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Andrew C. Chan

Andrew C. Chan
Andrew C. Chan Senior Vice President: Immunology and Antibody Engineering

Profile | Education/Background | Top Scientific Papers | Awards & Honors

Top Scientific Papers

  • Yeh JY, Sidhu SS, Chan AC. Regulation of a late phase of T cell polarity and effector functions by Crtam. Cell 2008 Mar 7; 132: 846-59. View Abstract on PubMed

  • Liu J, Wang L, Harvey-White J, Osei-Hyiaman D, Razdan R, Gong Q, Chan AC, Zhou Z, Huang BX, Kim HY, Kunos, G. A biosynthetic pathway for anandamide. Proc Natl Acad Sci USA 2006 Sep 5; 103(36): 13345-50. View Abstract on PubMed

  • Foger N, Rangell L, Danilenko DM, Chan AC. Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis. Science 2006 Aug 11; 313(5788): 839-42. View Abstract on PubMed

  • Lee KH, Feig C, Tchikov V, Schickel R, Hallas C, Schutze S, Peter ME, Chan AC. The role of receptor internalization in CD95 signaling. EMBO J 2006 Mar 8; 25(5): 1009-23. View Abstract on PubMed

  • Martin F, Chan AC. Pathogenic roles of B cells in human autoimmunity; insights from the clinic. Immunity 2004 May; 20(5): 517-27. View Abstract on PubMed

  • Hasegawa K, Martin F, Huang G, Tumas D, Diehl L, Chan AC. PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells. Science 2004 Jan 30; 303(5658): 685-9. View Abstract on PubMed

  • Kemper C, Chan AC, Green JM, Brett KA, Murphy KM, Atkinson JP. Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature 2003 Jan 23; 421(6921): 388-92. View Abstract on PubMed

  • Chiu CW, Dalton M, Ishiai M, Kurosaki T, Chan AC. BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins. EMBO J 2002 Dec 2; 21(23): 6461-72. View Abstract on PubMed

  • Kabak S, Skaggs BJ, Gold MR, Affolter M, West KL, Foster MS, Siemasko K, Chan AC, Aebersold R, Clark MR. The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways. Mol Cell Biol 2002 Apr; 22(8): 2524-35. View Abstract on PubMed

  • Lee KH, Holdorf AD, Dustin ML, Chan AC, Allen PM, Shaw AS. T cell receptor signaling precedes immunological synapse formation. Science 2002 Feb 22; 295(5559): 1539-42. View Abstract on PubMed

  • Mora AL, Stanley S, Armistead W, Chan AC, Boothby M. Inefficient ZAP-70 phosphorylation and decreased thymic selection in vivo result from inhibition of NF-kappaB/Rel. J Immunol 2001 Nov 15; 167(10): 5628-35. View Abstract on PubMed

  • Gong Q, Jin X, Akk AM, Foger N, White M, Gong G, Wardenburg JB, Chan AC. Requirement for tyrosine residues 315 and 319 within zeta chain-associated protein 70 for T cell development. J Exp Med 2001 Aug 20; 194(4): 507-18. View Abstract on PubMed

  • Engels N, Merchant M, Pappu R, Chan AC, Longnecker R, Wienands J. Epstein-Barr virus latent membrane protein 2A (LMP2A) employs the SLP-65 signaling module. J Exp Med 2001 Aug 6; 194(3): 255-64. View Abstract on PubMed

  • Gong Q, Cheng AM, Akk AM, Alberola-Ila J, Gong G, Pawson T, Chan AC. Disruption of T cell signaling networks and development by Grb2 haploid insufficiency. Nat Immunol 2001 Jan; 2(1): 29-36. View Abstract on PubMed

  • Minegishi Y, Rohrer J, Coustan-Smith E, Lederman HM, Pappu R, Campana D, Chan AC, Conley ME. An essential role for BLNK in human B cell development. Science 1999 Dec 3; 286(5446): 1954-7. View Abstract on PubMed

  • Pappu R, Cheng AM, Li B, Gong Q, Chiu C, Griffin N, White M, Sleckman BP, Chan AC. Requirement for B cell linker protein (BLNK) in B cell development. Science 1999 Dec 3; 286(5446): 1949-54. View Abstract on PubMed

  • Ishiai M, Kurosaki M, Pappu R, Okawa K, Ronko I, Fu C, Shibata M, Iwamatsu A, Chan AC, Kurosaki T. BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells. Immunity 1999 Jan; 10(1): 117-25. View Abstract on PubMed

  • Bubeck Wardenburg J, Pappu R, Bu JY, Mayer B, Chernoff J, Straus D, Chan AC. Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76. Immunity 1998 Nov; 9(5): 607-16. View Abstract on PubMed

  • Fu C, Turck CW, Kurosaki T, Chan AC. BLNK: a central linker protein in B cell activation. Immunity 1998 Jul; 9(1): 93-103. View Abstract on PubMed

  • Cheng AM, Negishi I, Anderson SJ, Chan AC, Bolen J, Loh DY, Pawson T. The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling. Proc Natl Acad Sci U S A 1997 Sep 2; 94(18): 9797-801. View Abstract on PubMed

  • Wardenburg JB, Fu C, Jackman JK, Flotow H, Wilkinson SE, Williams DH, Johnson R, Kong G, Chan AC, Findell PR. Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function. J Biol Chem 1996 Aug 16; 271(33): 19641-4. View Abstract on PubMed

  • Negishi I, Motoyama N, Nakayama K, Nakayama K, Senju S, Hatakeyama S, Zhang Q, Chan AC, Loh DY. Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature 1995 Aug 3; 376(6539): 435-8, View Abstract on PubMed

  • Chan AC, Dalton M, Johnson R, Kong GH, Wang T, Thoma R, Kurosaki T. Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function. EMBO J 1995 Jun 1; 14(11): 2499-508. View Abstract on PubMed

  • Chan AC, Kadlecek TA, Elder ME, Filipovich AH, Kuo WL, Iwashima M, Parslow TG, Weiss A. ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency. Science 1994 Jun 10; 264(5165): 1599-601 View Abstract on PubMed

  • Elder ME, Lin D, Clever J, Chan AC, Hope TJ, Weiss A, Parslow TG. Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. Science 1994 Jun 10; 264(5165): 1596-9. View Abstract on PubMed

  • Chan AC, Iwashima M, Turck CW, Weiss A. ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain. Cell 1992 Nov 13; 71(4): 649-62. View Abstract on PubMed

  • Chan AC, Irving BA, Fraser JD, Weiss A. The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein. Proc Natl Acad Sci U S A 1991 Oct 15; 88(20): 9166-70. View Abstract on PubMed

  • Chan AC, Mitchell KR, Munns TW, Karp DR, Atkinson JP. Identification and partial characterization of the secreted form of the fourth component of human complement: evidence that it is different from major plasma form. Proc Natl Acad Sci U S A 1983 Jan; 80(1): 268-72. View Abstract on PubMed