentes-Pananá EM, Bannish G, Shah N, Monroe JG. Basal Igalpha/Igbeta signals trigger the coordinated initiation of pre-B cell antigen receptor-dependent processes. J Immunol 2004 Jul 15; 173(2): 1000-11. View Abstract on PubMed

  • Yu D, Allman D, Goldschmidt MH, Atchison ML, Monroe JG, Thomas-Tikhonenko A. Oscillation between B-lymphoid and myeloid lineages in Myc-induced hematopoietic tumors following spontaneous silencing/reactivation of the EBF/Pax5 pathway. Blood 2003 Mar 1; 101(5): 1950-5. View Abstract on PubMed

  • Bannish G, Fuentes-Pananá EM, Cambier JC, Pear WS, Monroe JG. Ligand-independent signaling functions for the B lymphocyte antigen receptor and their role in positive selection during B lymphopoiesis. J Exp Med 2001 Dec 3; 194(11): 1583-96. View Abstract on PubMed

  • Chiang MY, Monroe JG. Role for transcription Pax5A factor in maintaining commitment to the B cell lineage by selective inhibition of granulocyte-macrophage colony-stimulating factor receptor expression. J Immunol 2001 May 15; 166(10): 6091-8. View Abstract on PubMed

  • King LB, Monroe JG. Immunology. B cell receptor rehabilitation--pausing to reflect. Science 2001 Feb 23; 291(5508): 1503-5. View Abstract on PubMed

  • Chung JB, Baumeister MA, Monroe JG. Cutting edge: differential sequestration of plasma membrane-associated B cell antigen receptor in mature and immature B cells into glycosphingolipid-enriched domains. J Immunol 2001 Jan 15; 166(2): 736-40. View Abstract on PubMed

  • Chiang MY, Monroe JG. BSAP/Pax5A expression blocks survival and expansion of early myeloid cells implicating its involvement in maintaining commitment to the B-lymphocyte lineage. Blood 1999 Dec 1; 94(11): 3621-32. View Abstract on PubMed

  • King LB, Norvell A, Monroe JG. Antigen receptor-induced signal transduction imbalances associated with the negative selection of immature B cells. J Immunol 1999 Mar 1; 162(5): 2655-62. View Abstract on PubMed

  • Sandel PC, Monroe JG. Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter. Immunity 1999 Mar; 10(3): 289-99. View Abstract on PubMed

  • Przybylski GK, Goldman J, Ng VL, McGrath MS, Herndier BG, Schenkein DP, Monroe JG, Silberstein LE. Evidence for early B-cell activation preceding the development of Epstein-Barr virus-negative acquired immunodeficiency syndrome-related lymphoma. Blood 1996 Dec 15; 88(12): 4620-9. View Abstract on PubMed

  • Maltzman JS, Carman JA, Monroe JG. Role of EGR1 in regulation of stimulus-dependent CD44 transcription in B lymphocytes. Mol Cell Biol 1996 May; 16(5): 2283-94. View Abstract on PubMed

  • Maltzman JS, Carmen JA, Monroe JG. Transcriptional regulation of the Icam-1 gene in antigen receptor- and phorbol ester-stimulated B lymphocytes: role for transcription factor EGR1. J Exp Med 1996 Apr 1; 183(4): 1747-59. View Abstract on PubMed

  • Norvell A, Monroe JG. Acquisition of surface IgD fails to protect from tolerance-induction. Both surface IgM- and surface IgD-mediated signals induce apoptosis of immature murine B lymphocytes. J Immunol 1996 Feb 15; 156(4): 1328-32. View Abstract on PubMed

  • Norvell A, Mandik L, Monroe JG. Engagement of the antigen-receptor on immature murine B lymphocytes results in death by apoptosis. J Immunol 1995 May 1; 154(9): 4404-13. View Abstract on PubMed

  • McMahon SB, Monroe JG. A ternary complex factor-dependent mechanism mediates induction of egr-1 through selective serum response elements following antigen receptor cross-linking in B lymphocytes. Mol Cell Biol 1995 Feb; 15(2): 1086-93. View Abstract on PubMed

  • McMahon SB, Monroe JG. Activation of the p21ras pathway couples antigen receptor stimulation to induction of the primary response gene egr-1 in B lymphocytes. J Exp Med 1995 Jan 1; 181(1): 417-22. View Abstract on PubMed

  • Yellen AJ, Glenn W, Sukhatme VP, Cao XM, Monroe JG. Signaling through surface IgM in tolerance-susceptible immature murine B lymphocytes. Developmentally regulated differences in transmembrane signaling in splenic B cells from adult and neonatal mice. J Immunol 1991 Mar 1; 146(5): 1446-54. View Abstract on PubMed

  • Seyfert VL, McMahon SB, Glenn WD, Yellen AJ, Sukhatme VP, Cao XM, Monroe JG. Methylation of an immediate-early inducible gene as a mechanism for B cell tolerance induction. Science 1990 Nov 9; 250(4982): 797-800. View Abstract on PubMed

  • Seyfert VL, Sukhatme VP, Monroe JG. Differential expression of a zinc finger-encoding gene in response to positive versus negative signaling through receptor immunoglobulin in murine B lymphocytes. Mol Cell Biol 1989 May; 9(5): 2083-8. View Abstract on PubMed

  • Monroe JG, Seyfert VL, Owen CS, Sykes N. Isolation and characterization of a B lymphocyte mutant with altered signal transduction through its antigen receptor. J Exp Med 1989 Mar 1; 169(3): 1059-70. View Abstract on PubMed