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Tom O'Brien

Tom O'Brien
Tom O'Brien Senior Scientist: Cell Regulation

Profile | Education/Background | Top Scientific Papers | Awards & Honors

Top Scientific Papers

  • Elling RA, Tangonan BT, Penny DM, Smith JT, Vincent DE, Hansen SK, O'Brien T, Romanowski MJ. Mouse Aurora A: expression in Escherichia coli and purification. Protein Expr Purif 2007 Jul; 54(1): 139-46. View Abstract on PubMed

  • Fahr BT, O'Brien T, Pham P, Waal ND, Baskaran S, Raimundo BC, Lam JW, Sopko MM, Purkey HE, Romanowski MJ. Tethering identifies fragment that yields potent inhibitors of human caspase-1. Bioorg Med Chem Lett 2006 Feb; 16(3): 559-62. View Abstract on PubMed

  • O'Brien T, Fahr BT, Sopko MM, Lam JW, Waal ND, Raimundo BC, Purkey HE, Pham P, Romanowski MJ. Structural analysis of caspase-1 inhibitors derived from Tethering. Acta Crystallograph Sect F Struct Biol Cryst Commun 2005 May 1; 61(Pt 5): 451-8. View Abstract on PubMed

  • Erlanson DA, McDowell RS, O'Brien T. Fragment-based drug discovery. J Med Chem 2004 Jul 1; 47(14): 3463-82. View Abstract on PubMed

  • Romanowski MJ, Scheer JM, O'Brien T, McDowell RS. Crystal structures of a ligand-free and malonate-bound human caspase-1: implications for the mechanism of substrate binding. Structure 2004 Aug; 12(8): 1361-71. View Abstract on PubMed

  • Hardy JA, Lam J, Nguyen JT, O'Brien T, Wells JA. Discovery of an allosteric site in the caspases. Proc Natl Acad Sci U S A 2004 Aug 24; 101(34): 12461-6. View Abstract on PubMed

  • O'Brien T, Lee D. Prospects for caspase inhibitors. Mini Rev Med Chem 2004 Feb; 4(2): 153-65. View Abstract on PubMed

  • Allen DA, Pham P, Choong IC, Fahr B, Burdett MT, Lew W, DeLano WL, Gordon EM, Lam JW, O'Brien T, Lee D. Identification of potent and novel small-molecule inhibitors of caspase-3. Bioorg Med Chem Lett 2003 Nov 3; 13(21): 3651-5. View Abstract on PubMed

  • Erlanson DA, Lam JW, Wiesmann C, Luong TN, Simmons RL, DeLano WL, Choong IC, Burdett MT, Flanagan WM, Lee D, Gordon EM, O'Brien T. In situ assembly of enzyme inhibitors using extended tethering. Nat Biotechnol 2003 Mar; 21(3): 308-14. View Abstract on PubMed

  • Choong IC, Lew W, Lee D, Pham P, Burdett MT, Lam JW, Wiesmann C, Luong TN, Fahr B, DeLano WL, McDowell RS, Allen DA, Erlanson DA, Gordon EM, O'Brien T. Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design. J Med Chem 2002 Nov 7; 45(23): 5005-22. View Abstract on PubMed

  • O'Brien T, Tjian R. Different functional domains of TAFII250 modulate expression of distinct subsets of mammalian genes. Proc Natl Acad Sci U S A 2000 Mar 14; 97(6): 2456-61. View Abstract on PubMed

  • O'Brien T, Tjian R. Functional analysis of the human TAFII250 N-terminal kinase domain. Mol Cell 1998 May; 1(6): 905-11. View Abstract on PubMed

  • Law A, Hirayoshi K, O'Brien T, Lis JT. Direct cloning of DNA that interacts in vivo with a specific protein: application to RNA polymerase II and sites of pausing in Drosophila. Nucleic Acids Res 1998 Feb 15; 26(4): 919-24. View Abstract on PubMed

  • Beckmann H, Chen JL, O'Brien T, Tjian R. Coactivator and promoter-selective properties of RNA polymerase I TAFs. Science 1995 Dec 1; 270(5241): 1506-9. View Abstract on PubMed

  • O'Brien T, Wilkins RC, Giardina C, Lis JT. Distribution of GAGA protein on Drosophila genes in vivo. Genes Dev 1995 May 1; 9(9): 1098-110. View Abstract on PubMed

  • O'Brien T, Hardin S, Greenleaf A, Lis JT. Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation. Nature 1994 Jul 7; 370(6484): 75-7. View Abstract on PubMed

  • O'Brien T, Lis JT. Rapid changes in Drosophila transcription after an instantaneous heat shock. Mol Cell Biol 1993 Jun; 13(6): 3456-63. View Abstract on PubMed

  • O'Brien T, Lis JT. RNA polymerase II pauses at the 5' end of the transcriptionally induced Drosophila hsp70 gene. Mol Cell Biol 1991 Oct; 11(10): 5285-90. View Abstract on PubMed

Books/Chapters

  • O'Brien T, Linton S, editors. Caspase inhibitors in drug discovery. Boca Raton: CRC Press; 2008.

  • Fernandes M, O'Brien T, Lis JT. Structure and regulation of heat shock gene promoters. In Morimoto R, Tissiers, A, Georgopoulos C, editors. The Biology of Heat Shock Proteins and Molecular Chaperones. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press; 1994. p. 375-93.