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Helen Chan

Helen Chan
Helen Chan Associate Director: Drug Metabolism & Pharmacokinetics

Profile | Education/Background | Top Scientific Papers | Awards & Honors

Top Scientific Papers

  • Zhu Z, Chen HG, Goel OP, Chan OH, Stilgenbauer LA, Stewart BH. Phosphate prodrugs of PD154075. Bioorg Med Chem Lett 2000 May 15; 10(10): 1121-4. View Abstract on PubMed

  • Stewart BH, Chan OH. Use of immobilized artificial membrane chromatography for drug transport applications. J Pharm Sci 1998 Dec; 87(12): 1471-8. View Abstract on PubMed

  • Stewart BH, Chung FY, Tait B, Blankley CJ, Chan OH. Hydrophobicity of HIV protease inhibitors by immobilized artificial membrane chromatography: application and significance to drug transport. Pharm Res 1998 Sep; 15(9): 1401-6. View Abstract on PubMed

  • Chan OH, Schmid HL, Stilgenbauer LA, Howson W, Horwell DC, Stewart BH. Evaluation of a targeted prodrug strategy of enhance oral absorption of poorly water-soluble compounds. Pharm Res 1998 Jul; 15(7): 1012-8. View Abstract on PubMed

  • Chan OH, Sinz MW, Stewart BH. Multiple-model evaluation of absorption of tachykinin receptor antagonists. Adv Drug Del Rev 1997 23(1-3): 121-131.

  • Stewart BH, Chan OH, Jezyk N, Fleisher D. Discrimination between drug candidates using models for evaluation of intestinal absorption. Adv Drug Del Rev 1997 23(1-3): 27-45.

  • Chan OH, Stewart BH. Physicochemical and drug delivery considerations to oral drug bioavailability. Drug Dis. Today 1996 1(11): 461-473.

  • Chan OH, Schmid HL, Kuo BS, Wright DS, Howson W, Stewart BH. Absorption of Cam-2445, and NK1 neurokinin receptor antagonist: in vivo, in situ, and in vitro evaluations. J Pharm Sci 1996 Mar; 85(3): 253-7. View Abstract on PubMed

  • Hamilton HW, Steinbaugh BA, Stewart BH, Chan OH, Schmid HL, Schroeder R, Ryan MJ, Keiser J, Taylor MD, Blankley CJ, et al. Evaluation of physicochemical parameters important to the oral bioavailability of peptide-like compounds: implications for the synthesis of renin inhibitors. J Med Chem 1995 Apr 28; 38(9): 1446-55. View Abstract on PubMed

  • Stewart BH, Chan OH, Lu RH, Reyner EL, Schmid HL, Hamilton HW, Steinbaugh BA, Taylor MD. Comparison of intestinal permeabilities determined in multiple in vitro and in situ models: relationship to absorption in humans. Pharm Res 1995 May; 12(5): 693-9. View Abstract on PubMed

  • Hamilton H, Steinbaugh B, Blankley J, Taylor M, Chan OH, Stewart B, et al. Evaluation of the intestinal permeability and hepatic handling of peptidomimetic analogs. Bioorg Med Chem Lett 1993 3(5): 813-818.