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Shiva Malek
Scientist: Biochemical Pharmacology
Profile | Education/Background | Top Scientific Papers | Awards & Honors |
Top Scientific Papers
- Malek S, Straley K, Yuan R, Stack J, Pollock. Identification of small molecule modulators of pathological huntington protein structure. In preparation 2007.
- Malek S, Huang DB, Huxford T, Ghosh S, Ghosh G. X-ray crystal structure of an IκBα x NF-κB p65 homodimer complex. J Biol Chem 2003 Jun 20; 278(25): 23094-100. View Abstract on PubMed
- Malek S, Chen Y, Huxford T, Ghosh G. IκBα, but not IκBα, functions as a classical cytoplasmic inhibitor of NF-κB dimers by masking both NF-κB nuclear localization sequences in resting cells. J Biol Chem 2001 Nov 30; 276(48): 45225-35. View Abstract on PubMed
- Huxford T, Malek S, Ghosh G. Preparation and crystallization of dynamic NF-κB:IκB complexes. J Biol Chem 2000 Oct 20; 275(42): 32800-6. View Abstract on PubMed
- Phelps CB, Sengchanthalangsy LL, Malek S, Ghosh G. Mechanism of κB DNA binding by Rel/NF-κB dimers. J Biol Chem 2000 Aug 11; 275(32): 24392-9. View Abstract on PubMed
- Huxford T, Malek S, Ghosh G. Structure and mechanism in NF-κB/IκB signaling. Cold Spring Harb Symp Quant Biol 1999; 64: 533-40. View Abstract on PubMed
- Huxford T, Huang DB, Malek S, Ghosh G. The crystal structure of the IκBα/NF-κB complex reveals mechanisms of NF-κB inactivation. Cell 1998 Dec 11; 95(6): 759-70. View Abstract on PubMed
- Malek S, Huxford T, Ghosh G. IκBα functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF-κB. J Biol Chem 1998 Sep 25; 273(39): 25427-35. View Abstract on PubMed
- Wang E, Malek S, Feigon J. Structure of a G.T.A triplet in an intramolecular DNA triplex. Biochemistry 1992 May 26; 31(20): 4838-46. View Abstract on PubMed
- Macaya RF, Gilbert DE, Malek S, Sinsheimer JS, Feigon J. Structure and stability of X.G.C mismatches in the third strand of intramolecular triplexes. Science 1991 Oct 11; 254(5029): 270-4. View Abstract on PubMed