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Ellen Filvaroff

Ellen Filvaroff
Ellen Filvaroff Senior Scientist: Molecular Oncology

Profile | Education/Background | Top Scientific Papers | Awards & Honors

Top Scientific Papers

  • Caunt M, Mak J, Liang WC, Stawicki S, Pan Q, Tong RK, Kowalski J, Ho C, Reslan HB, Ross J, Berry L, Kasman I, Zlot C, Cheng Z, Le Couter J, Filvaroff EH, Plowman G, Peale F, French D, Carano R, Koch AW, Wu Y, Watts RJ, Tessier-Lavigne M, Bagri A. Blocking neuropilin-2 function inhibits tumor cell metastasis. Cancer Cell 2008 Apr; 13(4): 331-42. View Abstract on PubMed

  • Schmidt M, De Mazière A, Smyczek T, Gray A, Parker L, Filvaroff E, French D, van Dijk S, Klumperman J, Ye W. The role of Egfl7 in vascular morphogenesis. Novartis Found Symp 2007; 283: 18-28; discussion 28-36, 238-41. View Abstract on PubMed

  • Balooch G, Balooch M, Nalla RK, Schilling S, Filvaroff EH, Marshall GW, Marshall SJ, Ritchie RO, Derynck R, Alliston T. TGF-beta regulates the mechanical properties and composition of bone matrix. Proc Natl Acad Sci U S A 2005 Dec 27; 102(52): 18813-8. View Abstract on PubMed

  • Maecker H, Varfolomeev E, Kischkel F, Lawrence D, LeBlanc H, Lee W, Hurst S, Danilenko D, Li J, Filvaroff E, Yang B, Daniel D, Ashkenazi A. TWEAK attenuates the transition from innate to adaptive immunity. Cell 2005 Dec 2; 123(5): 931-44. View Abstract on PubMed

  • Merchant M, Evangelista M, Luoh SM, Frantz GD, Chalasani S, Carano RA, van Hoy M, Ramirez J, Ogasawara AK, McFarland LM, Filvaroff EH, French DM, de Sauvage FJ. Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus. Mol Cell Biol 2005 Aug; 25(16): 7054-68. View Abstract on PubMed

  • Fang TD, Salim A, Xia W, Nacamuli RP, Guccione S, Song HM, Carano RA, Filvaroff EH, Bednarski MD, Giaccia AJ, Longaker MT. Angiogenesis is required for successful bone induction during distraction osteogenesis. J Bone Miner Res 2005 Jul; 20(7): 1114-24. View Abstract on PubMed

  • Carano R, Li Y, Bao M, Li J, Berry L, Ross J, Kowalski J, French D, Dugger D, Schwall R, Wang Y, Fei D, Moseley SL, Filvaroff EH. Effect of anti-TGF-beta antibodies in syngeneic mouse models of metastasis. J Musculoskelet Neuronal Interact 2004 Dec; 4(4): 377-8. View Abstract on PubMed

  • French DM, Kaul RJ, D'Souza AL, Crowley CW, Bao M, Frantz GD, Filvaroff EH, Desnoyers L. WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair. Am J Pathol 2004 Sep; 165 (3): 855-67. View Abstract on PubMed

  • Fang TD, Nacamuli RP, Song HM, Fong KD, Warren SM, Salim A, Carano RA, Filvaroff EH, Longaker MT. Creation and characterization of a mouse model of mandibular distraction osteogenesis. Bone 2004 Jun; 34 (6): 1004-12. View Abstract on PubMed

  • Stephan JP, Mao W, Filvaroff E, Cai L, Rabkin R, Pan G. Albumin stimulates the accumulation of extracellular matrix in renal tubular epithelial cells. Am J Nephrol 2004 Jan-Feb; 24(1): 14-9. View Abstract on PubMed

  • * Filvaroff EH. VEGF and bone. Journal of Musculoskeletal and Neuronal Interactions 2003 Dec; 3(4): 304-307.

  • ** Carano RA, Filvaroff EH. Angiogenesis and bone repair. Drug Discov Today 2003 Nov 1; 8(21): 980-9. View Abstract on PubMed

  • Filvaroff EH, Guillet S, Zlot C, Bao M, Ingle G, Steinmetz H, Hoeffel J, Bunting S, Ross J, Carano RA, Powell-Braxton L, Wagner GF, Eckert R, Gerritsen ME, French DM. Stanniocalcin 1 alters muscle and bone structure and function in transgenic mice. Endocrinology 2002 Sep; 143(9): 3681-90. View Abstract on PubMed

  • Cai L, Okumu FW, Cleland JL, Beresini M, Hogue D, Lin Z, Filvaroff EH. A slow release formulation of insulin as a treatment for osteoarthritis. Osteoarthritis Cartilage 2002 Sep; 10(9): 692-706. View Abstract on PubMed

  • Cai L, Suboc P, Hogue DA, Fei DT, Filvaroff EH. Interleukin 17 induced nitric oxide suppresses matrix synthesis and protects cartilage from matrix breakdown. J Rheumatol 2002 Aug; 29(8): 1725-36. View Abstract on PubMed

  • Street J, Bao M, DeGuzman L, Bunting S, Peale FV Jr, Ferrara N, Steinmetz H, Hoeffel J, Cleland JL, Daugherty A, Van Bruggen N, Redmond HP, Carano RA, Filvaroff EH. Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc Natl Acad Sci U S A 2002 Jul 23; 99(15): 9656-9661. View Abstract on PubMed

  • Cai L, Yin JP, Starovasnik MA, Hogue DA, Hillan KJ, Mort JS, Filvaroff EH. Pathways by which interleukin 17 induces articular cartilage breakdown in vitro and in vivo. Cytokine 2001 Oct 7; 16(1): 10-21. View Abstract on PubMed

  • Hymowitz SG, Filvaroff EH, Yin JP, Lee J, Cai L, Risser P, Maruoka M, Mao W, Foster J, Kelley RF, Pan G, Gurney AL, de Vos AM, Starovasnik MA. IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. EMBO J 2001 Oct 1; 20(19): 5332-41. View Abstract on PubMed

  • DenBesten PK, Machule D, Gallagher R, Marshall GW, Mathews C, Filvaroff E. The effect of TGF-b2 on dentin apposition rate and hardness in transgenic mice. Adv Dent Res 2001; 15:39-41. View Abstract on PubMed

  • Dubaquie Y, Mortensen DL, Intintoli A, Hogue DA, Nakamura G, Rancatore P, Lester P, Sadick MD, Filvaroff E, Fielder PJ, Lowman HB. Binding protein-3-selective insulin-like growth factor I variants: engineering, biodistributions, and clearance. Endocrinology 2001 Jan; 142(1): 165-73. View Abstract on PubMed

  • Filvaroff E, Erlebacher A, Ye J, Gitelman SE, Lotz J, Heillman M, Derynck R. Inhibition of TGF-beta receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass. Development 1999 Oct; 126(19): 4267-79. View Abstract on PubMed

  • Filvaroff E, Derynck R. Bone remodelling: a signalling system for osteoclast regulation. Curr Biol 1998 Sep 24; 8(19): R679-82. View Abstract on PubMed

  • Filvaroff EH, Derynck R. Induction of myogenesis in mesenchymal cells by MyoD depends on their degree of differentiation. Dev Biol 1996 Sep 15; 178(2): 459-71. View Abstract on PubMed

  • Erlebacher A, Filvaroff EH, Gitelman SE, Derynck R. Toward a molecular understanding of skeletal development. Cell 1995 Feb 10; 80(3): 371-8. View Abstract on PubMed

  • Filvaroff E, Calautti E, Reiss M, Dotto GP. Functional evidence for an extracellular calcium receptor mechanism triggering tyrosine kinase activation associated with mouse keratinocyte differentiation. J Biol Chem 1994 Aug 26; 269(34): 21735-40. View Abstract on PubMed

  • Filvaroff EH, Ebner R, Derynck R. Inhibition of myogenic differentiation in myoblasts expressing a truncated type II TGF-beta receptor. Development 1994 May; 120(5): 1085-95. View Abstract on PubMed

  • Filvaroff E, Calautti E, McCormick F, Dotto GP. Specific changes of Ras GTPase-activating protein (GAP) and a GAP-associated p62 protein during calcium-induced keratinocyte differentiation. Mol Cell Biol 1992 Dec; 12(12): 5319-28. View Abstract on PubMed

  • Missero C, Filvaroff E, Dotto GP. Induction of transforming growth factor beta 1 resistance by the E1A oncogene requires binding to a specific set of cellular proteins. Proc Natl Acad Sci U S A 1991 Apr 15; 88(8): 3489-93. View Abstract on PubMed

  • Filvaroff E, Stern DF, Dotto GP. Tyrosine phosphorylation is an early and specific event involved in primary keratinocyte differentiation. Mol Cell Biol 1990 Mar; 10(3): 1164-73. View Abstract on PubMed

* Invited review

** Invited review, cover