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Frederic de Sauvage Vice President: Molecular Biology |
Top Scientific Papers
- Rubin LL, de Sauvage FJ. Targeting the Hedgehog pathway in cancer. Nat Rev Drug Discov 2006 Dec; 5(12): 1026-33. View Abstract on PubMed
- Batten M, Li J, Yi S, Kljavin NM, Danilenko DM, Lucas S, Lee J, de Sauvage FJ, Ghilardi N. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat Immunol 2006 Sep; 7(9): 929-36. View Abstract on PubMed
- Merchant M, Evangelista M, Luoh SM, Frantz GD, Chalasani S, Carano RA, van Hoy M, Ramirez J, Ogasawara AK, McFarland LM, Filvaroff EH, French DM, de Sauvage FJ. Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus. Mol Cell Biol 2005 Aug; 25(16): 7054-68. View Abstract on PubMed
- Ghilardi N, Kljavin N, Chen Q, Lucas S, Gurney AL, De Sauvage FJ. Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice. J Immunol 2004 Mar 1; 172(5): 2827-33. View Abstract on PubMed
- Lucas S, Ghilardi N, Li J, de Sauvage FJ. IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms. Proc Natl Acad Sci U S A 2003 Dec 9; 100(25): 15047-52. View Abstract on PubMed
- Aggarwal S, Ghilardi N, Xie MH, de Sauvage FJ, Gurney AL.
Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem 2003 Jan 17; 278(3): 1910-4. View Abstract on PubMed
- Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, Gurney A, Grewal IS, de Sauvage FJ. Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature 2000 Oct 19; 407(6806): 916-20. View Abstract on PubMed
- Jingwu Xie, Maximilien Murone, Shiuh-Ming Luoh, Anne Ryan, Chaohui Zhang, Quimin Gu, Jeannette M. Bonifas, Ching-Wan Lam, Mary Hynes, Audrey Goddard, Xie Xie J, Murone M, Luoh SM, Ryan A, Gu Q, Zhang C, Bonifas JM, Lam CW, Hynes M, Goddard A, Rosenthal A, Epstein EH Jr, de Sauvage FJ. Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature 1998 Jan 1; 391(6662): 90-2. View Abstract on PubMed
- Stone DM, Hynes M, Armanini M, Swanson TA, Gu Q, Johnson RL, Scott MP, Pennica D, Goddard A, Phillips H, Noll M, Hooper JE, de Sauvage F, Rosenthal A. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 1996 Nov 14; 384(6605): 129-34. View Abstract on PubMed
- Fielder PJ, Gurney AL, Stefanich E, Marian M, Moore MW, Carver-Moore K, de Sauvage FJ. Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets. Blood 1996 Mar 15; 87(6): 2154-61. View Abstract on PubMed
- de Sauvage FJ, Carver-Moore K, Luoh SM, Ryan A, Dowd M, Eaton DL, Moore MW. Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. J Exp Med 1996 Feb 1; 183(2): 651-6. View Abstract on PubMed
- Gurney AL, Carver-Moore K, de Sauvage FJ, Moore MW. Thrombocytopenia in c-mpl-deficient mice. Science 1994 Sep 2; 265(5177): 1445-7. View Abstract on PubMed
- de Sauvage FJ, Hass PE, Spencer SD, Malloy BE, Gurney AL, Spencer SA, Darbonne WC, Henzel WJ, Wong SC, Kuang WJ, Oles K, Hultgren B, Solber, L, Goeddel D, Eaton D. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 1994 Jun 16; 369(6481): 533-8. View Abstract on PubMed
- de Sauvage F, Octave JN. A novel mRNA of the A4 amyloid precursor gene coding for a possibly secreted protein. Science 1989 Aug 11; 245(4918): 651-3. View Abstract on PubMed