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Marc Tessier-Lavigne

Marc Tessier-Lavigne
Marc Tessier-Lavigne Executive Vice President: Research and Chief Scientific Officer

Profile | Education/Background | Top Scientific Papers | Awards & Honors

Top Scientific Papers

  • Steward O, Zheng B, Tessier-Lavigne M, Hofstadter M, Sharp K, Yee KM. Regenerative growth of corticospinal tract axons via the ventral column after spinal cord injury in mice. J Neurosci 2008 Jul 2; 28(27): 6836-47. View Abstract on PubMed

  • Ly A, Nikolaev A, Suresh G, Zheng Y, Tessier-Lavigne M, Stein E. DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1. Cell 2008 Jun 27; 133(7): 1241-54. View Abstract on PubMed

  • Di Meglio T, Nguyen-Ba-Charvet KT, Tessier-Lavigne M, Sotelo C, Chédotal A. Molecular mechanisms controlling midline crossing by precerebellar neurons. J Neurosci 2008 Jun 18; 28(25): 6285-94. View Abstract on PubMed

  • Bechara A, Nawabi H, Moret F, Yaron A, Weaver E, Bozon M, Abouzid K, Guan JL, Tessier-Lavigne M, Lemmon V, Castellani V. FAK-MAPK-dependent adhesion disassembly downstream of L1 contributes to semaphorin3A-induced collapse. EMBO J 2008 Jun 4; 27(11): 1549-62. Epub 2008 May 8. View Abstract on PubMed

  • Bouvrée K, Larrivée B, Lv X, Yuan L, DeLafarge B, Freitas C, Mathivet T, Bréant C, Tessier-Lavigne M, Bikfalvi A, Eichmann A, Pardanaud L. Netrin-1 inhibits sprouting angiogenesis in developing avian embryos. Dev Biol 2008 Jun 1; 318(1): 172-83. Epub 2008 Mar 26. View Abstract on PubMed

  • Powell AW, Sassa T, Wu Y, Tessier-Lavigne M, Polleux F. Topography of Thalamic Projections Requires Attractive and Repulsive Functions of Netrin-1 in the Ventral Telencephalon. PLoS Biol 2008 May 13; 6(5): e116. View Abstract on PubMed

  • Chen Z, Gore BB, Long H, Ma L, Tessier-Lavigne M. Alternative splicing of the Robo3 axon guidance receptor governs the midline switch from attraction to repulsion. Neuron 2008 May 8; 58(3): 325-32. View Abstract on PubMed

  • Caunt M, Mak J, Liang WC, Stawicki S, Pan Q, Tong RK, Kowalski J, Ho C, Reslan HB, Ross J, Berry L, Kasman I, Zlot C, Cheng Z, Le Couter J, Filvaroff EH, Plowman G, Peale F, French D, Carano R, Koch AW, Wu Y, Watts RJ, Tessier-Lavigne M, Bagri A. Blocking Neuropilin-2 Function Inhibits Tumor Cell Metastasis. Cancer Cell 2008 Apr; 13(4): 331-42. View Abstract on PubMed

  • Gore BB, Wong KG, Tessier-Lavigne M. Stem cell factor functions as an outgrowth-promoting factor to enable axon exit from the midline intermediate target. Neuron 2008 Feb 28; 57(4): 501-10. View Abstract on PubMed

  • Löw K, Culbertson M, Bradke F, Tessier-Lavigne M, Tuszynski MH. (2008) Netrin-1 is a novel myelin-associated inhibitor to axon growth. J Neurosci 2008 Jan 30; 28(5): 1099-108. View Abstract on PubMed

  • Hayhurst M, Gore BB, Tessier-Lavigne M, McConnell SK. Ongoing sonic hedgehog signaling is required for dorsal midline formation in the developing forebrain. Dev Neurobiol 2008 Jan; 68(1): 83-100. View Abstract on PubMed

  • Larrivée B, Freitas C, Trombe M, Lv X, Delafarge B, Yuan L, Bouvrée K, Bréant C, Del Toro R, Bréchot N, Germain S, Bono F, Dol F, Claes F, Fischer C, Autiero M, Thomas JL, Carmeliet P, Tessier-Lavigne M, Eichmann A. Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis. Genes Dev 2007 Oct 1; 21(19): 2433-47. View Abstract on PubMed

  • Hodge LK, Klassen MP, Han BX, Yiu G, Hurrell J, Howell A, Rousseau G, Lemaigre F, Tessier-Lavigne M, Wang F. Retrograde BMP signaling regulates trigeminal sensory neuron identities and the formation of precise face maps. Neuron 2007 Aug 16; 55(4): 572-86. View Abstract on PubMed

  • Dillon AK, Jevince AR, Hinck L, Ackerman SL, Lu X, Tessier-Lavigne M, Kaprielian Z. UNC5C is required for spinal accessory motor neuron development. Mol Cell Neurosci 2007 Jul; 35(3): 482-9. Epub 2007 May 6. View Abstract on PubMed

  • Chivatakarn O, Kaneko S, He Z, Tessier-Lavigne M, Giger RJ. The Nogo-66 receptor NgR1 is required only for the acute growth cone-collapsing but not the chronic growth-inhibitory actions of myelin inhibitors. J Neurosci 2007 Jul 4; 27(27): 7117-24. View Abstract on PubMed

  • Holst CR, Bou-Reslan H, Gore BB, Wong K, Grant D, Chalasani S, Carano RA, Frantz GD, Tessier-Lavigne M, Bolon B, French DM, Ashkenazi A. Secreted Sulfatases Sulf1 and Sulf2 Have Overlapping yet Essential Roles in Mouse Neonatal Survival. PLoS ONE 2007 Jun 27; 2(6): e575. View Abstract on PubMed

  • Ma L, Tessier-Lavigne M. Dual branch-promoting and branch-repelling actions of Slit/Robo signaling on peripheral and central branches of developing sensory axons. J Neurosci 2007 Jun 20; 27(25): 6843-51. View Abstract on PubMed

  • Matsumoto Y, Irie F, Inatani M, Tessier-Lavigne M, Yamaguchi Y. Netrin-1/DCC signaling in commissural axon guidance requires cell-autonomous expression of heparan sulfate. J Neurosci 2007 Apr 18; 27(16): 4342-50. View Abstract on PubMed

  • Friedel RH, Kerjan G, Rayburn H, Schuller U, Sotelo C, Tessier-Lavigne M, Chedotal A. Plexin-B2 controls the development of cerebellar granule cells. J Neurosci 2007 Apr 4; 27(14): 3921-32. View Abstract on PubMed

  • Lopez-Bendito G, Flames N, Ma L, Fouquet C, Di Meglio T, Chedotal A, Tessier-Lavigne M, Marin O. Robo1 and Robo2 cooperate to control the guidance of major axonal tracts in the mammalian forebrain. J Neurosci 2007 Mar 28; 27(13): 3395-407. View Abstract on PubMed

  • Fouquet C, Di Meglio T, Ma L, Kawasaki T, Long H, Hirata T, Tessier-Lavigne M, Chedotal A, Nguyen-Ba-Charvet KT. Robo1 and robo2 control the development of the lateral olfactory tract. J Neurosci 2007 Mar 14; 27(11): 3037-45. View Abstract on PubMed

  • Liang WC, Dennis MS, Stawicki S, Chanthery Y, Pan Q, Chen Y, Eigenbrot C, Yin J, Koch AW, Wu X, Ferrara N, Bagri A, Tessier-Lavigne M, Watts RJ, Wu Y. Function blocking antibodies to neuropilin-1 generated from a designed human synthetic antibody phage library. J Mol Biol 2007 Feb 23; 366(3): 815-29. Epub 2006 Nov 10. View Abstract on PubMed

  • Pan Q, Chanthery Y, Liang WC, Stawicki S, Mak J, Rathore N, Tong RK, Kowalski J, Yee SF, Pacheco G, Ross S, Cheng Z, Le Couter J, Plowman G, Peale F, Koch AW, Wu Y, Bagri A, Tessier-Lavigne M, Watts RJ. Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth. Cancer Cell 2007 Jan; 11(1): 53-67. View Abstract on PubMed

  • Okada A, Charron F, Morin S, Shin DS, Wong K, Fabre PJ, Tessier-Lavigne M, McConnell SK. Boc is a receptor for sonic hedgehog in the guidance of commissural axons. Nature 2006 Nov 16; 444(7117): 369-73. View Abstract on PubMed

  • Kennedy TE, Wang H, Marshall W, Tessier-Lavigne M. Axon guidance by diffusible chemoattractants: a gradient of netrin protein in the developing spinal cord. J Neurosci 2006 Aug 23; 26(34): 8866-74. View Abstract on PubMed

  • Chang C, Adler CE, Krause M, Clark SG, Gertler FB, Tessier-Lavigne M, Bargmann CI. MIG-10/lamellipodin and AGE-1/PI3K promote axon guidance and outgrowth in response to slit and netrin. Curr Biol 2006 May 9; 16(9): 854-62. View Abstract on PubMed

  • Friedel RH, Plump A, Lu X, Spilker K, Jolicoeur C, Wong K, Venkatesh TR, Yaron A, Hynes M, Chen B, Okada A, McConnell SK, Rayburn H, Tessier-Lavigne M. Gene targeting using a promoterless gene trap vector ("targeted trapping") is an efficient method to mutate a large fraction of genes. Proc Natl Acad Sci U S A 2005 Sep 13; 102(37): 13188-93. View Abstract on PubMed

  • Carmeliet P, Tessier-Lavigne M. Common mechanisms of nerve and blood vessel wiring. Nature 2005 Jul 14; 436(7048): 193-200. View Abstract on PubMed

  • Yaron A, Huang PH, Cheng HJ, Tessier-Lavigne M. Differential requirement for Plexin-A3 and -A4 in mediating responses of sensory and sympathetic neurons to distinct class 3 Semaphorins. Neuron 2005 Feb 17; 45(4): 513-23. View Abstract on PubMed

  • Zheng B, Atwal J, Ho C, Case L, He XL, Garcia KC, Steward O, Tessier-Lavigne M. Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. Proc Natl Acad Sci U S A 2005 Jan 25; 102(4): 1205-10. View Abstract on PubMed

  • Lu X, Le Noble F, Yuan L, Jiang Q, De Lafarge B, Sugiyama D, Breant C, Claes F, De Smet F, Thomas JL, Autiero M, Carmeliet P, Tessier-Lavigne M, Eichmann A. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature 2004 Nov 11; 432(7014): 179-86. View Abstract on PubMed

  • Chang C, Yu TW, Bargmann CI, Tessier-Lavigne M. Inhibition of netrin-mediated axon attraction by a receptor protein tyrosine phosphatase. Science 2004 Jul 2; 305(5680): 103-6. View Abstract on PubMed

  • Lu X, Borchers AG, Jolicoeur C, Rayburn H, Baker JC, Tessier-Lavigne M. PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates. Nature 2004 Jul 1; 430(6995): 93-8. View Abstract on PubMed

  • Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M. The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons. Cell 2004 Apr 16; 117(2): 157-69. View Abstract on PubMed

  • Colavita A, Tessier-Lavigne M. A Neurexin-related protein, BAM-2, terminates axonal branches in C. elegans. Science 2003 Oct 10; 302(5643): 293-6. View Abstract on PubMed

  • Bagri A, Cheng HJ, Yaron A, Pleasure SJ, Tessier-Lavigne M. Stereotyped pruning of long hippocampal axon branches triggered by retraction inducers of the semaphorin family. Cell 2003 May 2; 113(3): 285-99. View Abstract on PubMed

  • Charron F, Stein E, Jeong J, McMahon AP, Tessier-Lavigne M. The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell 2003 Apr 4; 113(1): 11-23. View Abstract on PubMed

  • Stein E, Tessier-Lavigne M. Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex. Science 2001 Mar 9; 291(5510): 1928-38. View Abstract on PubMed

  • Stein E, Zou Y, Poo M, Tessier-Lavigne M. Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation. Science 2001 Mar 9; 291(5510): 1976-82. View Abstract on PubMed

  • Leighton PA, Mitchell KJ, Goodrich LV, Lu X, Pinson K, Scherz P, Skarnes WC, Tessier-Lavigne M. Defining brain wiring patterns and mechanisms through gene trapping in mice. Nature 2001 Mar 8; 410(6825): 174-9. View Abstract on PubMed

  • Galko MJ, Tessier-Lavigne M. Function of an axonal chemoattractant modulated by metalloprotease activity. Science 2000 Aug 25; 289(5483): 1365-7. View Abstract on PubMed

  • Zou Y, Stoeckli E, Chen H, Tessier-Lavigne M. Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord. Cell 2000 Aug 4; 102(3): 363-75. View Abstract on PubMed

  • Wang H, Tessier-Lavigne M. En passant neurotrophic action of an intermediate axonal target in the developing mammalian CNS. Nature 1999 Oct 21; 401(6755): 765-9. View Abstract on PubMed

  • Wang KH, Brose K, Arnott D, Kidd T, Goodman CS, Henzel W, Tessier-Lavigne M. Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching. Cell 1999 Mar 19; 96(6): 771-84. View Abstract on PubMed

  • He Z, Tessier-Lavigne M. Neuropilin is a receptor for the axonal chemorepellent Semaphorin III. Cell 1997 Aug 22; 90(4): 739-51. View Abstract on PubMed

  • Leonardo ED, Hinck L, Masu M, Keino-Masu K, Ackerman SL, Tessier-Lavigne M. Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors. Nature 1997 Apr 24; 386(6627): 833-8. View Abstract on PubMed

  • Serafini T, Colamarino SA, Leonardo ED, Wang H, Beddington R, Skarnes WC, Tessier-Lavigne M. Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell 1996 Dec 13; 87(6): 1001-14. View Abstract on PubMed

  • Keino-Masu K, Masu M, Hinck L, Leonardo ED, Chan SS, Culotti JG, Tessier-Lavigne M. Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. Cell 1996 Oct 18; 87(2): 175-85. View Abstract on PubMed

  • Colamarino SA, Tessier-Lavigne M. The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons. Cell 1995 May 19; 81(4): 621-9. View Abstract on PubMed

  • Fan CM, Porter JA, Chiang C, Chang DT, Beachy PA, Tessier-Lavigne M. Long-range sclerotome induction by sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway. Cell 1995 May 5; 81(3): 457-65. View Abstract on PubMed

  • Fan CM, Tessier-Lavigne M. Patterning of mammalian somites by surface ectoderm and notochord: evidence for sclerotome induction by a hedgehog homolog. Cell 1994 Dec 30; 79(7): 1175-86. View Abstract on PubMed

  • Kennedy TE, Serafini T, de la Torre JR, Tessier-Lavigne M. Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Cell 1994 Aug 12; 78(3): 425-35. View Abstract on PubMed

  • Serafini T, Kennedy TE, Galko MJ, Mirzayan C, Jessell TM, Tessier-Lavigne M. The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell 1994 Aug 12; 78(3): 409-24. View Abstract on PubMed