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Frederic de Sauvage

Frederic de Sauvage
Frederic de Sauvage Vice President: Molecular Biology

Profile | Education/Background | Top Scientific Papers

Top Scientific Papers

  • Bazan JF, de Sauvage FJ. Structural ties between cholesterol transport and morphogen signaling. Cell 2009 Sep 18; 138(6): 1055-6. View Abstract on PubMed

  • Yauch RL, Dijkgraaf GJ, Alicke B, Januario T, Ahn CP, Holcomb T, Pujara K, Stinson J, Callahan CA, Tang T, Bazan JF, Kan Z, Seshagiri S, Hann CL, Gould SE, Low JA, Rudin CM, de Sauvage FJ. Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma. Science 2009 Sep 2. View Abstract on PubMed

  • Von Hoff DD, LoRusso PM, Rudin CM, Reddy JC, Yauch RL, Tibes R, Weiss GJ, Borad MJ, Hann CL, Brahmer JF, Mackey HM, Lum BL, Darbonne WC, Marsters JC Jr, de Sauvage FJ, Low JA. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med 2009 Sep 17; 361(12): 1164-72. View Abstract on PubMed

  • Rudin CM, Hann CL, Laterra J, Yauch RL, Callahan CA, Fu L, Holcomb T, Stinson J, Gould SE, Coleman B, LoRusso PM, Von Hoff DD, de Sauvage FJ, Low JA. Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N Engl J Med 2009 Sep 17; 361(12): 1173-8. View Abstract on PubMed

  • Tian H, Callahan CA, DuPree KJ, Darbonne WC, Ahn CP, Scales SJ, de Sauvage FJ. Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. Proc Natl Acad Sci USA 2009 Mar 17; 106(11): 4254-9. View Abstract on PubMed

  • Evangelista M, Lim TY, Lee J, Parker L, Ashique A, Peterson AS, Ye W, Davis DP, de Sauvage FJ. Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction. Sci Signal 2008 Sep 30; 1(39): ra7. View Abstract on PubMed

  • Yauch RL, Gould SE, Scales SJ, Tang T, Tian H, Ahn CP, Marshall D, Fu L, Januario T, Kallop D, Nannini-Pepe M, Kotkow K, Marsters JF, Rubin LL, de Sauvage FJ. A paracrine requirement for hedgehog signalling in cancer. Nature 2008 Sep 18; 455(7211): 406-10. View Abstract on PubMed

  • Rubin LL, de Sauvage FJ. Targeting the Hedgehog pathway in cancer. Nat Rev Drug Discov 2006 Dec; 5(12): 1026-33. View Abstract on PubMed

  • Batten M, Li J, Yi S, Kljavin NM, Danilenko DM, Lucas S, Lee J, de Sauvage FJ, Ghilardi N. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat Immunol 2006 Sep; 7(9): 929-36. View Abstract on PubMed

  • Merchant M, Evangelista M, Luoh SM, Frantz GD, Chalasani S, Carano RA, van Hoy M, Ramirez J, Ogasawara AK, McFarland LM, Filvaroff EH, French DM, de Sauvage FJ. Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus. Mol Cell Biol 2005 Aug; 25(16): 7054-68. View Abstract on PubMed

  • Ghilardi N, Kljavin N, Chen Q, Lucas S, Gurney AL, De Sauvage FJ. Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice. J Immunol 2004 Mar 1; 172(5): 2827-33. View Abstract on PubMed

  • Lucas S, Ghilardi N, Li J, de Sauvage FJ. IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms. Proc Natl Acad Sci U S A 2003 Dec 9; 100(25): 15047-52. View Abstract on PubMed

  • Aggarwal S, Ghilardi N, Xie MH, de Sauvage FJ, Gurney AL. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem 2003 Jan 17; 278(3): 1910-4. View Abstract on PubMed

  • Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, Gurney A, Grewal IS, de Sauvage FJ. Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature 2000 Oct 19; 407(6806): 916-20. View Abstract on PubMed

  • Jingwu Xie, Maximilien Murone, Shiuh-Ming Luoh, Anne Ryan, Chaohui Zhang, Quimin Gu, Jeannette M. Bonifas, Ching-Wan Lam, Mary Hynes, Audrey Goddard, Xie Xie J, Murone M, Luoh SM, Ryan A, Gu Q, Zhang C, Bonifas JM, Lam CW, Hynes M, Goddard A, Rosenthal A, Epstein EH Jr, de Sauvage FJ. Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature 1998 Jan 1; 391(6662): 90-2. View Abstract on PubMed

  • Stone DM, Hynes M, Armanini M, Swanson TA, Gu Q, Johnson RL, Scott MP, Pennica D, Goddard A, Phillips H, Noll M, Hooper JE, de Sauvage F, Rosenthal A. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 1996 Nov 14; 384(6605): 129-34. View Abstract on PubMed

  • Fielder PJ, Gurney AL, Stefanich E, Marian M, Moore MW, Carver-Moore K, de Sauvage FJ. Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets. Blood 1996 Mar 15; 87(6): 2154-61. View Abstract on PubMed

  • de Sauvage FJ, Carver-Moore K, Luoh SM, Ryan A, Dowd M, Eaton DL, Moore MW. Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. J Exp Med 1996 Feb 1; 183(2): 651-6. View Abstract on PubMed

  • Gurney AL, Carver-Moore K, de Sauvage FJ, Moore MW. Thrombocytopenia in c-mpl-deficient mice. Science 1994 Sep 2; 265(5177): 1445-7. View Abstract on PubMed

  • de Sauvage FJ, Hass PE, Spencer SD, Malloy BE, Gurney AL, Spencer SA, Darbonne WC, Henzel WJ, Wong SC, Kuang WJ, Oles K, Hultgren B, Solber, L, Goeddel D, Eaton D. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 1994 Jun 16; 369(6481): 533-8. View Abstract on PubMed

  • de Sauvage F, Octave JN. A novel mRNA of the A4 amyloid precursor gene coding for a possibly secreted protein. Science 1989 Aug 11; 245(4918): 651-3. View Abstract on PubMed