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Ira Mellman

Ira Mellman
Ira Mellman Vice President: Research Oncology

Profile | Education/Background | Top Scientific Papers | Awards & Honors

Top Scientific Papers

  • Di Pucchio T, Chatterjee B, Smed-Sorensen A, Clayton S, Palazzo A, Montes M, Xue Y, Mellman I, Banchereau J, Connolly JE. Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I. Nat Immunol 2008 May; 9(5): 551-7. View Abstract on PubMed

  • Reig N, Jiang A, Couture R, Sutterwala FS, Oqura Y, Flavell RA, Mellman I, Van der Goot FG. Maturation modulates caspase-1-independent responses of dendritic cells to Anthrax lethal toxin. Cell Microbiol 2008 May; 10(5): 1190-207. View Abstract on PubMed

  • Bloom O, Unternaehrer JJ, Jiang A, Shin JS, Delamarre L, Allen P, Mellman I. Spinophilin participates in information transfer at immunological synapses. J Cell Biol 2008 Apr 21; 181(2): 203-11. View Abstract on PubMed

  • Sfakianos J, Togawa A, Maday S, Hull M, Pypaert M, Cantley L, Toomre D, Mellman I. Par3 functions in the biogenesis of the primary cilium in polarized epithelial cells. J Cell Biol 2007 Dec 17; 179(6): 1133-40. View Abstract on PubMed

  • Jiang A, Bloom O, Ono S, Cui W, Unternaehrer J, Jiang S, Whitney JA, Connolly J, Banchereau J, Mellman I. Disruption of E-cadherin-medicated adhesion induces a functionally distinct pathway of dendritic cell maturation. Immunity 2007 Oct; 27(4): 610-24. View Abstract on PubMed

  • Lande R, Gregorio J, Facchinetti V, Chatterjee B, Wang YH, Homey B, Cao W, Wang YH, Su B, Nestle FO, Zal T, Mellman I, Schroder JM, Liu YJ, Gilliet M. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 2007 Oct 4; 449(7162): 564-9. View Abstract on PubMed

  • Mellman I. Private lives: reflections and challenges in understanding the cell biology of the immune system. Science 2007 Aug 3; 317(5838): 625-7. View Abstract on PubMed

  • Schuck S, Gerl MJ, Ang A, Manninen A, Keller P, Mellman I, Simons K. Rab10 is involved in basolateral transport in polarized Madin-Darby canine kidney cells. Traffic 2007 Jan; 8(1): 47-60. View Abstract on PubMed

  • Unternaehrer JJ, Chow A, Pypaert M, Inaba K, Mellman I. The tetraspanin CD9 mediates lateral association of MHC class II molecules on the dendritic cell surface. Proc Natl Acad Sci U S A 2007 Jan 2; 104(1): 234-9. View Abstract on PubMed

  • Shin JS, Ebersold M, Pypaert M, Delamarre L, Hartley A, Mellman I. Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination. Nature 2006 Nov 2; 444(7115): 115-8. View Abstract on PubMed

  • Mellman I. Endosomes come of age. In: Dikic I, editor. Endosomes. Georgetown: Landes Bioscience; 2006. P.

  • Touret N, Paroutis P, Terebiznik M, Harrison RE, Trombetta S, Pypaert M, Chow A, Jiang A, Shaw J, Yip C, Moore HP, van der Wel N, Houben D, Peters PJ, de Chastellier C, Mellman I, Grinstein S. Quantitative and dynamic assessment of the contribution of the ER to phagosome formation. Cell 2005 Oct 7; 123(1): 157-70. View Abstract on PubMed

  • Delamarre L, Couture R, Mellman I, Trombetta ES.Enhancing immunogenicity by limiting susceptibility to lysosomal proteolysis. J Exp Med 2006 Sep 4; 203(9): 2049-55. View Abstract on PubMed

  • Hua W, Sheff D, Toomre D, Mellman I. Vectorial insertion of apical and basolateral membrane proteins in polarized epithelial cells revealed by quantitative 3D live cell imaging. J Cell Biol 2006 Mar 27; 172(7): 1035-44. View Abstract on PubMed

  • Trombetta ES, Mellman I. Cell biology of antigen processing in vitro and in vivo. Annu Rev Immunol 2005; 23: 975-1028. View Abstract on PubMed

  • Anderson E, Maday S, Sfakianos J, Hull M, Winckler B, Sheff D, Fölsch H, Mellman I. Transcytosis of NgCAM in epithelial cells reflects differential signal recognition on the endocytic and secretory pathways. J Cell Biol 2005 Aug 15; 170(4): 595-605. View Abstract on PubMed

  • Delamarre L, Pack M, Chang H, Mellman I, Trombetta ES. Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate. Science 2005 Mar 11; 307(5715): 1630-4. View Abstract on PubMed

  • Ang AL, Taguchi T, Francis S, Fölsch H, Murrells LJ, Pypaert M, Warren G, Mellman I. Recycling endosomes can serve as intermediates during transport from the Golgi to the plasma membrane of MDCK cells. J Cell Biol 2004 Nov 8; 167(3): 531-43. View Abstract on PubMed

  • Steinman RM, Mellman I. Immunotherapy: bewitched, bothered, and bewildered no more. Science 2004 Jul 9; 305(5681): 197-200. View Abstract on PubMed

  • Fölsch H, Pypaert M, Maday S, Pelletier L, Mellman I. The AP-1A and AP-1B clathrin adaptor complexes define biochemically and functionally distinct membrane domains. J Cell Biol 2003 Oct 27; 163(2): 351-62 View Abstract on PubMed

  • Delamarre L, Holcombe H, Mellman I. Presentation of exogenous antigens on major histocompatibility complex (MHC) class I and MHC class II molecules is differentially regulated during dendritic cell maturation. J Exp Med 2003 Jul 7; 198(1): 111-22. View Abstract on PubMed

  • Trombetta ES, Ebersold M, Garrett W, Pypaert M, Mellman I. Activation of lysosomal function during dendritic cell maturation. Science 2003 Feb 28; 299(5611): 1400-3. View Abstract on PubMed

  • Koivisto UM, Hubbard AL, Mellman I. A novel cellular phenotype for familial hypercholesterolemia due to a defect in polarized targeting of LDL receptor. Cell 2001 Jun 1; 105(5): 575-85. View Abstract on PubMed

  • Fölsch H, Pypaert M, Schu P, Mellman I. Distribution and function of AP-1 clathrin adaptor complexes in polarized epithelial cells. J Cell Biol 2001 Feb 5; 152(3): 595-606. View Abstract on PubMed

  • Chow A, Toomre D, Garrett W, Mellman I. Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane. Nature 2002 Aug 29; 418(6901): 988-94. View Abstract on PubMed

  • Mellman I, Steinman RM. Dendritic cells: specialized and regulated antigen processing machines. Cell 2001 Aug 10; 106(3): 255-8. View Abstract on PubMed

  • Garrett WS, Chen LM, Kroschewski R, Ebersold M, Turley S, Trombetta S, Galán JE, Mellman I. Developmental control of endocytosis in dendritic cells by Cdc42. Cell 2000 Aug 4; 102(3): 325-34. View Abstract on PubMed

  • Turley SJ, Inaba K, Garrett WS, Ebersold M, Unternaehrer J, Steinman RM, Mellman I. Transport of peptide-MHC class II complexes in developing dendritic cells. Science 2000 Apr 21; 288(5465): 522-7. View Abstract on PubMed

  • Inaba K, Turley S, Iyoda T, Yamaide F, Shimoyama S, Reis e Sousa C, Germain RN, Mellman I, Steinman RM. The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli. J Exp Med 2000 Mar 20; 191(6): 927-36. View Abstract on PubMed

  • Mellman I, Warren G. The road taken: past and future foundations of membrane traffic. Cell 2000 Jan 7; 100(1): 99-112. View Abstract on PubMed

  • Fölsch H, Ohno H, Bonifacino JS, Mellman I. A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells. Cell 1999 Oct 15; 99(2): 189-98. View Abstract on PubMed

  • Kroschewski R, Hall A, Mellman I. Cdc42 controls secretory and endocytic transport to the basolateral plasma membrane of MDCK cells. Nat Cell Biol 1999 May; 1(1): 8-13. View Abstract on PubMed

  • Sheff DR, Daro EA, Hull M, Mellman I. The receptor recycling pathway contains two distinct populations of early endosomes with different sorting functions. J Cell Biol 1999 Apr 5; 145(1): 123-39. View Abstract on PubMed

  • Winckler B, Forscher P, Mellman I. A diffusion barrier maintains distribution of membrane proteins in polarized neurons. Nature 1999 Feb 25; 397(6721): 698-701. View Abstract on PubMed

  • Inaba K, Turley S, Yamaide F, Iyoda T, Mahnke K, Inaba M, Pack M, Subklewe M, Sauter B, Sheff D, Albert M, Bhardwaj N, Mellman I, Steinman RM. Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells. J Exp Med 1998 Dec 7; 188(11): 2163-73. View Abstract on PubMed

  • Pierre P, Mellman I. Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells. Cell 1998 Jun 26; 93(7): 1135-45. View Abstract on PubMed

  • Daro E, Sheff D, Gomez M, Kreis T, Mellman I. Inhibition of endosome function in CHO cells bearing a temperature-sensitive defect in the coatomer (COPI) component epsilon-COP. J Cell Biol 1997 Dec 29; 139(7): 1747-59. View Abstract on PubMed

  • Pierre P, Turley SJ, Gatti E, Hull M, Meltzer J, Mirza A, Inaba K, Steinman RM, Mellman I. Developmental regulation of MHC class II transport in mouse dendritic cells. Nature 1997 Aug 21; 388(6644): 787-92. View Abstract on PubMed

  • Brachet V, Raposo G, Amigorena S, Mellman I. Ii chain controls the transport of major histocompatibility complex class II molecules to and from lysosomes. J Cell Biol 1997 Apr 7; 137(1): 51-65. View Abstract on PubMed

  • Mellman I. Endocytosis and molecular sorting. Annu Rev Cell Dev Biol 1996; 12: 575-625. View Abstract on PubMed

  • Amigorena S, Drake JR, Webster P, Mellman I. Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes. Nature 1994 May 12; 369(6476): 113-20. View Abstract on PubMed

  • Matter K, Whitney JA, Yamamoto EM, Mellman I. Common signals control low density lipoprotein receptor sorting in endosomes and the Golgi complex of MDCK cells. Cell 1993 Sep 24; 74(6): 1053-64. View Abstract on PubMed

  • Matter K, Hunziker W, Mellman I. Basolateral sorting of LDL receptor in MDCK cells: the cytoplasmic domain contains two tyrosine-dependent targeting determinants. Cell 1992 Nov 27; 71(5): 741-53. View Abstract on PubMed

  • van der Sluijs P, Hull M, Webster P, Mâle P, Goud B, Mellman I. The small GTP-binding protein rab4 controls an early sorting event on the endocytic pathway. Cell 1992 Sep 4; 70(5): 729-40. View Abstract on PubMed

  • Amigorena S, Bonnerot C, Drake JR, Choquet D, Hunziker W, Guillet JG, Webster P, Sautes C, Mellman I, Fridman WH. Cytoplasmic domain heterogeneity and functions of IgG Fc receptors in B lymphocytes. Science 1992 Jun 26; 256(5065): 1808-12. View Abstract on PubMed

  • Hunziker W, Harter C, Matter K, Mellman I. Basolateral sorting in MDCK cells requires a distinct cytoplasmic domain determinant. Cell 1991 Sep 6; 66(5): 907-20. View Abstract on PubMed

  • Joiner KA, Fuhrman SA, Miettinen HM, Kasper LH, Mellman I. Toxoplasma gondii: fusion competence of parasitophorous vacuoles in Fc receptor-transfected fibroblasts. Science 1990 Aug 10; 249(4969): 641-6. View Abstract on PubMed

  • Kornfeld S, Mellman I. The biogenesis of lysosomes. Annu Rev Cell Biol 1989; 5: 483-525. View Abstract on PubMed

  • Miettinen HM, Rose JK, Mellman I. Fc receptor isoforms exhibit distinct abilities for coated pit localization as a result of cytoplasmic domain heterogeneity. Cell 1989 Jul 28; 58(2): 317-27. View Abstract on PubMed

  • Schmid SL, Fuchs R, Male P, Mellman I. Two distinct subpopulations of endosomes involved in membrane recycling and transport to lysosomes. Cell 1988 Jan 15; 52(1): 73-83. View Abstract on PubMed

  • Helenius A, I. Mellman, D. Wall D, Hubbard A. Endosomes. Trends in Biochem Sci 1983 78: 245-250.