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Bruce Roth

Bruce Roth
Bruce Roth Vice President: Discovery Chemistry

Profile | Education/Background | Top Scientific Papers | Awards & Honors

Top Scientific Papers

  • Baumann KL, Butler DE, Deering CF, Mennen KE, Millar A, Nanninga TN, Palmer CW, Roth BD. The convergent synthesis of CI-981, an optically active, highly potent, tissue selective inhibitor of HMG-CoA reductase. Tetrahedron Lett 1992; 33: 2283-4.

  • Brower PL, Butler DE, Deering CF, Le TV, Millar A, Nanninga TN, Roth BD. The synthesis of (4R-Cis)-1, 1-dimethylethyl, 6-cyanomethyl-2,2-dimethyl-1,3- dioxane-4-acetate, a key intermediate for the preparation of CI-981, a highly potent, tissue selective inhibitor of HMG-CoA reductase. Tetrahedron Lett 1992; 33: 2279-82.

  • Roth BD, Blankley CJ, Chucholowski AW, Ferguson E, Hoefle ML, Ortwine DF, Newton RS, Sekerke CS, Sliskovic DR, Stratton CD, et al. Inhibitors of cholesterol biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran-2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus. J Med Chem 1991 Jan; 34(1): 357-66. View Abstract on PubMed

  • Roth BD, Bocan TM, Blankley CJ, Chucholowski AW, Creger PL, Creswell MW, Ferguson E, Newton RS, O'Brien P, Picard JA, et al. Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase. J Med Chem 1991 Jan; 34(1): 463-6. View Abstract on PubMed

  • Shaw MK, Newton RS, Sliskovic DR, Roth BD, Ferguson E, Krause BR. Hep-G2 cells and primary rat hepatocytes differ in their response to inhibitors of HMG-CoA reductase. Biochem Biophys Res Commun 1990 Jul 31; 170(2): 726-34. View Abstract on PubMed

  • Roth BD, Ortwine DF, Hoefle ML, Stratton CD, Sliskovic DR, Wilson MW, Newton RS. Inhibitors of cholesterol biosynthesis. 1. trans-6-(2-pyrrol-1-ylethyl)-4-hydroxypyran-2-ones, a novel series of HMG-CoA reductase inhibitors. 1. Effects of structural modifications at the 2- and 5-positions of the pyrrole nucleus. J Med Chem 1990 Jan; 33(1): 21-31. View Abstract on PubMed

  • Sliskovic DR, Roth BD, Wilson MW, Hoefle ML, Newton RS. Inhibitors of cholesterol biosynthesis. 2. 1,3,5-trisubstituted [2-(tetrahydro-4-hydroxy-2-oxopyran-6-yl)ethyl]pyrazoles. J Med Chem 1990 Jan; 33(1): 31-8. View Abstract on PubMed

  • Kende AS, Roth B, Sanfilippo PJ. Facile, palladium (II)- mediated synthesis of bridged and spirocyclic bicycloalkenones. J Am Chem Soc 1982; 104: 1784-5.

  • Kende AS, Roth B, Sanfilippo PJ, Blacklock TJ. Mechanism and regioisomeric control in palladium (II) - mediated cycloalkenylations. A novel total synthesis of (+/-)-quadrone. J Am Chem Soc 1982; 104: 5808-10.

  • Roth BD, Roark WH. Synthesis of a chiral synthon for the lactone portion of compactin and mevinolin. Tetrahedron Lett 1988; 29: 1255-8.