Skip to Content for Paul Polakis Menu for Paul Polakis About Us Menu Research Menu Development Menu Medicines Menu Investors Menu Media Menu Careers Menu
Banner Image

Paul Polakis

Paul Polakis
Paul Polakis Director, Staff Scientist: Cancer Targets

Profile | Education/Background | Top Scientific Papers

Top Scientific Papers

  • Dealmeida VI, Miao L, Ernst JA, Koeppen H, Polakis P, Rubinfeld B. The Soluble Wnt Receptor Frizzled8CRD-hFc Inhibits the Growth of Teratocarcinomas In vivo. Cancer Res 2007 Jun 1; 67(11): 5371-9. View Abstract on PubMed

  • Chen Y, Clark S, Wong T, Chen Y, Chen Y, Dennis MS, Luis E, Zhong F, Bheddah S, Koeppen H, Gogineni A, Polakis P. Armed Antibodies Targeting the Mucin Repeats of the Ovarian Cancer Antigen, MUC16, Are Highly Efficacious in Animal Tumor Models. Cancer Res 2007 May 15; 67(10): 4924-32. View Abstract on PubMed

  • Polakis P. The many ways of Wnt in cancer. Curr Opin Genet Dev 2007 Feb; 17(1): 45-51. View Abstract on PubMed

  • Shulewitz M, Soloviev I, Wu T, Koeppen H, Polakis P, Sakanaka C. Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer. Oncogene 2006 Jul 20; 25(31): 4361-9. View Abstract on PubMed

  • Rubinfeld B, Upadhyay A, Clark SL, Fong SE, Smith V, Koeppen H, Ross S, Polakis P. Identification and immunotherapeutic targeting of antigens induced by chemotherapy. Nat Biotechnol 2006 Feb; 24(2): 205-9. View Abstract on PubMed

  • Polakis P. Arming antibodies for cancer therapy. Curr Opin Pharmacol 2005 Aug; 5(4): 382-7. View Abstract on PubMed

  • Mao W, Luis E, Ross S, Silva J, Tan C, Crowley C, Chui C, Franz G, Senter P, Koeppen H, Polakis P. EphB2 as a therapeutic antibody drug target for the treatment of colorectal cancer. Cancer Res 2004 Feb 1; 64(3): 781-8. View Abstract on PubMed

  • Rubinfeld B, Robbins P, El-Gamil M, Albert I, Porfiri E, Polakis P. Stabilization of beta-catenin by genetic defects in melanoma cell lines. Science 1997 Mar 21; 275(5307): 1790-2. View Abstract on PubMed

  • Rubinfeld B, Albert I, Porfiri E, Fiol C, Munemitsu S, Polakis P. Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 1996 May 17; 272(5264): 1023-6. View Abstract on PubMed

  • Munemitsu S, Albert I, Souza B, Rubinfeld B, Polakis P. Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc Natl Acad Sci U S A 1995 Mar 28; 92(7): 3046-50. View Abstract on PubMed

  • Rubinfeld B, Souza B, Albert I, Muller O, Chamberlain SH, Masiarz FR, Munemitsu S, Polakis P. Association of the APC gene product with beta-catenin. Science 1993 Dec 10; 262(5140): 1731-4. View Abstract on PubMed

  • Rubinfeld B, Munemitsu S, Clark R, Conroy L, Watt K, Crosier WJ, McCormick F, Polakis P. Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1. Cell 1991 Jun 14; 65(6): 1033-42. View Abstract on PubMed