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Cornelis Hop

Cornelis Hop
Cornelis Hop Director: Drug Metabolism & Pharmacokinetics

Profile | Education/Background | Top Scientific Papers | Awards & Honors

Top Scientific Papers

  • Hop CE. Use of nano-electrospray for metabolite identification and quantitative absorption, distribution, metabolism and excretion studies. Curr Drug Metab 2006 Jun; 7(5): 557-63. View Abstract on PubMed

  • Soglia JR, Contillo LG, Kalgutkar AS, Zhao S, Hop CE, Boyd JG, Cole MJ. A semiquantitative method for the determination of reactive metabolite conjugate levels in vitro utilizing liquid chromatography-tandem mass spectrometry and novel quaternary ammonium glutathione analogues. Chem Res Toxicol 2006 Mar; 19(3): 480-90. View Abstract on PubMed

  • Bao J, Hunt JA, Miao S, Rupprecht KM, Stelmach JE, Liu L, Ruzek RD, Sinclair PJ, Pivnichny JV, Hop CE, Kumar S, Zaller DM, Shoop WL, O'neill EA, O'keefe SJ, Thompson CM, Cubbon RM, Wang R, Zhang WX, Thompson JE, Doherty JB. p38 MAP kinase inhibitors: metabolically stabilized piperidine-substituted quinolinones and naphthyridinones. Bioorg Med Chem Lett 2006 Jan 1; 16(1): 64-8. View Abstract on PubMed

  • Yu LJ, Chen Y, Deninno MP, O'Connell TN, Hop CE. Identification of a novel glutathione adduct of diclofenac, 4'-hydroxy-2'-glutathione-deschloro-diclofenac, upon incubation with human liver microsomes. Drug Metab Dispos 2005 Apr; 33(4): 484-8. View Abstract on PubMed

  • Agrawal AK, Hop CE, Pang J, Silva Elipe MV, Desai RC, Leung KH, Franklin RB. In vitro metabolism of a new oxazolidinedione hypoglycemic agent utilizing liver microsomes and recombinant human cytochrome P450 enzymes. J Pharm Biomed Anal 2005 Feb 23; 37(2): 351-8. View Abstract on PubMed

  • Doran A, Obach RS, Smith BJ, Hosea NA, Becker S, Callegari E, Chen C, Chen X, Choo E, Cianfrogna J, Cox LM, Gibbs JP, Gibbs MA, Hatch H, Hop CE, Kasman IN, Laperle J, Liu J, Liu X, Logman M, Maclin D, Nedza FM, Nelson F, Olson E, Rahematpura S, Raunig D, Rogers S, Schmidt K, Spracklin DK, Szewc M, Troutman M, Tseng E, Tu M, Van Deusen JW, Venkatakrishnan K, Walens G, Wang EQ, Wong D, Yasgar AS, Zhang C. The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model. Drug Metab Dispos 2005 Jan; 33(1): 165-74. View Abstract on PubMed

  • Liu DQ, Karanam BV, Doss GA, Sidler RR, Vincent SH, Hop CE. In vitro metabolism of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl)-phenyl] methyl]benzamide], a peroxisome proliferator-activated receptor alpha/gamma agonist. II. Identification of metabolites by liquid chromatography-tandem mass spectrometry. Drug Metab Dispos 2004 Sep; 32(9): 1023-31. View Abstract on PubMed

  • Huskey SE, Dean BJ, Doss GA, Wang Z, Hop CE, Anari R, Finke PE, Robichaud AJ, Zhang M, Wang B, Strauss JR, Cunningham PK, Feeney WP, Franklin RB, Baillie TA, Chiu SH. The metabolic disposition of aprepitant, a substance P receptor antagonist, in rats and dogs. Drug Metab Dispos 2004 Feb; 32(2): 246-58. View Abstract on PubMed

  • Stelmach JE, Liu L, Patel SB, Pivnichny JV, Scapin G, Singh S, Hop CE, Wang Z, Strauss JR, Cameron PM, Nichols EA, O'Keefe SJ, O'Neill EA, Schmatz DM, Schwartz CD, Thompson CM, Zaller DM, Doherty JB. Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase. Bioorg Med Chem Lett 2003 Jan 20; 13(2): 277-80. View Abstract on PubMed

  • Hop CE, Bakhtiar R. Homocysteine thiolactone and protein homocysteinylation: mechanistic studies with model peptides and proteins. Rapid Commun Mass Spectrom 2002 16(11): 1049-53. View Abstract on PubMed

  • Hop CE, Wang Y, Kumar S, Elipe MV, Raab CE, Dean DC, Poon GK, Keohane CA, Strauss J, Chiu SH, Curtis N, Elliott J, Gerhard U, Locker K, Morrison D, Mortishire-Smith R, Thomas S, Watt AP, Evans DC. Identification of metabolites of a substance P (neurokinin 1 receptor) antagonist in rat hepatocytes and rat plasma. Drug Metab Dispos 2002 Aug; 30(8): 937-43. View Abstract on PubMed

Books

  • CECA Hop, Kalgutkar AS, Soglia JR. Importance of early assessment of bioactivation in drug discovery. In: Doherty AM, editor. Annual reports in medicinal chemistry. Vol. 41. Amsterdam: Elsevier; 2006. p. 369-81.

  • Hop CECA. LC-MS in drug disposition and metabolism. In: Caprioli RM, editor. Encyclopedia of mass spectrometry. Vol. 3, Pt. B. Amsterdam: Elsevier; 2006. p. 233-74.

  • Hop CECA, Prakash C. Metabolite identification by LC-MS: Applications in drug discovery and development. In: Chowdhury SK, editor. Identification and quantification of drugs, metabolites and metabolizing enzymes by LC-MS. Elsevier, Amsterdam: Elsevier; 2005. p. 123-58.