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John Lowe

John Lowe
John Lowe Senior Director: Pathology

Profile | Education/Background | Top Scientific Papers | Awards & Honors

Top Scientific Papers

  • Zhou L, Li LW, Yan Q, Petryniak B, Man Y, Su C, Shim J, Chervin S, Lowe JB. Notch-dependent control of myelopoiesis is regulated by fucosylation. Blood 2008 Mar 21; [Epub ahead of press] View Abstract on PubMed

  • Mitoma J, Bao X, Petryanik B, Schaerli P, Gauguet JM, Yu SY, Kawashima H, Saito H, Ohtsubo K, Marth JD, Khoo KH, von Andrian UH, Lowe JB, Fukuda M. Critical functions of N-glycans in L-selectin-mediated lymphocyte homing and recruitment. Nat Immunol 2007 Apr; 8(4): 409-18. View Abstract on PubMed

  • Kawashima H, Petryniak P, Hiraoka N, Mitoma J, Huckaby V, Nakayama J, Uchimura K, Kadomatsu K, Muramatsu T, Lowe JB, Fukuda M. N-acetylglucosamine-6-O-sulfotransferase 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules. Nat Immunol 2005 Nov; 6(11): 1096-104. View Abstract on PubMed

  • Haltiwanger RS, Lowe JB. Role of glycosylation in development. Annu Rev Biochem 2004; 73: 491-537. View Abstract on PubMed

  • Becker DJ, Myers JT, Ruff MM, Smith PL, Gillespie BW, Ginsburg DW, Lowe JB. Strain-specific modification of lethality in fucose-deficient mice. Mamm Genome 2003 Feb; 14(2): 130-9. View Abstract on PubMed

  • Lowe JB, Marth JD. A genetic approach to Mammalian glycan function. Annu Rev Biochem 2003; 72: 643-91. View Abstract on PubMed

  • Smith PL, Myers JT, Rogers CE, Zhou L, Petryniak B, Becker DJ, Homeister JW, Lowe JB. Conditional control of selectin ligand expression and global fucosylation events in mice with a targeted mutation at the FX locus. J Cell Biol 2002 Aug 19; 158(4): 801-15. View Abstract on PubMed

  • Smithson G, Rogers CE, Smith PL, Scheidegger EP, Petryniak B, Myers JT, Kim DS, Homeister JW, Lowe JB. Fuc-TVII is required for Th1 and Tc1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naïve T cell trafficking to lymph nodes. J Exp Med 2001 Sep 3; 194(5): 601-14. View Abstract on PubMed

  • Homeister JW, Thall AD, Petryniak B, Maly P, Rogers CE, Smith PL, Kelly RJ, Gersten KM, Askari SW, Cheng G, Smithson G, Marks RM, Misra AK, Hindsgaul O, von Andrian UH, Lowe JB. The (1,3)fucosyltransferases Fuc-TIV and Fuc-TVII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing. Immunity 2001 Jul; 15(1): 115-26. View Abstract on PubMed

  • Lowe JB. Glycosylation, immunity, and autoimmunity. Cell 2001 Mar 23; 104(6): 809-12. View Abstract on PubMed

  • Weninger W, Ulfman LH, Cheng G, Souchkova N, Quackenbush EJ, Lowe JB, von Andrian UH. Specialized contributions by alpha(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels. Immunity 2000 Jun; 12(6): 665-76. View Abstract on PubMed

  • Hiraoka N, Petryniak B, Nakayama J, Tsuboi S, Suzuki M, Yeh JC, Izawa D, Tanaka T, Miyasaka M, Lowe JB, Fukuda M. A novel, high endothelial venule-specific sulfotransferase expresses of 6-sulfo sialyl Lewis(x), an L-selectin ligand displayed by CD34. Immunity 1999 Jul; 11(1): 79-89. View Abstract on PubMed

  • Mohlke KL, Purkayastha AA, Westrick RJ, Smith PL, Petryniak B, Lowe JB, Ginsburg D. Mvwf, a dominant modifier of murine von Willebrand factor, results from altered lineage-specific expression of a glycosyltransferase. Cell 1999 Jan 8; 96(1): 111-120. View Abstract on PubMed

  • Lowe JB, Ward PA. Therapeutic inhibition of carbohydrate-protein interactions in vivo. J Clin Invest 1997 Mar 1; 99(5): 822-6. View Abstract on PubMed

  • Maly P, Thall AD, Petryniak B, Rogers CE, Smith PL, Marks RM, Kelly RJ, Gersten KM, Cheng G, Saunders TL, Camper SA, Camphausen RT, Sullivan FX, Isogai Y, Hindsgaul O, von Adrian UH, Lowe JB. The (1,3)fucosyltransferase Fuc TVII controls leukocyte trafficking through an essential role in L-, E-, and P selectin ligand biosynthesis. Cell 1996 Aug 23; 86(4): 643-53. View Abstract on PubMed

  • Kelly RJ, Rouquier S, Giorgi D, Lennon GG, Lowe JB. Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype. J Biol Chem 1995 Mar 3; 270(9): 4640-9. View Abstract on PubMed

  • Rouquier S, Lowe JB, Kelly RJ, Fertitta AL, Lennon GG, Giorgi D. Molecular cloning of a human genomic region containing the H blood group alpha(1,2)fucosyltransferase gene and two H locus-related DNA restriction fragments. Isolation of a candidate for the human Secretor blood group locus. J Biol Chem 1995 Mar 3; 270(9): 4632-9. View Abstract on PubMed

  • Kelly RJ, Ernst LK, Larsen RD, Bryant JG, Robinson JS, and Lowe JB. Molecular basis for H blood group deficiency in Bombay (Oh) and para-Bombay individuals. Proc Natl Acad Sci USA 1994 Jun 21; 91(13): 5843-7. View Abstract on PubMed

  • Weston BW, Nair RP, Larsen RD, Lowe JB. Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities. J Biol Chem 1992 Feb 25; 267(6): 4152-60. View Abstract on PubMed

  • Ball GE, O'Neill R, Schultz JE, Lowe JB, Weston BW, Nagy JO, Brown EG, Hobbs C, Bednarski MD. Synthesis and structural analysis using 2-D NMR of sialyl Lewis X (SLex) and Lewis X (Lex) oligosaccharides: ligands related to E-selectin (ELAM-1) binding. J Am Chem Soc 1992; 114: 5449-51. View Abstract on PubMed

  • Wong CH, Dumas DP, Ichikawa Y, Koseki K, Danishefsky SJ, Weston BW, Lowe JB. Specificity, inhibition and synthetic utility of a recombinant human alpha (1,3)fucosyltransferase. J Am Chem Soc 1992; 114: 7321-22. View Abstract on PubMed

  • Lowe JB, Stoolman LM, Nair RP, Larsen RD, Berhend TL, Marks RM. ELAM-1-dependent cell adhesion to vascular endothelium determined by a transfected human fucosyltransferase cDNA. Cell 1990 Nov 2; 63(3): 475-84. View Abstract on PubMed

  • Larsen RD, Ernst LK, Rajan VP, Lowe JB. Molecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen. Proc Natl Acad Sci USA 1990 Sep; 87(17): 6674-8. View Abstract on PubMed

  • Kukowska-Latallo JF, Larsen RD, Nair RP, Lowe JB. A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase. Genes Dev 1990 Aug; 4(8): 1288-303. View Abstract on PubMed

  • Larsen RD, Rajan VP, Ruff MM, Kukowska-Latallo J, Cummings RD, Lowe JB. Isolation of a cDNA encoding a murine UDPgalactose:beta-D-galactosyl- 1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase: expression cloning by gene transfer. Proc Natl Acad Sci USA 1989 Nov; 86(21): 8227-31. View Abstract on PubMed

  • Rajan VP, Larsen RD, Ajmera S, Ernst LK, Lowe JB. A cloned human DNA restriction fragment determines expression of a GDP-L-fucose: beta-D-galactoside 2-alpha-L-fucosyltransferase in transfected cells. Evidence for isolation and transfer of the human H blood group locus. J Biol Chem 1989 Jul 5; 264(19): 11158-67. View Abstract on PubMed

  • Lowe JB, Berg DE. A product of the Tn5 transposase gene inhibits transposition. Genetics 1983 Apr; 103(4): 605-15. View Abstract on PubMed

  • Berg DE, Egner C, Lowe JB. Mechanism of F factor-enhanced excision of transposon Tn5. Gene 1983 Apr; 22(1): 1-7. View Abstract on PubMed

  • Berg DE, Schmandt MA, Lowe JB. Specificity of transposon Tn5 insertion. Genetics 1983 Dec; 105(4): 813-28. View Abstract on PubMed