Skip to Content for Vishva Dixit Menu for Vishva Dixit About Us Menu Research Menu Development Menu Medicines Menu Investors Menu Media Menu Careers Menu
Banner Image

Vishva Dixit

Vishva Dixit
Vishva Dixit Vice President: Physiological Chemistry

Profile | Education/Background | Top Scientific Papers | Awards & Honors

Top Scientific Papers

  • Kayagaki N, Phung Q, Chan S, Chaudhari R, Quan C, O'Rourke KM, Eby M, Pietras E, Cheng G, Bazan JF, Zhang Z, Arnott D, Dixit VM. DUBA: a deubiquitinase that regulates type I interferon production. Science 2007 Dec 7; 318(5856): 1628-32. Epub 2007 Nov 8. View Abstract on PubMed

  • Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, Garg P, Zobel K, Dynek JN, Elliott LO, Wallweber HJ, Flygare JA, Fairbrother WJ, Deshayes K, Dixit VM, Vucic D. IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell 2007 Nov 16; 131(4): 669-81. View Abstract on PubMed

  • Dornan D, Shimizu H, Mah A, Dudhela T, Eby M, O'rourke K, Seshagiri S, Dixit VM. ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage. Science 2006 Aug 25; 313(5790): 1122-6. View Abstract on PubMed

  • Mariathasan S, Weiss DS, Newton K, McBride J, O'Rourke K, Roose-Girma M, Lee WP, Weinrauch Y, Monack DM, Dixit VM. Cryopyrin activates the inflammasome in response to toxins and ATP.1: Nature 2006 Mar 9; 440(7081): 228-32. View Abstract on PubMed

  • Zhou H, Du MQ, Dixit VM. Constitutive NF-kappaB activation by the t(11; 18)(q21; q21) product in MALT lymphoma is linked to deregulated ubiquitin ligase activity. Cancer Cell 2005 May; 7(5): 425-31. View Abstract on PubMed

  • Wertz IE, O'Rourke KM, Zhou H, Eby M, Aravind L, Seshagiri S, Wu P, Wiesmann C, Baker R, Boone DL, Ma A, Koonin EV, Dixit VM. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature 2004 Aug 5; 430(7000): 694-9. View Abstract on PubMed

  • Mariathasan S, Newton K, Monack DM, Vucic D, French DM, Lee WP, Roose-Girma M, Erickson S, Dixit VM. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 2004 Jul 8; 430(6996): 213-8. View Abstract on PubMed

  • Dornan D, Wertz I, Shimizu H, Arnott D, Frantz GD, Dowd P, O'Rourke K, Koeppen H, Dixit VM. The ubiquitin ligase COP1 is a critical negative regulator of p53. Nature 2004 May 6; 429(6987): 86-92. View Abstract on PubMed

  • Wertz IE, O'Rourke KM, Zhang Z, Dornan D, Arnott D, Deshaies RJ, Dixit VM. Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. Science 2004 Feb 27; 303(5662): 1371-4. View Abstract on PubMed

  • Zhou H, Wertz I, O'Rourke K, Ultsch M, Seshagiri S, Eby M, Xiao W, Dixit VM. Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO. Nature 2004 Jan 8; 427(6970): 167-71. View Abstract on PubMed

  • Ruefli-Brasse AA, French DM, Dixit VM. Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase. Science 2003 Nov 28; 302(5650): 1581-4. View Abstract on PubMed

  • Kayagaki N, Yan M, Seshasayee D, Wang H, Lee W, French DM, Grewal IS, Cochran AG, Gordon NC, Yin J, Starovasnik MA, Dixit VM. BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2. Immunity 2002 Oct; 17(4): 515-24. View Abstract on PubMed

  • Yan M, Wang H, Chan B, Roose-Girma M, Erickson S, Baker T, Tumas D, Grewal IS, Dixit VM. Activation and accumulation of B cells in TACI-deficient mice. Nat Immunol 2001 Jul; 2(7): 638-43. View Abstract on PubMed

  • Yan M, Marsters SA, Grewal IS, Wang H, Ashkenazi A, Dixit VM. Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity. Nat Immunol 2000 Jul; 1(1): 37-41. View Abstract on PubMed

  • Yan M, Wang LC, Hymowitz SG, Schilbach S, Lee J, Goddard A, de Vos AM, Gao WQ, Dixit VM. Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. Science 2000 Oct 20; 290(5491): 523-7. View Abstract on PubMed

  • Humke EW, Shriver SK, Starovasnik MA, Fairbrother WJ, Dixit V.M. ICEBERG: a novel inhibitor of interleukin-1beta generation. Cell 2000 Sep 29; 103(1): 99-111. View Abstract on PubMed

  • Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science 1998 Aug 28; 281(5381): 1305-8. View Abstract on PubMed

  • Muzio M, Ni J, Feng P, Dixit VM. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 1997 Nov 28; 278(5343): 1612-5. View Abstract on PubMed

  • Salvesen GS, Dixit VM. Caspases: intracellular signaling by proteolysis. Cell 1997 Nov 14; 91(4): 443-6. View Abstract on PubMed

  • Chinnaiyan AM, Chaudhary D, O'Rourke K, Koonin EV, Dixit VM. Role of CED-4 in the activation of CED-3. Nature 1997 Aug 21; 388(6644): 728-9. View Abstract on PubMed

  • Pan G, Ni J, Wei YF, Yu G, Gentz R, Dixit VM. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 1997 Aug 8; 277(5327): 815-8. View Abstract on PubMed

  • Pan G, O'Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J, Dixit VM. The receptor for the cytotoxic ligand TRAIL. Science 1997 Apr 4; 276(5309): 111-3. View Abstract on PubMed

  • Chinnaiyan AM, O'Rourke K, Lane BR, Dixit VM. Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death. Science 1997 Feb 21; 275(5303): 1122-6. View Abstract on PubMed

  • Duan H, Dixit VM. RAIDD is a new 'death' adaptor molecule. Nature 1997 Jan 2; 385(6611): 86-9. View Abstract on PubMed

  • Chinnaiyan AM, O'Rourke K, Yu GL, Lyons RH, Garg M, Duan DR, Xing L, Gentz R, Ni J, Dixit VM. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science 1996 Nov 8; 274(5289): 990-2. View Abstract on PubMed

  • * Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R, Mann M, Krammer PH, Peter ME, Dixit VM. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex. Cell 1996 Jun 14; 85(6): 817-27. View Abstract on PubMed

  • * Duan H, Chinnaiyan AM, Hudson PL, Wing JP, He WW, Dixit VM. ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis. J Biol Chem 1996 Jan 19; 271(3): 1621-5. View Abstract on PubMed

  • * Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen GS, Dixit VM. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 1995 Jun 2; 81(5): 801-9. View Abstract on PubMed

  • Chinnaiyan AM, O 'Rourke K, Tewari M, Dixit VM. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 1995 May 19; 81(4): 505-12. View Abstract on PubMed

  • Pandey A, Shao H, Marks RM, Polverini PJ, Dixit VM. Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis. Science 1995 Apr 28; 268(5210): 567-9. View Abstract on PubMed

  • * Tewari M, Dixit VM. Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. Biol Chem 1995 Feb 17; 270(7): 3255-60. View Abstract on PubMed

* Indicates designation as a "hot paper" by The Scientist