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Morgan Sheng

Morgan Sheng
Morgan Sheng Vice President: Neuroscience

Profile | Education/Background | Top Scientific Papers | Awards & Honors

Top Scientific Papers

  • Seeburg DP, Sheng M. Activity-induced Polo-like kinase 2 is required for homeostatic plasticity of hippocampal neurons during epileptiform activity. J Neurosci 2008; 28(26): 6583-91. View Abstract on PubMed

  • Seeburg DP, Feliu-Mojer M, Gaiottino J, Pak DT, Sheng M. Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity. Neuron 2008; 58(4): 571-83. View Abstract on PubMed

  • Hung AH, Futai K, Sala C, Valtschanoff J, Ryu J, Woodworth M, Kidd FL, Sung CC, Miyakawa T, Bear MF, Weinberg FJ, Sheng M. Smaller Dendritic Spines, Weaker Synaptic Transmission but Enhanced Spatial Learning in Mice Lacking Shank1. J Neurosci 2008; 28(7): 1697-708. View Abstract on PubMed

  • Kim MJ, Futai K, Jo J, Hayashi Y, Cho K, Sheng M. Synaptic accumulation of PSD-95 and synaptic function regulated by phosphorylation of serine-295 of PSD-95. Neuron 2007; 56(3): 488-502. View Abstract on PubMed

  • Sheng M, Hoogenraad CC. The Postsynaptic Architecture of Excitatory Synapses: A More Quantitative View. Annu Rev Biochem 2007; 76: 823-47. View Abstract on PubMed

  • Ryu J, Liu L, Wong TP, Wu DC, Burette A, Weinberg R, Wang YT, Sheng M. A critical role for myosin IIb in dendritic spine morphology and synaptic function. Neuron 2006; 49(2): 175-82. View Abstract on PubMed

  • Kim MJ, Dunah AW, Wang YT, Sheng M. Differential roles of NR2A- and NR2B-containing NMDA receptors in Ras-ERK signaling and AMPA receptor trafficking. Neuron 2005; 46(5): 745-60. View Abstract on PubMed

  • Hoogenraad CC, Milstein AD, Ethell IM, Henkemeyer M, Sheng M. GRIP1 controls dendrite morphogenesis by regulating EphB receptor trafficking. Nat Neurosci 2005; 8(7): 906-15. View Abstract on PubMed

  • Nakagawa T, Cheng Y, Ramm E, Sheng M*, Walz T. Structure and different conformational states of native AMPA receptor complexes. Nature 2004; 433: 545-549. (* corresponding author). View Abstract on PubMed

  • Nakagawa T, Futai K, Lashuel HA, Lo I, Okamoto K, Walz T, Hayashi Y, Sheng M. Quaternary structure, protein dynamics, and synaptic function of SAP97 controlled by L27 domain interactions. Neuron 2004; 44: 453-67. View Abstract on PubMed

  • Lee SH, Simonetta A, Sheng M. Subunit rules governing the sorting of internalized AMPA receptors in hippocampal neurons. Neuron 2004; 43: 221-36. View Abstract on PubMed

  • Peng J, Kim MJ, Cheng D, Duong DM, Gygi SP, Sheng M. Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometry. J Biol Chem 2004; 279: 21003-11. View Abstract on PubMed

  • Li Z, Okamoto K, Hayashi Y, Sheng M. The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses. Cell 119: 873-87. View Abstract on PubMed

  • Pak DTS, Sheng M. (2003) Targeted Protein Degradation and Synapse Remodeling by an Inducible Protein Kinase. Science 2004; 302: 1368-73. View Abstract on PubMed

  • Passafaro M, Nakagawa T, Sala C, Sheng M. Induction of dendritic spines by an extracellular domain of AMPA receptor subunit GluR2. Nature 2003; 424: 677-681. View Abstract on PubMed

  • Lee SH, Liu L, Wang YT, Sheng M. Clathrin Adaptor AP2 and NSF Interact with Overlapping Sites of GluR2 and Play Distinct Roles in AMPA Receptor Trafficking and Hippocampal LTD. Neuron 2002; 36: 661-674. View Abstract on PubMed

  • Sala C, Piech V, Wilson NR, Passafaro M, Liu G, Sheng M. Regulation of dendritic spine morphology and synaptic function by shank and homer. Neuron 2001; 31: 115-130. View Abstract on PubMed

  • Lin JW, Ju W, Foster K, Lee, SH, Wang YT, Sheng M Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization. Nature Neurosci 2000; 3: 1282-1290. View Abstract on PubMed

  • Hsueh Y-P, Wang T-F, Yang F-C, Sheng M. Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2. Nature 2000; 404: 298-302. View Abstract on PubMed

  • Naisbitt S, Kim E, Tu JC, Xiao B, Sala C, Valtschanoff J, Weinberg RJ, Worley PF, Sheng M Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin. Neuron 1999; 23: 569-582. View Abstract on PubMed

  • Wyszynski M, Lin J, Rao A, Beggs A, Nigh E, Craig AM, Sheng M. Competitive binding of α-actinin and calmodulin to NMDA receptors. Nature 1997; 385: 439-442. View Abstract on PubMed

  • Doyle DA, Lee A, Lewis J, Kim E, Sheng M, MacKinnon R. Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. Cell 1996; 85: 1067-1076. View Abstract on PubMed

  • Kim E, Niethammer M, Rothschild A, Jan YN, Sheng M . Clustering of Shaker-type K+ channels by interaction with a family of membrane associated guanylate kinases. Nature 1995; 378: 85-88. View Abstract on PubMed

  • Sheng M, Cummings J, Roldan LA, Jan YN, Jan, LY . Changing subunit composition of heteromeric NMDA receptors during development of rat cortex. Nature 1994; 368, 144-147. View Abstract on PubMed