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Wendy Young

Wendy Young
Wendy Young Associate Director: Discovery Chemistry

Profile | Education/Background | Top Scientific Papers | Awards & Honors

Top Scientific Papers

  • Riggs JR, Hu H, Kolesnikov A, Leahy EM, Wesson KE, Shrader WD, Vijaykumar D, Wahl TA, Tong Z, Sprengeler PA, Green MJ, Yu C, Katz BA, Sanford E, Nguyen M, Cabuslay R, Young WB. Novel 5-azaindole factor VIIa inhibitors. Bioorg Med Chem Lett 2006 Jun 15; 16(12): 3197-200. View Abstract on PubMed

  • Vijaykumar D, Sprengeler PA, Shaghafi M, Spencer JR, Katz BA, Yu C, Rai R, Young WB, Schultz B, Janc J. Discovery of novel hydroxy pyrazole based factor IXa inhibitor. Bioorg Med Chem Lett 2006 May 15; 16(10): 2796-9. View Abstract on PubMed

  • Kolesnikov A, Rai R, Young WB, Mordenti J, Liu L, Torkelson S, Shrader WD, Leahy EM, Hu H, Gjerstad E, Janc J, Katz BA, Sprengeler PA. Factor VIIa inhibitors: improved pharmacokinetic parameters. Bioorg Med Chem Lett 2006 Apr 15; 16(8): 2243-6. View Abstract on PubMed

  • Rai R, Kolesnikov A, Sprengeler PA, Torkelson S, Ton T, Katz BA, Yu C, Hendrix J, Shrader WD, Stephens R, Cabuslay R, Sanford E, Young WB. Discovery of novel heterocyclic factor VIIa inhibitors. Bioorg Med Chem Lett 2006 Apr 15; 16(8): 2270-3. View Abstract on PubMed

  • Riggs JR, Kolesnikov A, Hendrix J, Young WB, Shrader WD, Vijaykumar D, Stephens R, Liu L, Pan L, Mordenti J, Green MJ, Sukbuntherng J. Factor VIIa inhibitors: a prodrug strategy to improve oral bioavailability. Bioorg Med Chem Lett 2006 Apr 15; 16(8): 2224-8. View Abstract on PubMed

  • Young WB, Mordenti J, Torkelson S, Shrader WD, Kolesnikov A, Rai R, Liu L, Hu H, Leahy EM, Green MJ, Sprengeler PA, Katz BA, Yu C, Janc JW, Elrod KC, Marzec UM, Hanson SR. Factor VIIa inhibitors: chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model. Bioorg Med Chem Lett 2006 Apr 1; 16(7): 2037-41. View Abstract on PubMed

  • Young WB, Rai R, Shrader WD, Burgess-Henry J, Hu H, Elrod KC, Sprengeler PA, Katz BA, Sukbuntherng J, Mordenti J. Small molecule inhibitors of plasma kallikrein. Bioorg Med Chem Lett 2006 Apr 1; 16(7): 2034-6. View Abstract on PubMed

  • Shrader WD, Kolesnikov A, Burgess-Henry J, Rai R, Hendrix J, Hu H, Torkelson S, Ton T, Young WB, Katz BA, Yu C, Tang J, Cabuslay R, Sanford E, Janc JW, Sprengeler PA. Factor VIIa inhibitors: gaining selectivity within the trypsin family. Bioorg Med Chem Lett 2006 Mar 15; 16(6): 1596-600. View Abstract on PubMed

  • Young WB, Sprengeler P, Shrader WD, Li Y, Rai R, Verner E, Jenkins T, Fatheree P, Kolesnikov A, Janc JW, Cregar L, Elrod K, Katz B. Generation of potent coagulation protease inhibitors utilizing zinc-mediated chelation. Bioorg Med Chem Lett 2006 Feb; 16(3): 710-3. View Abstract on PubMed

  • Tang J, Yu CL, Williams SR, Springman E, Jeffery D, Sprengeler PA, Estevez A, Sampang J, Shrader W, Spencer J, Young W, McGrath M, Katz BA. Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein. J Biol Chem 2005 Dec 9; 280(49): 41077-89. View Abstract on PubMed

  • Katz BA, Luong C, Ho JD, Somoza JR, Gjerstad E, Tang J, Williams SR, Verner E, Mackman RL, Young WB, Sprengeler PA, Chan H, Mortara K, Janc JW, McGrath ME. Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA). J Mol Biol 2004 Nov 19; 344(2): 527-47. View Abstract on PubMed

  • Schipper NG, Osterberg T, Wrange U, Westberg C, Sokolowski A, Rai R, Young W, Sjöström B. In vitro intestinal permeability of factor Xa inhibitors: influence of chemical structure on passive transport and susceptibility to efflux. Pharm Res 2001 Dec; 18(12): 1735-41. View Abstract on PubMed

  • Shrader WD, Young WB, Sprengeler PA, Sangalang JC, Elrod K, Carr G. Neutral inhibitors of the serine protease factor Xa. Bioorg Med Chem Lett 2001 Jul 23; 11(14): 1801-4. View Abstract on PubMed

  • Rai R, Kolesnikov A, Li Y, Young WB, Leahy E, Sprengeler PA, Verner E, Shrader WD, Burgess-Henry J, Sangalang JC, Allen D, Chen X, Katz BA, Luong C, Elrod K, Cregar L. Development of potent and selective factor Xa inhibitors. Bioorg Med Chem Lett 2001 Jul 23; 11(14): 1797-800. View Abstract on PubMed

  • Young WB, Kolesnikov A, Rai R, Sprengeler PA, Leahy EM, Shrader WD, Sangalang J, Burgess-Henry J, Spencer J, Elrod K, Cregar L. Optimization of a screening lead for factor VIIa/TF. Bioorg Med Chem Lett 2001 Sep 3; 11(17): 2253-6. View Abstract on PubMed

  • Verner E, Katz BA, Spencer JR, Allen D, Hataye J, Hruzewicz W, Hui HC, Kolesnikov A, Li Y, Luong C, Martelli A, Radika K, Rai R, She M, Shrader W, Sprengeler PA, Trapp S, Wang J, Young WB, Mackman RL. Development of serine protease inhibitors displaying a multicentered short (<2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasminogen activator and factor Xa. J Med Chem 2001 Aug 16; 44(17): 2753-71. View Abstract on PubMed

  • Katz BA, Elrod K, Luong C, Rice MJ, Mackman RL, Sprengeler PA, Spencer J, Hataye J, Janc J, Link J, Litvak J, Rai R, Rice K, Sideris S, Verner E, Young W. A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site. J Mol Biol 2001 Apr 13;307(5):1451-86. View Abstract on PubMed

  • Rai R, Sprengeler PA, Elrod KC, Young WB. Perspectives on factor Xa inhibition. Curr Med Chem 2001 Feb; 8(2): 101-19. View Abstract on PubMed

  • Rice KD, Wang VR, Gangloff AR, Kuo EY, Dener JM, Newcomb WS, Young WB, Putnam D, Cregar L, Wong M, Simpson PJ. Dibasic inhibitors of human mast cell tryptase. Part 2: structure-activity relationships and requirements for potent activity. Bioorg Med Chem Lett 2000 Oct 16; 10(20): 2361-6. View Abstract on PubMed

  • Danishefsky SJ, Masters JJ, Young WB, Link JT, Snyder LB, Magee TV, Jung DK, Isaacs RCA, Bornmann WG, Alaimo CA, Coburn CA, DiGrandi MJ. Total synthesis of baccatin III and taxol. J Am Chem Soc 1996 118(12): 2843-59.

  • Taylor EC, Young WB, Spanka C. Synthesis of N-{4-[2-(2-Amino-5,6-dihydro-4(3H)-oxo-7H-pyrrolo[2,3d]pyrimidin-6-yl)ethyl]benzoyl}-L-glutamic Acid: A ring contracted analogue of DDATHF. J Org Chem 1996 61(4): 1261-66.

  • Masters JJ, Jung DK, Danishefsky SJ, Snyder LB, Park TK, Young WB, Alaimo CA. A novel intramolecular heck reaction: synthesis of a cholesterol-baccatin III hybrid. Angew Chem Int Ed Eng 1995 34: 452.

  • Masters JJ, Link JT, Snyder LB, Young WB, Danishefsky SJ. A total synthesis of taxol. Angew Chem Int Ed Engl 1995 34(16): 1723-26.

  • Taylor EC, Young WB. Pyrrolo[3,2-d]pyrimidine folate analogues: "inverted" analogues of the cytotoxic agent LY231514. J Org Chem 1995 60: 7947.

  • Young WB, Link JT, Masters JJ, Snyder LB, Danishefsky S, De Gala S. Transformations of a baccatin III steroidal hybrid: unique reactivity patterns in oxidation and reduction reactions. Tetrahedron Lett 1995 Jul 10; 36(28): 4963-66.

  • Young WB, Masters JJ, Danishefsky SJ. Stereocontrolled syntheses of C-Aryl taxanes by intramolecular heck olefination - Novel instances of diastereofacial guidance by proximal coordination. J Am Chem Soc 1995 117(9): 5228-34.

  • Taylor EC, Young W, Chaudari R, Patel H. Syntheses of a regioisomer of N-{4-[2-(2-Amino-4(3H)-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl) ethyl]benzoyl}-L-glutamic Acid (LY231514), an active thymidylate synthetase inhibitor and antitumor agent. J Heterocycl Chem 1993 36: 1897.

  • Taylor EC, Young WB, Ward C. An expeditious synthesis of 2-Amino-4(3H)-oxo-5H-pyrrolo[3,2-d]pyrimidine (9-Deazaguanine). Tetrahedron Lett 1993 34: 4595-98.

  • Davies HML, Saikali E, Young WB. Synthesis of (±)-ferruginine and (±)- anhydroecgonine methyl ester by a tandem cyclopropanation/cope rearrangement. J Org Chem 1991 Sep 13; 56(19): 5696-700.

  • Davies HML, Young WB, Smith HD. A novel entry into the tropane alkaloids via reactions of vinylcarbenoids and pyrroles. Tetrahedron Lett. 1989 35: 4653.