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Lori Friedman

Lori Friedman
Lori Friedman Director: Cancer Signaling & Translational Oncology

Profile | Education/Background | Top Scientific Papers | Awards & Honors

Top Scientific Papers

  • Folkes AJ, Ahmadi K, Alderton WK, Alix S, Saker SJ, Box G, Chuckowree IS, Clark PA, Depledge P, Eccles SA, Friedman LS, Hayes A, Hancox TC, Kugendrades A, Lensun L, Moore P, Olivero AG, Pang J, Patel S, Pergl-Wilson GH, Raynaud FL, Robson A, Saghir N, Salphati, Sohal S, Ultasch MH, Valenti M, Wallweber HJ, Wan NC, Wiesmann C, Workman P, Zhyyoloup A, Zyelebil MJ, Shuttleworth SJ. The identification of 2-(1H-Indazol-4-yl)-6-(4-
    methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 Kinase for the treatment of cancer. J Med Chem 2008 Aug 29; EPUB ahead of Print. View Abstract on PubMed

  • Edgar KA, Belvin M, Parks AL, Whittaker K, Mahoney MB, Nicoll M, Park CC, Winter CG, Chen F, Lickteig K, Ahmad F, Esengil H, Lorenzi MV, Norton A, Rupnow BA, Shayesteh L, Tabios M, Young LM, Carroll PM, Kopczynski C, Plowman GD, Friedman LS, Francis-Lang HL. Synthetic lethality of retinoblastoma mutant cells in the Drosophila eye by mutation of a novel peptidyl prolyl isomerase gene. Genetics 2005 May; 170(1): 161-71. View Abstract on PubMed

  • Parks AL, Cook KR, Belvin M, Dompe NA, Fawcett R, Huppert K, Tan LR, Winter CG, Bogart KP, Deal JE, Deal-Herr ME, Grant D, Marcinko M, Miyazaki WY, Robertson S, Shaw KJ, Tabios M, Vysotskaia V, Zhao L, Andrade RS, Edgar KA, Howie E, Killpack K, Milash B, Norton A, Thao D, Whittaker K, Winner MA, Friedman L, Margolis J, Singer MA, Kopczynski C, Curtis D, Kaufman TC, Plowman GD, Duyk G, Francis-Lang HL. Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome. Nat Genet 2004 Mar; 36(3): 288-92. View Abstract on PubMed

  • Ollmann M, Young LM, Di Como CJ, Karim F, Belvin M, Robertson S, Whittaker K, Demsky M, Fisher WW, Buchman A, Duyk G, Friedman L, Prives C, Kopczynski C. Drosophila p53 is a structural and functional homolog of the tumor suppressor p53. Cell 2000 Mar 31; 101(1): 91-101. View Abstract on PubMed

  • Ramus SJ, Bobrow LG, Pharoah PD, Finnigan DS, Fishman A, Altaras M, Harrington PA, Gayther SA, Ponder BA, Friedman LS. Increased frequency of TP53 mutations in BRCA1 and BRCA2 ovarian tumours. Genes Chromosomes Cancer 1999 Jun; 25(2): 91-6. View Abstract on PubMed

  • Lee H, Trainer AH, Friedman LS, Thistlethwaite FC, Evans MJ, Ponder BA, Venkitaraman AR. Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2. Mol Cell 1999 Jul; 4(1): 1-10. View Abstract on PubMed

  • Friedman LS, Thistlethwaite FC, Patel KJ, Yu VP, Lee H, Venkitaraman AR, Abel KJ, Carlton MB, Hunter SM, Colledge WH, Evans MJ, Ponder BA. Thymic lymphomas in mice with a truncating mutation in Brca2. Cancer Res 1998 Apr 1; 58(7): 1338-43. View Abstract on PubMed

  • Patel KJ, Yu VP, Lee H, Corcoran A, Thistlethwaite FC, Evans MJ, Colledge WH, Friedman LS, Ponder BA, Venkitaraman AR. Involvement of Brca2 in DNA repair. Mol Cell 1998 Feb; 1(3): 347-57. View Abstract on PubMed

  • Friedman LS, Szabo CI, Ostermeyer EA, Dowd P, Butler L, Park T, Lee MK, Goode EL, Rowell SE, King MC. Novel inherited mutations and variable expressivity of BRCA1 alleles, including the founder mutation 185delAG in Ashkenazi Jewish families. Am J Hum Genet 1995 Dec; 57(6): 1284-97. View Abstract on PubMed

  • Shattuck-Eidens D, McClure M, Simard J, Labrie F, Narod S, Couch F, Hoskins K, Weber B, Castilla L, Erdos M, et al. A collaborative survey of 80 mutations in the BRCA1 breast and ovarian cancer susceptibility gene. Implications for presymptomatic testing and screening. JAMA 1995 Feb 15; 273(7): 535-41. View Abstract on PubMed

  • Friedman LS, Ostermeyer EA, Szabo CI, Dowd P, Lynch ED, Rowell SE, King MC. Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families. Nat Genet 1994 Dec; 8(4): 399-404. View Abstract on PubMed