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Richard H. Scheller

Richard H. Scheller
Richard H. Scheller Executive Vice President: Genentech Research & Early Development

Profile | Education/Background | Top Scientific Papers | Awards & Honors

Top Scientific Papers

  • Westlake CJ, Junutula JR, Simon GC, Pilli M, Prekeris R, Scheller RH, Jackson PK, Eldridge AG. Identification of Rab11 as a small GTPasebinding protein for the Evi5 oncogene. Proc Natl Acad Sci U S A 2007 Jan 23; 104(4): 1236-41. View Abstract on PubMed

  • Jahn R, Scheller RH. SNAREs--engines for membrane fusion. Nat Rev Mol Cell Biol 2006 Sep; 7(9): 631-43. View Abstract on PubMed

  • Austin CD, Lawrence DA, Peden AA, Varfolomeev EE, Totpal K, De Maziere AM, Klumperman J, Arnott D, Pham V, Scheller RH, Ashkenazi A. Death-receptor activation halts clathrin-dependent endocytosis. Proc Natl Acad Sci U S A 2006 Jul 5; 103(27): 10283-8. View Abstract on PubMed

  • Jin R, Junutula JR, Matern HT, Ervin KE, Scheller RH, Brunger AT. Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase. EMBO J 2005 Jun 15; 24(12): 2064-74. View Abstract on PubMed

  • Junutula JR, De Maziere AM, Peden AA, Ervin KE, Advani RJ, van Dijk SM, Klumperman J, Scheller RH. Rab14 is involved in membrane trafficking between the Golgi complex and endosomes. Mol Biol Cell 2004 May; 15(5): 2218-29. View Abstract on PubMed

  • Peden AA, Oorschot V, Hesser BA, Austin CD, Scheller RH, Klumperman J. Localization of the AP-3 adaptor complex defines a novel endosomal exit site for lysosomal membrane proteins. J Cell Biol 2004 Mar 29; 164(7): 1065-76. View Abstract on PubMed

  • Smith SM, Bergsman JB, Harata NC, Scheller RH, Tsien RW. Recordings from single neocortical nerve terminals reveal a nonselective cation channel activated by decreases in extracellular calcium. Neuron 2004 Jan 22; 41(2): 243-56. View Abstract on PubMed

  • Scales SJ, Yoo BY, Scheller RH. The ionic layer is required for efficient dissociation of the SNARE complex by alpha-SNAP and NSF. Proc Natl Acad Sci U S A 2001 Dec 4; 98(25): 14262-7. View Abstract on PubMed

  • Chen YA, Scales SJ, Scheller RH. Sequential SNARE assembly underlies priming and triggering of exocytosis. Neuron 2001 Apr; 30(1): 161-70. View Abstract on PubMed

  • Bock JB, Matern HT, Peden AA, Scheller RH. A genomic perspective on membrane compartment organization. Nature 2001 Feb 15; 409(6822): 839-41. View Abstract on PubMed

  • Prekeris R, Klumperman J, Scheller RH. A Rab11/Rip11 protein complex regulates apical membrane trafficking via recycling endosomes. Mol Cell 2000 Dec; 6(6): 1437-48. View Abstract on PubMed

  • Scales SJ, Chen YA, Yoo BY, Patel SM, Doung YC, Scheller RH. SNAREs contribute to the specificity of membrane fusion. Neuron 2000 May; 26(2): 457-64. View Abstract on PubMed

  • Misura KM, Scheller RH, Weis WI. Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex. Nature 2000 Mar 23; 404(6776): 355-62. View Abstract on PubMed

  • Chen YA, Scales SJ, Patel SM, Doung YC, Scheller RH. SNARE complex formation is triggered by Ca2+ and drives membrane fusion. Cell 1999 Apr 16; 97(2): 165-74. View Abstract on PubMed

  • Hay JC, Chao DS, Kuo CS, Scheller RH. Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. Cell 1997 Apr 4; 89(1): 149-58. View Abstract on PubMed

  • Malgaroli A, Ting AE, Wendland B, Bergamaschi A, Villa A, Tsien RW, Scheller RH. Presynaptic component of long-term potentiation visualized at individual hippocampal synapses. Science 1995 Jun 16; 268(5217): 1624-8. View Abstract on PubMed

  • Shear JB, Fishman HA, Allbritton NL, Garigan D, Zare RN, Scheller RH. Single cells as biosensors for chemical separations. Science 1995 Jan 6; 267(5194): 74-7. View Abstract on PubMed

  • Campanelli JT, Roberds SL, Campbell KP, Scheller RH. A role for dystrophin-associated glycoproteins and utrophin in agrin-induced AChR clustering. Cell 1994 Jun 3; 77(5): 663-74. View Abstract on PubMed

  • Calakos N, Bennett MK, Peterson KE, Scheller RH. Protein-protein interactions contributing to the specificity of intracellular vesicular trafficking. Science 1994 Feb 25; 263(5150): 1146-9. View Abstract on PubMed