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Peter Jackson

Peter Jackson
Peter Jackson Director, Staff Scientist: Research Oncology

Profile | Top Scientific Papers | Awards & Honors

Top Scientific Papers

  • Iwai H, Kim M, Yoshikawa Y, Ashida H, Ogawa M, Fujita Y, Muller D, Kirikae T, Jackson PK, Kotani S, Sasakawa. A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling. Cell 2007 Aug 24; 130(4): 611-23. View Abstract on PubMed

  • Keck JM, Summers MK, Tedesco D, Ekholm-Reed S, Chuang LC, Jackson PK, Reed SI. Cyclin E overexpression impairs progression through mitosis by inhibiting APC(Cdh1). J Cell Biol 2007 Jul 30; 178(3): 371-85. View Abstract on PubMed

  • Ban KH, Torres JZ, Miller JJ, Mikhailov A, Nachury MV, Tung JJ, Rieder CL, Jackson PK. The END network couples spindle pole assembly to inhibition of the anaphase-promoting complex/cyclosome in early mitosis. Dev Cell 2007 Jul; 13(1): 29-42. View Abstract on PubMed

  • Nachury MV, Loktev AV, Zhang Q, Westlake CJ, Peränen J, Merdes A, Slusarski DC, Scheller RH, Bazan JF, Sheffield VC, Jackson PK. A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell 2007 Jun 15; 129(6): 1201-13. View Abstract on PubMed

  • Lehman NL, Tibshirani R, Hsu JY, Natkunam Y, Harris BT, West RB, Masek MA, Montgomery K, van de Rijn M, Jackson PK. Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors. Am J Pathol. 2007 May; 170(5): 1793-805. View Abstract on PubMed

  • Verschuren EW, Jackson PK. Putting transcription repression and protein destruction in pRb's pocket. Dev Cell 2007 Feb; 12(2): 169-70. View Abstract on PubMed

  • Tung JJ, Padmanabhan K, Hansen DV, Richter JD, Jackson PK. Translational unmasking of Emi2 directs cytostatic factor arrest in meiosis II. Cell Cycle 2007 Mar 15; 6(6): 725-31. Epub 2007 Mar 1. View Abstract on PubMed

  • Westlake C, Junutula JR, Simon GC, Pilli M, Prekeris R, Scheller RH, Jackson PK, Eldridge AG. Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene. Proc Natl Acad Sci U SA 2007 Jan 23; 104(4): 1236-41. Epub 2007 Jan 17. View Abstract on PubMed

  • Marangos P, Verschuren EW, Chen R, Jackson PK, Carroll J. Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1). J Cell Biol 2007 Jan 1; 176(1): 65-75. Epub 2006 Dec 26. View Abstract on PubMed

  • Jackson PK. Developmental neurobiology: a destructive switch for neurons. Nature 2006 Jul 27; 442(7101): 365-6. View Abstract on PubMed

  • Miller JJ, Summers MK, Hansen DV, Nachury MV, Lehman NL, Loktev A, Jackson PK. Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor. Genes Dev 2006 Sep 1; 20(17): 2410-20. Epub 2006 Aug 18. View Abstract on PubMed

  • Huntzicker EG, Estay IS, Zhen H, Lokteva LA, Jackson PK, Oro AE. Dual degradation signals control Gli protein stability and tumor formation. Genes Dev 2006 Feb 1; 20(3): 276-81. Epub 2006 Jan 18. View Abstract on PubMed

  • Eldridge AG, Loktev AV, Hansen DV, Verschuren EW, Reimann JD, Jackson PK. The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1. Cell. 2006 Jan 27; 124(2): 367-80. View Abstract on PubMed

  • Hansen DV, Tung JJ, Jackson PK. CaMKII and polo-like kinase 1 sequentially phosphorylate the cytostatic factor Emi2/XErp1 to trigger its destruction and meiotic exit. Proc Natl Acad Sci U S A 2006 Jan 17; 103(3): 608-13. Epub 2006 Jan 9. View Abstract on PubMed

  • Pagano M, Jackson PK. Wagging the dogma; tissue-specific cell cycle control in the mouse embryo. Cell 2004 Sep 3; 118(5): 535-8. View Abstract on PubMed

  • Hansen DV, Loktev AV, Ban KH, Jackson PK. Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1. Mol Biol Cell 2004 Dec; 15(12): 5623-34. Epub 2004 Oct 6. View Abstract on PubMed

  • Guardavaccaro D, Kudo Y, Boulaire J, Barchi M, Busino L, Donzelli M, Margottin-Goguet F, Jackson PK, Yamasaki L, Pagano M. Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo. Dev Cell 2003 Jun; 4(6): 799-812. View Abstract on PubMed

  • Margottin-Goguet F, Hsu JY, Loktev A, Hsieh HM, Reimann JD, Jackson PK. Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase. Dev Cell 2003 Jun; 4(6): 813-26. View Abstract on PubMed

  • Jackson PK. Ubiquitinating a phosphorylated Cdk inhibitor on the blades of the Cdc4 beta-propeller. Cell. 2003 Jan 24; 112(2): 142-4. Comment on: Cell. 2003 Jan 24; 112(2): 243-56. View Abstract on PubMed

  • Jackson PK, Eldridge AG. The SCF ubiquitin ligase: an extended look. Mol Cell 2002 May; 9(5): 923-5. View Abstract on PubMed

  • Kaiser BK, Zimmerman ZA, Charbonneau H, Jackson PK. Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase. Mol Biol Cell 2002 Jul; 13(7): 2289-300. View Abstract on PubMed

  • Mailand N, Lukas C, Kaiser BK, Jackson PK, Bartek J, Lukas J. Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation. Nat Cell Biol 2002 Apr; 4(4): 317-22. View Abstract on PubMed

  • Hsu JY, Reimann JD, Sørensen CS, Lukas J, Jackson PK. E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1). Nat Cell Biol 2002 May; 4(5): 358-66. View Abstract on PubMed

  • Reimann JDR, Jackson PK. Emi1 is required for cytostatic factor arrest in vertebrate eggs. Nature 2002 Apr 25; 416(6883): 850-4. View Abstract on PubMed

  • Jackson PK. A new RING for SUMO: wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases. Genes Dev 2001 Dec 1; 15(23): 3053-8. View Abstract on PubMed

  • Reimann JDR, Gardner BE, Margottin-Goguet F, Jackson PK. Emi1 regulates the Anaphase-Promoting Complex by a different mechanism than Mad2 proteins. Genes Dev 2001 Dec 15; 15(24): 3278-85. View Abstract on PubMed

  • Furstenthall L, Swanson CS, Kaiser BK, Eldridge AE, Jackson PK. Triggering Cdk inhibitor destruction at origins of DNA replication. Nat Cell Biol 2001 Aug; 3(8): 715-22. View Abstract on PubMed

  • Reimann J, Freed E, Hsu J, Kramerm ER, Peters J, Jackson PK. Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex., Cdc20. Cell 2001 Jun 1; 105(5): 645-55. View Abstract on PubMed

  • Jackson PK, et al. Lore of the Rings. The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases. Trends Cell Biol 2000 Oct; 10(10): 429-39. View Abstract on PubMed

  • Furstenthall L, Kaiser BK, Swanson CS, Jackson PK. Cyclin E uses Cdc6 as a chromatin-associated receptor required for DNA replication. J Cell Biol 2001 Mar 19; 152(6): 1267-78. View Abstract on PubMed

  • Freed E, Lacey K, Huey P, Lyapina S, Deshaies R, Stearns T, Jackson PK. Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle. Genes Dev 1999 Sep 1; 13(17): 2242-57. View Abstract on PubMed

  • Lacey K, Jackson PK, Stearns T. Cyclin-dependent kinases direct centrosome duplication. Proc Natl Acad Sci U S A 1999 Mar 16; 96(6): 2817-22. View Abstract on PubMed

  • Chen J, Jackson PK, Kirschner MW, Dutta A. Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA. Nature 1995 Mar 23; 374(6520): 386-8. View Abstract on PubMed

  • Jackson PK, Chevalier S, Phillipe M, Kirschner MW. Early events in DNA replication require cyclin E and are blocked by p21CIP1. J Cell Biol 1995 Aug; 130(4): 755-69. View Abstract on PubMed

  • King RW, Jackson PK, Kirschner MW. Mitosis in transition. Cell 1994 Nov 18; 79(4): 563-71. View Abstract on PubMed

  • Van Etten RA, Jackson PK, Baltimore D,Sanders MC, Matsudaira PT, Janmey PA. The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity. J Cell Biol 1994 Feb; 124(3): 325-40. View Abstract on PubMed

  • Jackson PK, Baltimore D, Picard D. Hormone-conditional transformation by fusion proteins of c-Abl and its transforming variants. EMBO J 1993 Jul; 12(7): 2809-19. View Abstract on PubMed

  • Tybulewicz VL, Crawford CE, Jackson PK, Bronson RT, Mulligan RC. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 1991 Jun 28; 65(7): 1153-63. View Abstract on PubMed

  • Mayer BJ, Jackson PK, Baltimore D. The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity. Proc Natl Acad Sci U S A 1991 Jan 15; 88(2): 627-31. View Abstract on PubMed

  • Van Etten RA, Jackson PK, Baltimore D. The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization. Cell 1989 Aug 25; 58(4): 669-78. View Abstract on PubMed

  • Jackson PK, Baltimore D. N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl. EMBO J 1989 Feb; 8(2): 449-56. View Abstract on PubMed