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Mike Costa

Mike Costa
Mike Costa Senior Sceintist: Cancer Targets

Profile | Education/Background | Top Scientific Papers | Awards & Honors

Top Scientific Papers

  • Bourhis E, Tam C, Franke Y, Bazan JF, Ernst J, Hwang J, Costa M, Cochran AG, Hannoush RN. Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6. J Biol Chem 2010 Mar 19; 285(12): 9172-9. View Abstract on PubMed

  • Junge HJ, Yang S, Burton JB, Paes K, Shu X, French DM, Costa M, Rice DS, Ye W. TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4/beta-catenin signaling. Cell 2009 Oct 16; 139(2): 299-311. View Abstract on PubMed

  • Zhang Y, Appleton BA, Wiesmann C, Lau T, Costa M, Hannoush RN, Sidhu SS. Inhibition of Wnt signaling by Dishevelled PDZ peptides. Nat Chem Biol. 2009 Apr; 5(4): 217-9. View Abstract on PubMed

  • Morrell NT, Leucht P, Zhao L, Kim JB, ten Berge D, Ponnusamy K, Carre AL, Dudek H, Zachlederova M, McElhaney M, Brunton S, Gunzner J, Callow M, Polakis P, Costa M, Zhang XM, Helms JA, Nusse R. Liposomal packaging generates Wnt protein with in vivo biological activity. PLoS One 2008 Aug 13; 3(8): e2930. View Abstract on PubMed

  • Lackner MR, Kindt RM, Carroll PM, Brown K, Cancilla MR, Chen C, de Silva H, Franke Y, Guan B, Heuer T, Hung T, Keegan K, Lee JM, Manne V, O'Brien C, Parry D, Perez-Villar JJ, Reddy RK, Xiao H, Zhan H, Cockett M, Plowman G, Fitzgerald K, Costa M, Ross-Macdonald P. Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors. Cancer Cell 2005 Apr ;7(4): 325-36. View Abstract on PubMed

  • Pierce SB, Costa M, Wisotzkey R, Devadhar S, Homburger SA, Buchman AR, Ferguson KC, Heller J, Platt DM, Pasquinelli AA, Liu LX, Doberstein SK, Ruvkun G. Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev 2001 Mar 15; 15(6): 672-86. View Abstract on PubMed

  • Costa M, Raich W, Agbunag C, Leung B, Hardin J, Priess JR. A putative catenin-cadherin system mediates morphogenesis of the Caenorhabditis elegans embryo. J Cell Biol 1998 Apr 6; 141(1): 297-308. View Abstract on PubMed

  • Morize P, Christiansen AE, Costa M, Parks S, Wieschaus E. Hyperactivation of the folded gastrulation pathway induces specific cell shape changes. Development 1998 Feb; 125(4): 589-97. View Abstract on PubMed

  • Kenyon CJ, Austin J, Costa M, Cowing DW, Harris JM, Honigberg L, Hunter CP, Maloof JN, Muller-Immerglück MM, Salser SJ, Waring DA, Wang BB, Wrischnik LA. The dance of the Hox genes: patterning the anteroposterior body axis of Caenorhabditis elegans. Cold Spring Harb Symp Quant Biol 1997; 62: 293-305. View Abstract on PubMed

  • Costa M, Wilson ET, Wieschaus E. A putative cell signal encoded by the folded gastrulation gene coordinates cell shape changes during Drosophila gastrulation. Cell 1994 Mar 25; 76(6): 1075-89. View Abstract on PubMed

  • Costa M, Sweeton D, Wieschaus E. Gastrulation in Drosophila: cellular mechanisms of morphogenetic movements. In: Bate M, Martinez-Arias A, editors. The development of Drosophila melanogaster Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press; 1993. p. 425-66.

  • Wieschaus E, Parks S, Costa M, Sweeton D. (1991). Genes controlling cell shape changes during gastrulation in Drosophila melanogaster In: Gerhart J, editor. Cell-cell interactions in early development. New York: Wiley-Liss; 1991.

  • Wieschaus E, Sweeton D, Costa M. Convergence and extension during germ band elongation in Drosophila embryos. In: Keller R, Clark W Jr, Griffini F, editors. Gastrulation: movements, patterns, and molecules. New York: Plenum Press; 1991. p. 213-23.

  • Sweeton D, Parks S, Costa M, Wieschaus E. Gastrulation in Drosophila: the formation of the ventral furrow and posterior midgut invaginations. Development 1991 Jul; 112(3): 775-89. View Abstract on PubMed

  • Costa M, Weir M, Coulson A, Sulston J, Kenyon C. Posterior pattern formation in C. elegans involves position-specific expression of a gene containing a homeobox. Cell 1988 Dec 2; 55(5): 747-56. View Abstract on PubMed