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Shiva Malek

Shiva Malek
Shiva Malek Senior Scientist: Biochemical Pharmacology

Profile | Education/Background | Top Scientific Papers | Awards & Honors

Top Scientific Papers

  • Hatzivassiliou G, Song K, Yen I, Brandhuber BJ, Anderson DJ, Alvarado R, Ludlam MJ, Stokoe D, Gloor SL, Vigers G, Morales T, Aliagas I, Liu B, Sideris S, Hoeflich KP, Jaiswal BS, Seshagiri S, Koeppen H, Belvin M, Friedman LS, Malek S. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature 2010 Feb 3. [Epub ahead of print] View Abstract on PubMed

  • Trinh L, Yen I, Lesnick J, Malek S. Development of Mechanistic Assays to Differentiate PI3K and mTor Inhibitors. EORTC 2009.

  • Yen I, Song K, Stokoe D, Liu B, Brandhuber B, Gloor S, Aliagas I, Anderson DJ, Voegtli W, Ludlum MJC, Alvarado R, Sideris S, Ramaswamy S, Heise C, Belvin M, Friedman L, Hatzivassiliou G, Malek S. Understanding the Effects of RAF Inhibitors on RAF Signaling in B-Raf V600E Mutant versus Wildtype Tumors. EORTC 2009.

  • Hatzivassiliou G, Sideris S, Yen I, Gloor S, Callejo M, Brandhuber B, Liu B, Belvin M, Malek S. Understanding the role of Raf signaling in B-RafV600E mutant and wildtype tumors. EORTC 2008.

  • Malek S, Straley K, Yuan R, Stack J, Pollock. Identification of small molecule modulators of pathological huntington protein structure. In preparation 2007.

  • Malek S, Huang DB, Huxford T, Ghosh S, Ghosh G. X-ray crystal structure of an IκBα x NF-κB p65 homodimer complex. J Biol Chem 2003 Jun 20; 278(25): 23094-100. View Abstract on PubMed

  • Malek S, Chen Y, Huxford T, Ghosh G. IκBα, but not IκBα, functions as a classical cytoplasmic inhibitor of NF-κB dimers by masking both NF-κB nuclear localization sequences in resting cells. J Biol Chem 2001 Nov 30; 276(48): 45225-35. View Abstract on PubMed

  • Huxford T, Malek S, Ghosh G. Preparation and crystallization of dynamic NF-κB:IκB complexes. J Biol Chem 2000 Oct 20; 275(42): 32800-6. View Abstract on PubMed

  • Phelps CB, Sengchanthalangsy LL, Malek S, Ghosh G. Mechanism of κB DNA binding by Rel/NF-κB dimers. J Biol Chem 2000 Aug 11; 275(32): 24392-9. View Abstract on PubMed

  • Huxford T, Malek S, Ghosh G. Structure and mechanism in NF-κB/IκB signaling. Cold Spring Harb Symp Quant Biol 1999; 64: 533-40. View Abstract on PubMed

  • Huxford T, Huang DB, Malek S, Ghosh G. The crystal structure of the IκBα/NF-κB complex reveals mechanisms of NF-κB inactivation. Cell 1998 Dec 11; 95(6): 759-70. View Abstract on PubMed

  • Malek S, Huxford T, Ghosh G. IκBα functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF-κB. J Biol Chem 1998 Sep 25; 273(39): 25427-35. View Abstract on PubMed

  • Wang E, Malek S, Feigon J. Structure of a G.T.A triplet in an intramolecular DNA triplex. Biochemistry 1992 May 26; 31(20): 4838-46. View Abstract on PubMed

  • Macaya RF, Gilbert DE, Malek S, Sinsheimer JS, Feigon J. Structure and stability of X.G.C mismatches in the third strand of intramolecular triplexes. Science 1991 Oct 11; 254(5029): 270-4. View Abstract on PubMed